Chicago Cubs vs Cincinnati Reds Prediction & Picks - MLB

USA - MLB

Chicago Cubs
5/7/26 14:20
Cincinnati Reds

Prediction:

 

UNDER 8.5

−104
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Travis Pulver | in MLB Picks

The Chicago Cubs will try to close out their current homestand undefeated when they face the Cincinnati Reds in the final game of a four-game series Thursday afternoon at Wrigley Field in the Windy City. Fans can follow the action on MLB.TV once the game gets underway at 2:20 P.M. EST.

All three wins against the Reds have been by a single run (5-4, 3-2 F/10, and 7-6 F/10). While Wednesday’s win extended their current win streak to eight games, it was also the Cubs’ fourteenth consecutive win at home.

To help make it 15 in a row, they are scheduled to send Shota Imanaga to the mound to start the day. Imanaga is 3-2 in seven starts with a 2.40 ERA and a 0.85 WHIP. He went seven innings vs. Arizona in his last start (May 2), allowing just four hits and a walk while striking out five and holding them scoreless.

As for the Reds, with three losses to the Cubs, their losing streak has extended to six in a row. They are scheduled to give Rhett Lowder the ball to start the day on the mound. Lowder is 3-2 in five starts with a 5.09 ERA and a 1.39 WHIP. He did not do well in his last outing, giving up five hits, four walks, and eight runs to the Pirates on May 2 in just 1 1/3 innings before getting pulled.


 

Conviction of the Day

Our editorial team's top-confidence pick, every day.

Members only · free sign-up

Sign up for free

Chicago Cubs vs Cincinnati Reds Form

Table

Teams Pts P W L
7 Chicago Cubs
0.549 162 89 73
24 Cincinnati Reds
0.463 162 75 87

Chicago Cubs and Cincinnati Reds Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 6, 2026 - MLB

Chicago Cubs
7 :  6
Cincinnati Reds

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Chicago Cubs
8 :  4
Arizona Diamondbacks

May 2, 2026 - MLB

Chicago Cubs
2 :  0
Arizona Diamondbacks

May 1, 2026 - MLB

Chicago Cubs
6 :  5
Arizona Diamondbacks
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 6, 2026 - MLB

Chicago Cubs
7 :  6
Cincinnati Reds

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Chicago Cubs
8 :  4
Arizona Diamondbacks

May 2, 2026 - MLB

Chicago Cubs
2 :  0
Arizona Diamondbacks

May 1, 2026 - MLB

Chicago Cubs
6 :  5
Arizona Diamondbacks
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 29, 2026 - MLB

San Diego Padres
4 :  5
Chicago Cubs

Apr 28, 2026 - MLB

San Diego Padres
3 :  8
Chicago Cubs

Apr 27, 2026 - MLB

San Diego Padres
9 :  7
Chicago Cubs

Apr 26, 2026 - MLB

Los Angeles Dodgers
6 :  0
Chicago Cubs

Apr 25, 2026 - MLB

Los Angeles Dodgers
12 :  4
Chicago Cubs

Apr 24, 2026 - MLB

Los Angeles Dodgers
4 :  6
Chicago Cubs
Cincinnati Reds
Cincinnati Reds Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

May 6, 2026 - MLB

Chicago Cubs
7 :  6
Cincinnati Reds

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Pittsburgh Pirates
1 :  0
Cincinnati Reds

May 2, 2026 - MLB

Pittsburgh Pirates
17 :  7
Cincinnati Reds

May 1, 2026 - MLB

Pittsburgh Pirates
9 :  1
Cincinnati Reds
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 30, 2026 - MLB

Cincinnati Reds
6 :  4
Colorado Rockies

Apr 29, 2026 - MLB

Cincinnati Reds
2 :  13
Colorado Rockies

Apr 28, 2026 - MLB

Cincinnati Reds
7 :  2
Colorado Rockies

Apr 26, 2026 - MLB

Cincinnati Reds
3 :  8
Detroit Tigers

Apr 25, 2026 - MLB

Cincinnati Reds
9 :  2
Detroit Tigers

Apr 24, 2026 - MLB

Cincinnati Reds
9 :  8
Detroit Tigers
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

May 6, 2026 - MLB

Chicago Cubs
7 :  6
Cincinnati Reds

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Pittsburgh Pirates
1 :  0
Cincinnati Reds

May 2, 2026 - MLB

Pittsburgh Pirates
17 :  7
Cincinnati Reds

May 1, 2026 - MLB

Pittsburgh Pirates
9 :  1
Cincinnati Reds

Chicago Cubs against Cincinnati Reds : Head to Head (H2H)

Chicago Cubs

67 %

Cincinnati Reds

33 %

May 6, 2026 - MLB

Chicago Cubs
7 :  6
Cincinnati Reds

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

Mar 20, 2026 - MLB Spring Training

Chicago Cubs
6 :  8
Cincinnati Reds

Mar 2, 2026 - MLB Spring Training

Cincinnati Reds
17 :  9
Chicago Cubs

Aug 6, 2025 - MLB

Chicago Cubs
6 :  1
Cincinnati Reds
Chicago Cubs vs Cincinnati Reds Picks

Chicago Cubs - Cincinnati Reds Key Points

  1. Chicago leads the all-time series vs. the Reds, 1215-1194-22.
  2. The Cubs are 17-19 ATS (run line) this season; the Reds are 22-13.
  3. The OVER is 22-13-1 for Chicago and 21-14-1 for Cincinnati.
  4. Betting Public: 27% of total tickets and 39% of the handle are on the UNDER.

Our Chicago Cubs vs Cincinnati Reds Prediction

I can see why the public is going heavy on the OVER; Lowder gave up eight runs while recording just four outs in his last start. However, the Cubs have not been hitting so well to give fans reason to think they may do the same (.249 over the last week while averaging just over five runs per game). As bad as his last outing was, Lowder averaged two runs per game across his other six starts. As for the Reds, they’ve been hitting .215 and averaging 3+ runs per game. Imanaga may shut them out.

Chicago will win this game and probably cover the run line, too. But I’m taking the Under on this one.

Our Cincinnati vs. Chicago Pick: UNDER 8.5

Prediction:

 

UNDER 8.5

−104
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.