Chicago Cubs vs Cincinnati Reds Prediction & Picks - MLB

USA - MLB

Chicago Cubs
5/6/26 19:40
Cincinnati Reds

Prediction:

 

Chicago Cubs ML

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 by Matt Lowrimore | in MLB Picks

Another full 15-game MLB slate is scheduled for Wednesday, including an NL Central matchup between the Chicago Cubs and the Cincinnati Reds. Let’s take a look at the match statistics and predictions for this game between the Cubs and the Reds.

Given that the NL Central is one of the tightest divisions in baseball right now, Cincinnati is off to a solid start. They will look to continue this stretch in Game 3, where they are scheduled to start Brady Singer. 

Singer comes into this game with a record of 2-2 on the season, but has an ERA of 5.57. That said, he has been even worse on the road this season, suggesting his struggles could continue against an above-average Cubs’ offense.

As for Chicago, they are sitting in 1st place in the NL Central, albeit by a small margin. The Cubs will counter in Game 3 with Colin Rea, who has a record of 4-1 and an ERA of 4.41. Despite his below-average ERA, he has been solid at home, suggesting the Reds’ offense may not have an answer for him.

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Chicago Cubs vs Cincinnati Reds Form

Table

Teams Pts P W L
7 Chicago Cubs
0.542 83 45 38
20 Cincinnati Reds
0.481 81 39 42

Chicago Cubs and Cincinnati Reds Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Chicago Cubs
8 :  4
Arizona Diamondbacks

May 2, 2026 - MLB

Chicago Cubs
2 :  0
Arizona Diamondbacks

May 1, 2026 - MLB

Chicago Cubs
6 :  5
Arizona Diamondbacks

Apr 29, 2026 - MLB

San Diego Padres
4 :  5
Chicago Cubs
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Chicago Cubs
8 :  4
Arizona Diamondbacks

May 2, 2026 - MLB

Chicago Cubs
2 :  0
Arizona Diamondbacks

May 1, 2026 - MLB

Chicago Cubs
6 :  5
Arizona Diamondbacks

Apr 23, 2026 - MLB

Chicago Cubs
8 :  7
Philadelphia Phillies
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 29, 2026 - MLB

San Diego Padres
4 :  5
Chicago Cubs

Apr 28, 2026 - MLB

San Diego Padres
3 :  8
Chicago Cubs

Apr 27, 2026 - MLB

San Diego Padres
9 :  7
Chicago Cubs

Apr 26, 2026 - MLB

Los Angeles Dodgers
6 :  0
Chicago Cubs

Apr 25, 2026 - MLB

Los Angeles Dodgers
12 :  4
Chicago Cubs

Apr 24, 2026 - MLB

Los Angeles Dodgers
4 :  6
Chicago Cubs
Cincinnati Reds
Cincinnati Reds Latest matches
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Pittsburgh Pirates
1 :  0
Cincinnati Reds

May 2, 2026 - MLB

Pittsburgh Pirates
17 :  7
Cincinnati Reds

May 1, 2026 - MLB

Pittsburgh Pirates
9 :  1
Cincinnati Reds

Apr 30, 2026 - MLB

Cincinnati Reds
6 :  4
Colorado Rockies
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 30, 2026 - MLB

Cincinnati Reds
6 :  4
Colorado Rockies

Apr 29, 2026 - MLB

Cincinnati Reds
2 :  13
Colorado Rockies

Apr 28, 2026 - MLB

Cincinnati Reds
7 :  2
Colorado Rockies

Apr 26, 2026 - MLB

Cincinnati Reds
3 :  8
Detroit Tigers

Apr 25, 2026 - MLB

Cincinnati Reds
9 :  2
Detroit Tigers

Apr 24, 2026 - MLB

Cincinnati Reds
9 :  8
Detroit Tigers
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Pittsburgh Pirates
1 :  0
Cincinnati Reds

May 2, 2026 - MLB

Pittsburgh Pirates
17 :  7
Cincinnati Reds

May 1, 2026 - MLB

Pittsburgh Pirates
9 :  1
Cincinnati Reds

Apr 22, 2026 - MLB

Tampa Bay Rays
6 :  1
Cincinnati Reds

Chicago Cubs against Cincinnati Reds : Head to Head (H2H)

Chicago Cubs

33 %

Cincinnati Reds

67 %

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

Mar 20, 2026 - MLB Spring Training

Chicago Cubs
6 :  8
Cincinnati Reds

Mar 2, 2026 - MLB Spring Training

Cincinnati Reds
17 :  9
Chicago Cubs

Sep 21, 2025 - MLB

Cincinnati Reds
1 :  0
Chicago Cubs

Sep 20, 2025 - MLB

Cincinnati Reds
6 :  3
Chicago Cubs

Chicago Cubs - Cincinnati Reds Key Points

  1. Brady Singer has an ERA of 5.57 this season
  2. Brady Singer has an ERA of 7.41 on the road this season
  3. Colin Rea has an ERA of 4.41 this season
  4. Colin Rea has an ERA of 3.00 at home this season
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Our Chicago Cubs vs Cincinnati Reds Prediction

The Cubs are heavily favored in this game; however, they still look to be the best betting option. Going back to Singer, he has made 4 away starts this season, having allowed 15 runs (14 earned) over 17.0 innings. 

Rea, on the other hand, has made three appearances at home (two starts) and has allowed five earned runs over 15.0 innings. On top of that, Chicago’s offense ranks third in the league, while Cincinnati’s offense ranks 24th.

Therefore, because of the clear struggles Singer has shown on the road and especially going up against a top-ranked Cubs’ offense, our Chicago Cubs vs Cincinnati Reds prediction is: Chicago Cubs ML.

Prediction:

 

Chicago Cubs ML

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Chicago Cubs vs Cincinnati Reds Picks