St. Louis Cardinals vs Chicago White Sox Prediction & Picks - MLB
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by Stephen Abiola | in MLB Picks
St. Louis Cardinals (73-75) and Chicago White Sox (75-72) will clash for the second time in less than 24 hours at Busch Stadium on Saturday night. The Cardinals took the series opener 7-3 to end their three-game slide. It was a great night for rookies Bernal and Baez, each tallying three hits and two runs. However, it wasn’t an easy run for the Cards, who had to overcome a pair of homers by Chase Meidroth to defeat Chicago. They’re the -120 favorites to win again tonight.
Chicago White Sox, meanwhile, will need a big performance tonight to restore their command in the AL Central. The latest defeat was their seventh in the last 10 matches, trimming their division lead to 0.5 games over the Guardians. Their offense has been slow recently, scoring a combined total of eight runs in their last four assignments, which ended in losses. Things don’t look good for them at the moment.
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St. Louis Cardinals vs Chicago White Sox Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
12
|
0.519 | 162 | 84 | 78 |
|
19
|
0.475 | 162 | 77 | 85 |
St. Louis Cardinals and Chicago White Sox Latest Matches
2/6 (33%)
4/6 (67%)
Sep 9, 2026 - MLB
Sep 8, 2026 - MLB
Sep 7, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
2/6 (33%)
4/6 (67%)
Aug 30, 2026 - MLB
Aug 29, 2026 - MLB
Aug 28, 2026 - MLB
Aug 27, 2026 - MLB
Aug 26, 2026 - MLB
Aug 25, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 9, 2026 - MLB
Sep 8, 2026 - MLB
Sep 7, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 10, 2026 - MLB
Sep 9, 2026 - MLB
Sep 8, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 10, 2026 - MLB
Sep 9, 2026 - MLB
Sep 8, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 3, 2026 - MLB
Sep 2, 2026 - MLB
Sep 1, 2026 - MLB
Aug 31, 2026 - MLB
Aug 30, 2026 - MLB
Aug 29, 2026 - MLB
St. Louis Cardinals against Chicago White Sox : Head to Head (H2H)
67 %
33 %
Jun 19, 2025 - MLB
May 5, 2024 - MLB
May 3, 2024 - MLB
St. Louis Cardinals - Chicago White Sox Key Points
- The White Sox scored under 4.5 runs in eight of their last nine matches.
- The White Sox scored under 4.5 runs in six of their last seven away matches.
- The White Sox scored under 4.5 runs in three of their last four games against the Cardinals.
- The Cardinals won their last four matches against the White Sox.
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Our St. Louis Cardinals vs Chicago White Sox Prediction
Bookies are expecting a tight contest, listing the White Sox as the -110 underdogs. They’ll be under pressure to maintain their division lead and improve their 32-41 away record. But we’re afraid they could be staring at another defeat, following their uninspiring performances, especially on offense. Besides not scoring enough runs, they’ve failed at least to cover the +1.5 spread in their last four matches. Even worse, the White Sox will start Luis Castillo, who is 4-11 this season with a 5.57 ERA. St. Louis will start the dependable Kyle Leahy, who is 10-4 this season with a 3.41 ERA. The starting pitchers give the Cardinals an edge.
Our prediction for St. Louis Cardinals vs Chicago White Sox: White Sox to score under 4.5 runs.
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