St. Louis Cardinals vs Chicago White Sox Prediction & Picks - MLB
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by Carlos Zabala | in MLB Picks
The White Sox, who scored only five runs and were shut out on Thursday, have been swept by the Pirates at PNC Park. They continue their road trip and will visit the Cardinals starting Friday. At the same time, the White Sox are feeling the pressure from the Guardians, who are only 1.5 games behind them in the division lead.
The Cardinals have suffered devastating blows to their wild-card aspirations in recent weeks; they currently have a 72-75 record. Winn is on day-to-day status, and Wetherholt is on the day-to-day injured list with a wrist injury. At this point, St. Louis' immediate goal may be to finish the season with a winning record. The weekend series will have emotional significance for them, as they will be commemorating the 2006 World Series champions.
The Cardinals were also swept on the road by the Giants. They fell 6-7 on Wednesday. It was a game they were winning 6-1 in the sixth inning and ended up losing.
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St. Louis Cardinals vs Chicago White Sox Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
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12
|
0.519 | 162 | 84 | 78 |
|
19
|
0.475 | 162 | 77 | 85 |
St. Louis Cardinals and Chicago White Sox Latest Matches
2/6 (33%)
4/6 (67%)
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2/6 (33%)
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2/6 (33%)
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2/6 (33%)
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2/6 (33%)
4/6 (67%)
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2/6 (33%)
4/6 (67%)
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St. Louis Cardinals against Chicago White Sox : Head to Head (H2H)
67 %
33 %
Jun 19, 2025 - MLB
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St. Louis Cardinals - Chicago White Sox Key Points
- The White Sox are averaging 4.7 runs per game this season
- The Cardinals have the third-fewest home run allowed in MLB
- The White Sox have a 32-40 road record this season
- The White Sox's collective slugging percentage is the tenth-best in MLB at .405
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Our St. Louis Cardinals vs Chicago White Sox Prediction
The first game of the series certainly presents a tremendous opportunity for both teams' offenses to rally, as it will pit two struggling pitchers against each other. Furthermore, in the betting odds, the White Sox's O/U record this season is 82-64.
Liberatore will start for the Cardinals with an 0-8 record and a 6.75 ERA in his last nine starts. But Kay, the Chicago starter, is also in the midst of a slump, with an 0-3 record and a 6.84 ERA in his last five appearances.
Our prediction for Cardinals vs White Sox is: Over 8 runs.
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