Seattle Mariners vs Chicago White Sox Prediction & Picks - MLB

USA - MLB

Seattle Mariners
5/20/26 16:10
Chicago White Sox

Prediction:

 

Under 7.5 Total Runs

-108
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 by Matt Lowrimore | in MLB Picks

A 15-game MLB slate is scheduled for Wednesday, which will include an AL matchup between the Seattle Mariners and the Chicago White Sox. Let’s take a look at the match statistics and predictions for this game between the Mariners and the White Sox.

While the White Sox are not one of the top teams in the league, they are easily one of the most improved. Looking at Game 3 of this series, the White Sox are scheduled to start Sean Burke. This season, Burke has posted a record of 2-3 and an ERA  of 4.10. Despite this, Burke has been excellent on the road, which could spell trouble for the Mariners in terms of being able to generate offense. 

As for Seattle, they have been floating under .500 for much of the season, but will look to improve on their record in Game 3 of this series by starting Emerson Hancock. He has a record of 3-2 this season and an ERA of 3.02. Hancock’s biggest strength this season has been pitching at home, further suggesting that this game could be a pitcher’s duel.

Seattle Mariners vs Chicago White Sox Form

Table

Teams Pts P W L
10 Chicago White Sox
0.521 117 61 56
24 Seattle Mariners
0.471 119 56 63

Seattle Mariners and Chicago White Sox Latest Matches

Seattle Mariners
Seattle Mariners Latest matches
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 18, 2026 - MLB

Seattle Mariners
6 :  1
Chicago White Sox

May 17, 2026 - MLB

Seattle Mariners
3 :  8
San Diego Padres

May 16, 2026 - MLB

Seattle Mariners
4 :  7
San Diego Padres

May 15, 2026 - MLB

Seattle Mariners
0 :  2
San Diego Padres

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 18, 2026 - MLB

Seattle Mariners
6 :  1
Chicago White Sox

May 17, 2026 - MLB

Seattle Mariners
3 :  8
San Diego Padres

May 16, 2026 - MLB

Seattle Mariners
4 :  7
San Diego Padres

May 15, 2026 - MLB

Seattle Mariners
0 :  2
San Diego Padres

May 6, 2026 - MLB

Seattle Mariners
3 :  1
Atlanta Braves

May 5, 2026 - MLB

Seattle Mariners
2 :  3
Atlanta Braves
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners

May 12, 2026 - MLB

Houston Astros
2 :  10
Seattle Mariners

May 11, 2026 - MLB

Houston Astros
1 :  3
Seattle Mariners

May 10, 2026 - MLB

Chicago White Sox
2 :  1
Seattle Mariners

May 9, 2026 - MLB

Chicago White Sox
6 :  1
Seattle Mariners
Chicago White Sox
Chicago White Sox Latest matches
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 18, 2026 - MLB

Seattle Mariners
6 :  1
Chicago White Sox

May 17, 2026 - MLB

Chicago White Sox
9 :  8
Chicago Cubs

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

May 15, 2026 - MLB

Chicago White Sox
5 :  10
Chicago Cubs

May 14, 2026 - MLB

Chicago White Sox
6 :  2
Kansas City Royals

May 13, 2026 - MLB

Chicago White Sox
6 :  5
Kansas City Royals
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 17, 2026 - MLB

Chicago White Sox
9 :  8
Chicago Cubs

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

May 15, 2026 - MLB

Chicago White Sox
5 :  10
Chicago Cubs

May 14, 2026 - MLB

Chicago White Sox
6 :  2
Kansas City Royals

May 13, 2026 - MLB

Chicago White Sox
6 :  5
Kansas City Royals

May 12, 2026 - MLB

Chicago White Sox
6 :  5
Kansas City Royals
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 18, 2026 - MLB

Seattle Mariners
6 :  1
Chicago White Sox

May 6, 2026 - MLB

Los Angeles Angels
8 :  2
Chicago White Sox

May 5, 2026 - MLB

Los Angeles Angels
4 :  3
Chicago White Sox

May 4, 2026 - MLB

Los Angeles Angels
0 :  6
Chicago White Sox

May 3, 2026 - MLB

San Diego Padres
4 :  3
Chicago White Sox

May 2, 2026 - MLB

San Diego Padres
0 :  4
Chicago White Sox

Seattle Mariners against Chicago White Sox : Head to Head (H2H)

Seattle Mariners

50 %

Chicago White Sox

50 %

May 18, 2026 - MLB

Seattle Mariners
6 :  1
Chicago White Sox

May 10, 2026 - MLB

Chicago White Sox
2 :  1
Seattle Mariners

May 9, 2026 - MLB

Chicago White Sox
6 :  1
Seattle Mariners

May 8, 2026 - MLB

Chicago White Sox
8 :  12
Seattle Mariners

Mar 22, 2026 - MLB Spring Training

Chicago White Sox
2 :  4
Seattle Mariners

Mar 7, 2026 - MLB Spring Training

Seattle Mariners
1 :  5
Chicago White Sox
Seattle Mariners vs Chicago White Sox Picks

Seattle Mariners - Chicago White Sox Key Points

  1. Sean Burke has an ERA of 4.10 this season
  2. Sean Burke has an ERA of 2.81 on the road this season
  3. Emerson Hancock has an ERA of 3.02 this season
  4. Emerson Hancock has an ERA of 2.48 at home this season

Our Seattle Mariners vs Chicago White Sox Prediction

Seattle is the clear favorite in this game; however, the under looks to be the best betting option. This simply has to do with how the starters have performed in terms of their home/away splits. Burke has made just three away starts this season, but has allowed just six runs (five earned) over 16.0 innings. 

Hancock, on the other hand, has made five home starts this season, having allowed just eight earned runs over 22.0 innings. Because of this and because both teams have a middle-of-the-pack offense, our Seattle Mariners vs Chicago White Sox prediction is: Under 7.5 Total Runs.

Prediction:

 

Under 7.5 Total Runs

-108
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.