Seattle Mariners vs Chicago White Sox Prediction & Picks - MLB

Prediction published on 5/18/26, 6:20 PM  by Carlos Zabala | Modified on 5/26/26 at 3:48 AM in MLB Picks

The weekend of rivalry has concluded, as has the Crosstown Classic, where the White Sox emerged stronger, having taken the series against their crosstown rivals, the Cubs. Riding that momentum, they head to T-Mobile Park to face a Mariners team in contrasting form, having been swept by the Padres and losing their sixth game of 2016 against San Diego.

On Sunday, the White Sox defeated the Cubs 9-8 in a packed stadium. It was a dramatic game that included a walk-off home run by Edgar Quero, an unlikely, cool player who nonetheless became the hero. This young White Sox team is hungry for success and has already improved its record to 24-22. Benintendi, Murakami, Vargas, and Montgomery are among the players who hit home runs in the series against the Cubs; it's been a long and productive stretch at the plate for them, proving that the resurgence of this team, which had a losing record in the previous two years, is no fluke.

Meanwhile, the Mariners continue to fall short of expectations, a stark contrast to the White Sox. Seattle reached the AL Championship Series in 2025 thanks to its starting pitching, but with the same rotation in 2026, it's performing at a more average level. Kirby was the latest to lose his grip on the game, allowing 6 ER in 5.2 IP against the Padres.