New York Yankees vs Chicago White Sox Prediction & Picks - MLB

Prediction published on 9/24/25, 3:09 PM  by Lou Aguila | Modified on 9/29/25 at 5:10 AM in MLB Picks

The New York Yankees aim to extend their winning streak to four games as they take on the Chicago White Sox in Game 2 of their series at Yankee Stadium.

The Yankees, who have received 72 percent of the bets, are heavy moneyline favorites at -375 and -166 on the -1.5 run line. The total is over/under 8.0 runs, which offers more intrigue since the total has gone OVER in three of the Yankees’ last 10 games.

Current Form:

The Yankees have won their last three games, including a close 3-2 win over the White Sox in the series opener. New York, 7-3 in their last 10 games, is within one game of the Toronto Blue Jays, who still hold the No.1 spot in the AL East with an 89-68 record.

New York has averaged 5.0 runs per game on a .251 BA over the last five games. During this stretch, the Yankees have posted an elite 1.20 ERA, and the bullpen finally made an impact with a 0.63 ERA over the last five games.

The White Sox have dropped their last three games and nine of their last 10. Chicago owns the worst record in the American League at 58-99 and the second-worst record in the MLB behind the 43-114 Colorado Rockies.

Chicago has pitched a solid 3.98 ERA in the last five games. However, they have only batted .188 at the plate, averaging 2.5 runs per game in this five-game spell.