Minnesota Twins vs Chicago White Sox Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Travis Pulver | in MLB Picks
The Minnesota Twins (64-70, 35-31 Home) are running out of time to make a move and get into the playoffs. Not only are they 6.5 back in the AL Central, but four games back for the last wild card spot. To that end, a win against their division rival, the Chicago White Sox (70-63, 29-36 Away) would certainly come in handy tonight.
Game time for this division rivalry is set for 8:10 p.m. EST at Target Field in Minneapolis, MN, with coverage provided by MLB.TV.
Dean Kremer is scheduled to start for the Twins today. Kremer is 2-4 on the season with a 5.22 ER but just a 1.18 WHIP. But since getting acquired by Minnesota, he has gone 1-0 in four starts with a 3.18 ERA. He faced the White Sox when he was still in Baltimore and pitched a solid game (six innings, four hits, one run allowed, and four strikeouts).
Chicago is expected to hand the ball to Luis Castillo. For the season, he is 4-10 with a 5.19 ERA and a 1.42 WHIP. Like Kremer, he was recently acquired by the White Sox. Since making the move, he has gone 1-1 in four starts with a 5.89 ERA.
Limited Offer. Currently at DraftKings
Our editorial team's top-confidence pick, every day.
Members only · free sign-up
Minnesota Twins vs Chicago White Sox Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
12
|
0.519 | 162 | 84 | 78 |
|
19
|
0.475 | 162 | 77 | 85 |
Minnesota Twins and Chicago White Sox Latest Matches
1/6 (17%)
5/6 (83%)
Aug 26, 2026 - MLB
Aug 25, 2026 - MLB
Aug 24, 2026 - MLB
Aug 23, 2026 - MLB
Aug 22, 2026 - MLB
Aug 21, 2026 - MLB
3/6 (50%)
3/6 (50%)
Aug 19, 2026 - MLB
Aug 18, 2026 - MLB
Aug 17, 2026 - MLB
Aug 16, 2026 - MLB
Aug 15, 2026 - MLB
Aug 13, 2026 - MLB
1/6 (17%)
5/6 (83%)
Aug 26, 2026 - MLB
Aug 25, 2026 - MLB
Aug 24, 2026 - MLB
Aug 23, 2026 - MLB
Aug 22, 2026 - MLB
Aug 21, 2026 - MLB
4/6 (67%)
2/6 (33%)
Aug 26, 2026 - MLB
Aug 25, 2026 - MLB
Aug 24, 2026 - MLB
Aug 23, 2026 - MLB
Aug 22, 2026 - MLB
Aug 21, 2026 - MLB
4/6 (67%)
2/6 (33%)
Aug 26, 2026 - MLB
Aug 25, 2026 - MLB
Aug 24, 2026 - MLB
Aug 23, 2026 - MLB
Aug 22, 2026 - MLB
Aug 21, 2026 - MLB
4/6 (67%)
2/6 (33%)
Aug 19, 2026 - MLB
Aug 18, 2026 - MLB
Aug 17, 2026 - MLB
Aug 16, 2026 - MLB
Aug 15, 2026 - MLB
Aug 14, 2026 - MLB
Minnesota Twins against Chicago White Sox : Head to Head (H2H)
50 %
50 %
Jun 3, 2026 - MLB
Jun 2, 2026 - MLB
Jun 1, 2026 - MLB
May 28, 2026 - MLB
May 27, 2026 - MLB
May 26, 2026 - MLB
Minnesota Twins - Chicago White Sox Key Points
- Minnesota and Chicago have met 33 times over the last three seasons; the Twins won 20 to the White Sox's 13.
- Minnesota is 34-31 ATS (run line) at home this season; Chicago is 37-28 ATS (run line) on the road.
- The OVER is 30-31-4 for the Twins at home and 37-27-1 for the White Sox on the road.
- Betting Public: 47% of moneyline tickets and 39% of the handle are on the Twins.
Limited Offer. Currently at DraftKings
Our Minnesota Twins vs Chicago White Sox Prediction
It is hard to have confidence in either pitcher, but I have much less in Castillo than I do Kremer. Kremer has been solid since joining the Twins and has a good history against White Sox hitters (.173, 9-52 with one home run and 11 Ks). Castillo was not great in Seattle, and a change of venue has not helped. He did have one brilliant outing against the Reds, but the other three were not good.
There is a good chance this ends up being a high-scoring game (OVER 9) because of unimpressive pitching and solid hitting. That also makes it hard to go with the run line. I see the Twins getting out to an early lead before Castillo gets pulled and holding on to win.
Our Chicago vs. Minnesota Pick: Twins ML
A Welcome Bonus for Minnesota Twins vs Chicago White Sox!

Looking to place a bet on Minnesota Twins vs Chicago White Sox? For this MLB match, DraftKings will treat you to an exclusive offer: $200 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.