Minnesota Twins vs Chicago White Sox Prediction & Picks - MLB

USA - MLB

Minnesota Twins
4/22/25 19:40
Chicago White Sox

Prediction:

 

Under 8.5

 

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 by Erik Gibbs in MLB Picks

The Chicago White Sox and Minnesota Twins kick off a three-game series on Tuesday in what's shaping up to be a basement battle in the AL Central. Neither team has found its footing early in the 2025 season, with the White Sox sitting at the very bottom of the division with a 5-17 record, while the Twins haven't fared much better at 7-14, just one spot ahead.

Chicago enters this series fresh off a 4-2 loss on the road to the Boston Red Sox on Monday, continuing what has been a rough stretch for a team that simply hasn't found consistency on either side of the ball. Meanwhile, the Twins are also licking their wounds after being swept by the Atlanta Braves over the weekend.

It was a disappointing outcome considering Atlanta has struggled themselves in the early going. In Sunday's finale, Minnesota briefly showed life with a seventh-inning homer from Byron Buxton, but ultimately fell short, losing 6-2.

Minnesota Twins vs Chicago White Sox Form

Table

Teams Pts P W L
27 Minnesota Twins
0.432 162 70 92
29 Chicago White Sox
0.37 162 60 102

Minnesota Twins and Chicago White Sox Latest Matches

Minnesota Twins
Minnesota Twins Latest matches
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 20, 2025 - MLB

Atlanta Braves
6 :  2
Minnesota Twins

Apr 19, 2025 - MLB

Atlanta Braves
4 :  3
Minnesota Twins

Apr 18, 2025 - MLB

Atlanta Braves
6 :  4
Minnesota Twins

Apr 16, 2025 - MLB

Minnesota Twins
4 :  3
New York Mets

Apr 15, 2025 - MLB

Minnesota Twins
6 :  3
New York Mets

Apr 14, 2025 - MLB

Minnesota Twins
1 :  5
New York Mets
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2025 - MLB

Minnesota Twins
4 :  3
New York Mets

Apr 15, 2025 - MLB

Minnesota Twins
6 :  3
New York Mets

Apr 14, 2025 - MLB

Minnesota Twins
1 :  5
New York Mets

Apr 13, 2025 - MLB

Minnesota Twins
5 :  1
Detroit Tigers

Apr 12, 2025 - MLB

Minnesota Twins
0 :  4
Detroit Tigers

Apr 11, 2025 - MLB

Minnesota Twins
6 :  7
Detroit Tigers
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 20, 2025 - MLB

Atlanta Braves
6 :  2
Minnesota Twins

Apr 19, 2025 - MLB

Atlanta Braves
4 :  3
Minnesota Twins

Apr 18, 2025 - MLB

Atlanta Braves
6 :  4
Minnesota Twins

Apr 10, 2025 - MLB

Kansas City Royals
3 :  2
Minnesota Twins

Apr 9, 2025 - MLB

Kansas City Royals
0 :  4
Minnesota Twins

Apr 8, 2025 - MLB

Kansas City Royals
2 :  1
Minnesota Twins
Chicago White Sox
Chicago White Sox Latest matches
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 21, 2025 - MLB

Boston Red Sox
4 :  2
Chicago White Sox

Apr 20, 2025 - MLB

Boston Red Sox
4 :  8
Chicago White Sox

Apr 19, 2025 - MLB

Boston Red Sox
4 :  3
Chicago White Sox

Apr 18, 2025 - MLB

Boston Red Sox
10 :  3
Chicago White Sox

Apr 17, 2025 - MLB

Chicago White Sox
0 :  8
Athletics

Apr 16, 2025 - MLB

Chicago White Sox
1 :  3
Athletics
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 17, 2025 - MLB

Chicago White Sox
0 :  8
Athletics

Apr 16, 2025 - MLB

Chicago White Sox
1 :  3
Athletics

Apr 15, 2025 - MLB

Chicago White Sox
3 :  12
Athletics

Apr 13, 2025 - MLB

Chicago White Sox
1 :  3
Boston Red Sox

Apr 12, 2025 - MLB

Chicago White Sox
3 :  2
Boston Red Sox

Apr 11, 2025 - MLB

Chicago White Sox
11 :  1
Boston Red Sox
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 21, 2025 - MLB

Boston Red Sox
4 :  2
Chicago White Sox

Apr 20, 2025 - MLB

Boston Red Sox
4 :  8
Chicago White Sox

Apr 19, 2025 - MLB

Boston Red Sox
4 :  3
Chicago White Sox

Apr 18, 2025 - MLB

Boston Red Sox
10 :  3
Chicago White Sox

Apr 10, 2025 - MLB

Cleveland Guardians
6 :  1
Chicago White Sox

Apr 9, 2025 - MLB

Cleveland Guardians
3 :  2
Chicago White Sox

Minnesota Twins against Chicago White Sox : Head to Head (H2H)

Minnesota Twins

83 %

Chicago White Sox

17 %

Apr 2, 2025 - MLB

Chicago White Sox
1 :  6
Minnesota Twins

Apr 1, 2025 - MLB

Chicago White Sox
3 :  8
Minnesota Twins

Mar 31, 2025 - MLB

Chicago White Sox
9 :  0
Minnesota Twins

Aug 4, 2024 - MLB

Minnesota Twins
13 :  7
Chicago White Sox

Aug 3, 2024 - MLB

Minnesota Twins
6 :  2
Chicago White Sox

Aug 2, 2024 - MLB

Minnesota Twins
10 :  2
Chicago White Sox

Minnesota Twins - Chicago White Sox Key Points

  1. The White Sox are 11-11 ATS this season
  2. The Twins are 9-13 ATS this season
  3. The White Sox are 8-0 covering the run line in last 8 Tuesday night games when road underdogs vs. AL Central teams
  4. The underdogs are 10-3 in the last 13 Twins games at Target Field

Our Minnesota Twins vs Chicago White Sox Prediction

Tuesday's series opener features a pitching matchup between two right-handers in Bailey Ober for Minnesota and Davis Martin for Chicago. Neither has lit the world on fire this season, but Martin has been marginally more reliable. Ober, 29, comes in with a 6.16 ERA over four starts, allowing five home runs and a total of 13 earned runs across those appearances. His control has been decent—17 strikeouts against six walks—but the long ball has been a persistent issue. He's coming off one of his better starts, however, having tossed 6.1 innings and giving up just three earned runs in a win over the Mets.

Davis Martin, on the other hand, has posted a 4.84 ERA through four outings, with 13 strikeouts and the same number of walks as Ober. While not dominant, he's been serviceable, and his numbers suggest slightly better command and damage control. In his most recent start, Martin went 5.1 innings and gave up four earned runs in a loss to the Oakland Athletics.

Though both teams have struggled, the matchup is closer than the records suggest. The Twins may have a slight edge on paper, but with Ober's inconsistency and tendency to give up home runs, the White Sox have a real chance to open this series with a competitive showing. Chicago might not be a powerhouse, but they're not massively outmatched either—and if Martin can keep things under control, the White Sox could steal one here. Our prediction for the Minnesota Twins vs. Chicago White Sox: White Sox to win.

Prediction:

 

Under 8.5

 

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Minnesota Twins vs Chicago White Sox Picks