Houston Astros vs Chicago White Sox Prediction & Picks - MLB
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by Lou Aguila | in MLB Picks
Posted at +147 to cover -1.5 runs, the Houston Astros will send Hunter Brown to help them force a Game 3 against the Chicago White Sox in their wild-card series.
The Astros are 3-0 in Brown’s last 3 starts against the White Sox and 5-0 in the pitcher’s last 5 mound appearances.
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The Houston Astros find themselves in a must-win in Game 2 of their wild-card series with the White Sox. The Astros’ bullpen game backfired as AJ Blubaugh surrendered 3 balls and Bryan King gave up 2 earned runs in the first inning, giving Chicago all the momentum to seize a 5-0 lead after five innings.
The Chicago White Sox are one win away from making it into the division series. The White Sox leaned on their batting corps to take charge, while pitcher Hagen Smith threw three scoreless innings to set the tone for the pitching staff.
Starting Pitchers: Astros RHP Hunter Brown (6-4, 3.19 ERA) vs. White Sox RHP Sean Burke (11-7, 3.34 ERA).
The Matchup: The Astros have won 7 of their 10 meetings with the White Sox.
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Houston Astros vs Chicago White Sox Form
Houston Astros and Chicago White Sox Latest Matches
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Houston Astros against Chicago White Sox : Head to Head (H2H)
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Houston Astros - Chicago White Sox Key Points
- Astros RHP Hunter Brown has posted a 2.73 ERA over his last five starts.
- White Sox RHP Sean Burke has posted a 4.64 ERA over his last five starts.
- The White Sox are averaging 6.5 runs over their last five games.
- The Rockies are averaging 7.4 runs over their last five games.
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Our Houston Astros vs Chicago White Sox Prediction
Key Stats: Hunter Brown has won his last three starts against the White Sox, two of which happened this year.
Brown threw seven scoreless innings in Houston’s 4-1 win over Chicago on July 25 and then surrendered two runs in a 6-2 win over the White Sox on September 3, 2026.
What to Expect: Brown dominates on the mound while the Astros’ offense puts on a much better effort to force a Game 3 of this series.
The Astros are 5-0 in Brown last 5 starts vs. the American League Central. Houston will need another stellar start from Brown to tame the White Sox’s batting corps. After scoring three runs in Game 1, the Astros should produce more runs in this game, especially if they can score off Sean Burke in the first few innings.
Fearless Forecast: Astros 5, White Sox 2
Our betting prediction for the Houston Astros vs. the Chicago White Sox: The Astros -1.5 Runs
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