Cleveland Guardians vs Chicago White Sox Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Lou Aguila | in MLB Picks
The Chicago White Sox and the Cleveland Guardians will kick off their division series on Saturday.
DraftKings has lowered the over/under to 7.0 runs despite these teams having averaged 10.2 combined runs per game over their last 7 meetings.
Current Form:
The Chicago White Sox finished off the Houston Astros in two games to arrange a division series against the Guardians. The White Sox stormed to an early lead in both games behind their electric offense powered by rookie slugger Munetaka Murakami and second baseman Chase Meidroth, who drove in three runs in Game 2. Chicago's pitching staff also delivered the goods in the wild card series, holding the Astros to 3 runs in both Games 1 and 2.
The Cleveland Guardians secured an outright postseason berth after capturing the AL Central title with an 85-77 record. The Guardians’ offensive numbers during the regular season (.239 with 678 runs) were mediocre at best, but their pitching metrics (3.77 ERA with a 1.26 WHIP) landed in the top-10.
Starting Pitchers: Guardians LHP Parker Messick (12-9, 2.56 ERA) vs. White Sox LHP Hagen Smith (3-3, 1.29 ERA).
The Matchup: The total has gone over in 7 of the last 10 meetings between the Guardians and the White Sox.
Limited Offer. Currently at DraftKings
Our editorial team's top-confidence pick, every day.
Members only · free sign-up
Cleveland Guardians vs Chicago White Sox Form
Cleveland Guardians and Chicago White Sox Latest Matches
4/6 (67%)
2/6 (33%)
Sep 27, 2026 - MLB
Sep 26, 2026 - MLB
Sep 25, 2026 - MLB
Sep 24, 2026 - MLB
Sep 23, 2026 - MLB
Sep 22, 2026 - MLB
5/6 (83%)
1/6 (17%)
Sep 20, 2026 - MLB
Sep 19, 2026 - MLB
Sep 18, 2026 - MLB
Sep 16, 2026 - MLB
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
4/6 (67%)
2/6 (33%)
Sep 27, 2026 - MLB
Sep 26, 2026 - MLB
Sep 25, 2026 - MLB
Sep 24, 2026 - MLB
Sep 23, 2026 - MLB
Sep 22, 2026 - MLB
5/6 (83%)
1/6 (17%)
Sep 30, 2026 - MLB
Sep 29, 2026 - MLB
Sep 27, 2026 - MLB
Sep 26, 2026 - MLB
Sep 25, 2026 - MLB
Sep 24, 2026 - MLB
4/6 (67%)
2/6 (33%)
Sep 27, 2026 - MLB
Sep 26, 2026 - MLB
Sep 25, 2026 - MLB
Sep 20, 2026 - MLB
Sep 19, 2026 - MLB
Sep 18, 2026 - MLB
4/6 (67%)
2/6 (33%)
Sep 30, 2026 - MLB
Sep 29, 2026 - MLB
Sep 24, 2026 - MLB
Sep 23, 2026 - MLB
Sep 22, 2026 - MLB
Sep 16, 2026 - MLB
Cleveland Guardians against Chicago White Sox : Head to Head (H2H)
50 %
50 %
Sep 16, 2026 - MLB
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
Aug 9, 2026 - MLB
Aug 8, 2026 - MLB
Aug 7, 2026 - MLB
Cleveland Guardians - Chicago White Sox Key Points
- Guardians LHP Parker Messick has posted a 3.20 ERA over his last 5 starts.
- White Sox LHP Hagen Smith has posted a 6.75 ERA over his last 5 starts.
- The totals have gone OVER in 3 of White Sox' last 5 games
- The totals have gone OVER in 42 of The Guardians' 81 last games at home
Limited Offer. Currently at DraftKings
Our Cleveland Guardians vs Chicago White Sox Prediction
Key Stats: The Guardians and the White Sox have averaged 10.2 combined runs per game over their last 7 meetings.
What to Expect: After averaging 6 runs per game in the wild card series against the Astros, the White Sox’s offense is in good shape to produce more runs in this best-of-five series against their division rivals. The core of Chicago’s batting lineup is healthy and prolific again after battling through injuries during their regular-season campaign.
As for the Guardians, they have scored at least 6 runs each in the last two meetings with the White Sox. Over their last five games, Cleveland has averaged 5.2 runs per game, which is buoyed by back-to-back games with 11 and 12 runs in the final series with the Royals.
Picking the winner is quite tricky for this particular game, but the White Sox seem to have the momentum after their splendid performance in the previous series.
Fearless Forecast: The White Sox 7, the Guardians 5
Our betting prediction for the Chicago White Sox vs. the Cleveland Guardians: Over 7.0 Runs
A Welcome Bonus for Cleveland Guardians vs Chicago White Sox!

Looking to place a bet on Cleveland Guardians vs Chicago White Sox? For this MLB match, DraftKings will treat you to an exclusive offer: $200 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.