Cleveland Guardians vs Chicago White Sox Prediction & Picks - MLB
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by Stephen Abiola in MLB Picks
Cleveland Guardians (77-75) and Chicago White Sox (77-74) will wrap up their three-game series on Wednesday evening at Progressive Field. The Guardians will seek to win this tiebreaker after recovering from an opening-day defeat to edge out the White Sox 7-6 on Tuesday night. Despite falling behind early, the Guardians fought back to take the lead in the sixth before securing the win. This win moves them just half a game behind the first-placed White Sox in the AL Central.
Chicago White Sox, meanwhile, will want to win and maintain their slim lead in the division. They’ve been out of form lately, going 3-7 in their last 10 matches. The White Sox will be boosted by the fact that their offense has clicked lately, racking up 20 runs in their last four assignments. However, their pitching must improve, having conceded 18 runs in their previous four matches. But generally, they’ve shown some improvement lately after a rough patch.
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Cleveland Guardians vs Chicago White Sox Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
11
|
0.51 | 151 | 77 | 74 |
|
12
|
0.507 | 152 | 77 | 75 |
Cleveland Guardians and Chicago White Sox Latest Matches
3/6 (50%)
3/6 (50%)
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
Sep 13, 2026 - MLB
Sep 12, 2026 - MLB
Sep 11, 2026 - MLB
Sep 9, 2026 - MLB
4/6 (67%)
2/6 (33%)
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
Sep 4, 2026 - MLB
3/6 (50%)
3/6 (50%)
Sep 13, 2026 - MLB
Sep 12, 2026 - MLB
Sep 11, 2026 - MLB
Sep 9, 2026 - MLB
Sep 8, 2026 - MLB
Sep 7, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
Sep 13, 2026 - MLB
Sep 12, 2026 - MLB
Sep 11, 2026 - MLB
Sep 10, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 10, 2026 - MLB
Sep 9, 2026 - MLB
Sep 8, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
Sep 13, 2026 - MLB
Sep 12, 2026 - MLB
Sep 11, 2026 - MLB
Sep 3, 2026 - MLB
Cleveland Guardians against Chicago White Sox : Head to Head (H2H)
33 %
67 %
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
Aug 9, 2026 - MLB
Aug 8, 2026 - MLB
Aug 7, 2026 - MLB
Jul 5, 2026 - MLB
Cleveland Guardians - Chicago White Sox Key Points
- The total runs went over in five of the last six Cleveland Guardians vs Chicago White Sox clashes.
- The total runs went over 7.5 in the last six Cleveland Guardians vs Chicago White Sox clashes.
- The total runs went over 7.5 in six of the last eight Cleveland Guardians matches.
- The total runs went over 7.5 in four of the last five Chicago White Sox matches.
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Our Cleveland Guardians vs Chicago White Sox Prediction
The Guardians are the -175 favorites due to their superior form and home advantage. They’ll start the reliable Parker Messick, who will want to improve his 11-9 record and 2.51 ERA. The left-hander has been excellent lately, posting a 2.10 ERA over his last five starts. But as mentioned earlier, the White Sox are scoring runs, so we expect them to tally at least three or four runs tonight. The risk, however, is Anthony Kay, who has a 9-9 record this season with a 4.53 ERA. He has had his lowest ERA this season, tallying a 7.23 ERA over his last five assignments. Overall, we’re backing Cleveland to win with the total runs going over 7.5.
Our prediction for Cleveland Guardians vs Chicago White Sox: Over 7.5 runs to hit.
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