Cleveland Guardians vs Chicago White Sox Prediction & Picks - MLB

Prediction published on 9/14/26, 6:16 AM  by Travis Pulver | Modified on 9/14/26 at 6:19 AM in MLB Picks

The Cleveland Guardians (76-74, 36-39 Home) are scheduled to host their division rivals, the Chicago White Sox (76-73, 33-42 Away), in a three-game series this week. Game One is today at Progressive Field in Cleveland, OH, at 6:40 p.m. EST (on ESPN Unlimited).

While the AL Central crown cannot be locked down in this series, the outcome of it will decide who has the upper hand down the stretch. The White Sox currently hold a .5 game lead over the Guardians and lead the season series between the two teams, 6-4.

Gavin Williams is scheduled to start the day on the mound for Cleveland. Williams has gone 13-7 in 29 starts with a 3.78 ERA and a 1.09 WHIP. Teams have hit .213 against him this season. When pitching at home, he has gone 7-3 with a 3.01 ERA and a .205 BA. This will be his fourth start against the White Sox this season; he has yet to factor into a decision against them.

Chicago appears to be going with a bullpen day and has reliever Sean Newcomb scheduled to open. Newcomb is 2-4 with four saves in 54 appearances (five starts) with a 2.77 ERA, a 1.14 WHIP, and teams have hit .216 against him. The White Sox have one of the better bullpens in baseball this season with a 3.69 ERA.