Cincinnati Reds vs Chicago White Sox Prediction & Picks - MLB

Prediction published on 5/15/25, 9:20 AM  by Carlos Zabala | Modified on 5/15/25 at 5:00 PM in MLB Picks

The good news that Pete Rose could be inducted into the Hall of Fame isn't entirely pleasing to Reds fans. Meanwhile, their team lost the first two games of the series against the White Sox, having started as -200 favorites or lower in the first two. A sweep at home on Thursday by the weak White Sox would mean this Reds team doesn't have the firepower to compete with the Cubs, Cardinals, and Brewers in the long run.

Lodolo allowed more hits than expected in Game 2, which ended 4-2 in favor of the White Sox, who scored all four runs before the Reds responded with their first in the bottom of the seventh inning via a home run by Steer. Elly de La Cruz went 1-for-4 in the loss, and his AVG now falls below .250. The Reds' Dominican star has only had a 3-hit game once this season, on March 31.

White Sox first baseman Andrew Vaughn is consistent with his bat, going exactly 1-for-4 in his last five games, the last of which was a home run against the Reds on Wednesday.

No team will be a bigger MLB betting favorite for Thursday than the Reds, with odds of -215 to beat the White Sox on Thursday.