Arizona Diamondbacks vs Chicago White Sox Prediction & Picks - MLB

Prediction published on 4/23/26, 12:07 PM  by Carlos Zabala | Modified on 4/23/26 at 6:50 PM in MLB Picks

Game 1 of the series between the White Sox and Diamondbacks in the desert brought home runs, but Game 2 resembled an absolute home run festival, with Arizona emerging victorious and avenging their Game 1 loss. Now, both Chicago and Arizona are looking to clinch the series, with Davis Marton taking on Michael Soroka for the Sox, who boasts a 4-0 record and 28 strikeouts in 22.2 innings pitched.

The White Sox are clearly making a significant impact. To say that slugger Murakami, with his perfectly timed swing, is on fire would be an understatement. He has hit towering home runs in five consecutive games, a tremendous streak that doesn't overshadow the excellent performance of his teammate Miguel Vargas. Vargas has homered in his last four games. However, their own pitching isn't as solid as their hitting, and it seems that this deficiency will be the White Sox's biggest weakness this season.

The thing is, the D-backs can hit too; this well-constructed lineup is designed to produce not only home runs, like Ildemaro Vargas's two with runners on base on Thursday, but extra-base hits and even triples are common in this lineup, which also boasts high-speed hitters. Perdomo hit his third triple of 2026 an inning before Arenado's fourth home run of the season.