Arizona Diamondbacks vs Chicago White Sox Prediction & Picks - MLB
USA - MLB
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by Carlos Zabala | in MLB Picks
The White Sox had a fantastic first day in the desert, winning the first game of the series against the Diamondbacks 11-5, with the highlight being Murakami-Vargas and Montgomery hitting back-to-back-to-back home runs. The Japanese slugger was expected to contribute his power, but he's exceeding expectations. This performance was his fourth consecutive game with a home run; he already has nine this season, but this doesn't necessarily mean the White Sox will win every game; in fact, they've started with a 9-14 record.
The Diamondbacks still have a winning record at 13-10, and Arizona's record at Chase Field is 7-4. It would not be surprising if they win the second game of the series, especially since the White Sox's record this season in Game 2s of series is 1-6.
The D-backs will start Venezuelan left-hander Eduardo Rodríguez, who has been performing exceptionally well since the beginning of the season, when he pitched Venezuela's final game against the USA in the WBC. Merryl Kelly faltered on Tuesday, but it seems unlikely the same will happen to Rodríguez, who has a 1.96 ERA in 23 innings this season with a 1-0 record.
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Arizona Diamondbacks vs Chicago White Sox Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
8
|
0.531 | 81 | 43 | 38 |
|
13
|
0.5 | 82 | 41 | 41 |
Arizona Diamondbacks and Chicago White Sox Latest Matches
4/6 (67%)
2/6 (33%)
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4/6 (67%)
2/6 (33%)
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4/6 (67%)
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3/6 (50%)
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0/6 (0%)
6/6 (100%)
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4/6 (67%)
2/6 (33%)
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Arizona Diamondbacks against Chicago White Sox : Head to Head (H2H)
25 %
75 %
Apr 21, 2026 - MLB
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Arizona Diamondbacks - Chicago White Sox Key Points
- The White Sox's collective batting average is the third lowest in MLB at .218.
- The Diamondbacks have a 4-3 record in Game 2 of their series this season
- Baldwin and Hays are among the White Sox's injured players
- The White Sox are allowing an average of 5.1 runs per game
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Our Arizona Diamondbacks vs Chicago White Sox Prediction
Eduardo Rodríguez could very well bring the White Sox's offense back down to earth; he has done so before, as he is 5-0 against the South Side team. The left-hander seems to be using his changeup more and more, an adjustment that appears to be paying off handsomely.
The D-backs' offense in the early part of the season has been inconsistent. The face of the team: Caroll is batting .288, with 3 triples and 13 walks. Kay will be pitching for the White Sox, and this looks like a good opportunity for him to take over the Arizona major league job.
Our prediction for the Diamondbacks vs White Sox is: Diamondbacks ML.
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