St. Louis Cardinals vs Chicago Cubs Prediction & Picks - MLB
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by Carlos Zabala | in MLB Picks
These Cubs are definitely a streaky team. They had two impressive winning streaks of more than 10 consecutive victories each. However, from May 16 to 26, they went through a 10-game losing streak that began when they lost their last two games against their crosstown rivals, the White Sox.
Nevertheless, even though the Pirates blew them out in Game 2, they lost 1-12; they managed to split the four-game series. During the losing streak, there were many defensive errors, including some costly ones by CF Crow Armstrong, but the inability of the entire lineup to hit with runners in scoring position was also noted.
But the Cubs finally rallied on May 27 and 28. First, they beat the Pirates 10-4 in a game where Happ hit a home run that drove in Bregman and Busch, and Conforto hit one that drove in Suzuki. The Japanese pitcher went 2-for-5 and drove in two runs the following day as the Cubs also won 7-2 thanks to a strong performance from Colin Rea on the mound.
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St. Louis Cardinals vs Chicago Cubs Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
5
|
0.563 | 96 | 54 | 42 |
|
9
|
0.526 | 95 | 50 | 45 |
St. Louis Cardinals and Chicago Cubs Latest Matches
1/6 (17%)
5/6 (83%)
May 27, 2026 - MLB
May 26, 2026 - MLB
May 25, 2026 - MLB
May 23, 2026 - MLB
May 23, 2026 - MLB
May 21, 2026 - MLB
3/6 (50%)
3/6 (50%)
May 21, 2026 - MLB
May 20, 2026 - MLB
May 19, 2026 - MLB
May 17, 2026 - MLB
May 16, 2026 - MLB
May 15, 2026 - MLB
2/6 (33%)
4/6 (67%)
May 27, 2026 - MLB
May 26, 2026 - MLB
May 25, 2026 - MLB
May 23, 2026 - MLB
May 23, 2026 - MLB
May 14, 2026 - MLB
2/6 (33%)
4/6 (67%)
May 28, 2026 - MLB
May 27, 2026 - MLB
May 26, 2026 - MLB
May 25, 2026 - MLB
May 24, 2026 - MLB
May 23, 2026 - MLB
0/6 (0%)
6/6 (100%)
May 24, 2026 - MLB
May 23, 2026 - MLB
May 22, 2026 - MLB
May 20, 2026 - MLB
May 19, 2026 - MLB
May 18, 2026 - MLB
2/6 (33%)
4/6 (67%)
May 28, 2026 - MLB
May 27, 2026 - MLB
May 26, 2026 - MLB
May 25, 2026 - MLB
May 17, 2026 - MLB
May 16, 2026 - MLB
St. Louis Cardinals against Chicago Cubs : Head to Head (H2H)
33 %
67 %
Sep 28, 2025 - MLB
Sep 27, 2025 - MLB
Sep 26, 2025 - MLB
Aug 10, 2025 - MLB
Aug 9, 2025 - MLB
Aug 8, 2025 - MLB
St. Louis Cardinals - Chicago Cubs Key Points
- The Cubs' on-base percentage is second-best in MLB at .336
- The Cubs have won their last three games against the Cardinals, all in 2025
- The Cubs' record against divisional rivals is 7-7, the same as the Cardinals
- The Cardinals' record at Busch Stadium is 13-13
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Our St. Louis Cardinals vs Chicago Cubs Prediction
The Cardinals and Cubs then begin a heated weekend series in St. Louis. The Cubs will start their Japanese pitcher Shota Imanaga, hoping to recover from two poor outings in which he allowed eight earned runs to the Brewers and another seven to the Astros six days later; both games were at Wrigley Field.
The Cardinals, in the midst of a four-game losing streak against divisional rivals, will start Kyle Leahy. He has allowed 8 home runs in 50.2 innings this season; the Reds managed 5 earned runs off him in 5 innings on May 23.
Our prediction for Cardinals vs Cubs is: Over 8 runs.
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