St. Louis Cardinals vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
5/29/26 19:15
Chicago Cubs

Prediction:

 

Over 8 runs.

-112
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 by Carlos Zabala | in MLB Picks

These Cubs are definitely a streaky team. They had two impressive winning streaks of more than 10 consecutive victories each. However, from May 16 to 26, they went through a 10-game losing streak that began when they lost their last two games against their crosstown rivals, the White Sox.

Nevertheless, even though the Pirates blew them out in Game 2, they lost 1-12; they managed to split the four-game series. During the losing streak, there were many defensive errors, including some costly ones by CF Crow Armstrong, but the inability of the entire lineup to hit with runners in scoring position was also noted.

But the Cubs finally rallied on May 27 and 28. First, they beat the Pirates 10-4 in a game where Happ hit a home run that drove in Bregman and Busch, and Conforto hit one that drove in Suzuki. The Japanese pitcher went 2-for-5 and drove in two runs the following day as the Cubs also won 7-2 thanks to a strong performance from Colin Rea on the mound.

St. Louis Cardinals vs Chicago Cubs Form

Table

Teams Pts P W L
5 Chicago Cubs
0.563 96 54 42
9 St. Louis Cardinals
0.526 95 50 45

St. Louis Cardinals and Chicago Cubs Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 27, 2026 - MLB

Milwaukee Brewers
2 :  1
St. Louis Cardinals

May 26, 2026 - MLB

Milwaukee Brewers
6 :  0
St. Louis Cardinals

May 25, 2026 - MLB

Milwaukee Brewers
5 :  1
St. Louis Cardinals

May 23, 2026 - MLB

Cincinnati Reds
7 :  6
St. Louis Cardinals

May 23, 2026 - MLB

Cincinnati Reds
1 :  8
St. Louis Cardinals

May 21, 2026 - MLB

St. Louis Cardinals
2 :  6
Pittsburgh Pirates
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 21, 2026 - MLB

St. Louis Cardinals
2 :  6
Pittsburgh Pirates

May 20, 2026 - MLB

St. Louis Cardinals
0 :  7
Pittsburgh Pirates

May 19, 2026 - MLB

St. Louis Cardinals
9 :  6
Pittsburgh Pirates

May 17, 2026 - MLB

St. Louis Cardinals
0 :  2
Kansas City Royals

May 16, 2026 - MLB

St. Louis Cardinals
4 :  2
Kansas City Royals

May 15, 2026 - MLB

St. Louis Cardinals
5 :  4
Kansas City Royals
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 27, 2026 - MLB

Milwaukee Brewers
2 :  1
St. Louis Cardinals

May 26, 2026 - MLB

Milwaukee Brewers
6 :  0
St. Louis Cardinals

May 25, 2026 - MLB

Milwaukee Brewers
5 :  1
St. Louis Cardinals

May 23, 2026 - MLB

Cincinnati Reds
7 :  6
St. Louis Cardinals

May 23, 2026 - MLB

Cincinnati Reds
1 :  8
St. Louis Cardinals

May 14, 2026 - MLB

Athletics
4 :  5
St. Louis Cardinals
Chicago Cubs
Chicago Cubs Latest matches
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 28, 2026 - MLB

Pittsburgh Pirates
2 :  7
Chicago Cubs

May 27, 2026 - MLB

Pittsburgh Pirates
4 :  10
Chicago Cubs

May 26, 2026 - MLB

Pittsburgh Pirates
12 :  1
Chicago Cubs

May 25, 2026 - MLB

Pittsburgh Pirates
2 :  1
Chicago Cubs

May 24, 2026 - MLB

Chicago Cubs
5 :  8
Houston Astros

May 23, 2026 - MLB

Chicago Cubs
0 :  3
Houston Astros
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

May 24, 2026 - MLB

Chicago Cubs
5 :  8
Houston Astros

May 23, 2026 - MLB

Chicago Cubs
0 :  3
Houston Astros

May 22, 2026 - MLB

Chicago Cubs
2 :  4
Houston Astros

May 20, 2026 - MLB

Chicago Cubs
0 :  5
Milwaukee Brewers

May 19, 2026 - MLB

Chicago Cubs
2 :  5
Milwaukee Brewers

May 18, 2026 - MLB

Chicago Cubs
3 :  9
Milwaukee Brewers
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 28, 2026 - MLB

Pittsburgh Pirates
2 :  7
Chicago Cubs

May 27, 2026 - MLB

Pittsburgh Pirates
4 :  10
Chicago Cubs

May 26, 2026 - MLB

Pittsburgh Pirates
12 :  1
Chicago Cubs

May 25, 2026 - MLB

Pittsburgh Pirates
2 :  1
Chicago Cubs

May 17, 2026 - MLB

Chicago White Sox
9 :  8
Chicago Cubs

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

St. Louis Cardinals against Chicago Cubs : Head to Head (H2H)

St. Louis Cardinals

33 %

Chicago Cubs

67 %

Sep 28, 2025 - MLB

Chicago Cubs
2 :  0
St. Louis Cardinals

Sep 27, 2025 - MLB

Chicago Cubs
7 :  3
St. Louis Cardinals

Sep 26, 2025 - MLB

Chicago Cubs
12 :  1
St. Louis Cardinals

Aug 10, 2025 - MLB

St. Louis Cardinals
3 :  2
Chicago Cubs

Aug 9, 2025 - MLB

St. Louis Cardinals
1 :  9
Chicago Cubs

Aug 8, 2025 - MLB

St. Louis Cardinals
5 :  0
Chicago Cubs
St. Louis Cardinals vs Chicago Cubs Picks

St. Louis Cardinals - Chicago Cubs Key Points

  1. The Cubs' on-base percentage is second-best in MLB at .336
  2. The Cubs have won their last three games against the Cardinals, all in 2025
  3. The Cubs' record against divisional rivals is 7-7, the same as the Cardinals
  4. The Cardinals' record at Busch Stadium is 13-13

Our St. Louis Cardinals vs Chicago Cubs Prediction

The Cardinals and Cubs then begin a heated weekend series in St. Louis. The Cubs will start their Japanese pitcher Shota Imanaga, hoping to recover from two poor outings in which he allowed eight earned runs to the Brewers and another seven to the Astros six days later; both games were at Wrigley Field.

The Cardinals, in the midst of a four-game losing streak against divisional rivals, will start Kyle Leahy. He has allowed 8 home runs in 50.2 innings this season; the Reds managed 5 earned runs off him in 5 innings on May 23.

Our prediction for Cardinals vs Cubs is: Over 8 runs.

Prediction:

 

Over 8 runs.

-112
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