St. Louis Cardinals vs Chicago Cubs Prediction & Picks - MLB

Prediction published on 8/8/25, 5:14 PM  by Carlos Zabala | Modified on 8/8/25 at 11:00 PM in MLB Picks

At Busch Stadium, the Cardinals and Cubs continue their rivalry, with the Cubs second in their division with a 66-48 record, being displaced by the Brewers, and the Cardinals fourth in their division with a 58-58 record in 2025.

The Cubs failed to win their last series at Wrigley Field, and concern is growing about Tucker's offensive decline, as he was given an extra day of rest on Wednesday. Since suffering a finger injury, his numbers have dipped a bit, but Tucker dismissed that, saying he's fine about it. Seiya Suzuki, who hit his 27th home run, did contribute to avoiding a sweep, and when he does that, the Cubs usually win. Ian Happ also hit his 16th home run, and Swanson his 18th in a game that could change the course of the month.

The Cubs and Cardinals already played their first series in St. Louis, which went four games and they split. Boyd pitched one of the Cubs' winning games; he pitched six scoreless innings against the Cards in a game the Cubs won 8-0, in which they had come out as -148 favorites.