San Francisco Giants vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

San Francisco Giants
6/12/26 22:15
Chicago Cubs

Prediction:

 

The Giants -1.5 Runs

+180
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 by Lou Aguila in MLB Picks

Boasting a 7-3 record in their last 10 games against the Chicago Cubs, the San Francisco Giants seek another convincing win over this skidding NL Central team in Game 1 on Friday at Oracle Park.

Momentum: The Chicago Cubs snapped a three-game losing streak with a 9-3 win over the Colorado Rockies in Thursday’s series finale. The Cubs are 2-3 in their last five games. The San Francisco Giants also prevented a sweep after gutting out an 11-10 win over the Washington Nationals.

The Matchup: The Giants have owned the Cubs in their recent series. San Francisco holds a 7-3 record in the last 10 meetings with Chicago. In their last three games, the Giants have outscored the Cubs by an average of 7.3 runs to 2.3 runs per game.

Starting Pitchers: Cubs RHP Javier Assad (3-1, 4.73 ERA) will be making his first start since giving up one earned run over 5.2 innings in a 2-1 win over the Mets on April 19.

Giants RHP Landen Roupp (5-6, 4.00 ERA) surrendered one earned run over 5.2 innings pitched in a 3-2 win over San Francisco on June 6.

Hot on the Board: The Giants are +180 to cover -1.5 runs against the Cubs. Out of their last 7 wins over Chicago, San Francisco won by at least 2 runs in five of those games.

Up to $250 to bet on San Francisco Giants - Chicago Cubs! 

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San Francisco Giants vs Chicago Cubs Form

Table

Teams Pts P W L
12 Chicago Cubs
0.507 69 35 34
27 San Francisco Giants
0.406 69 28 41

San Francisco Giants and Chicago Cubs Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 10, 2026 - MLB

San Francisco Giants
11 :  10
Washington Nationals

Jun 9, 2026 - MLB

San Francisco Giants
3 :  6
Washington Nationals

Jun 8, 2026 - MLB

San Francisco Giants
3 :  4
Washington Nationals

Jun 7, 2026 - MLB

Chicago Cubs
1 :  2
San Francisco Giants

Jun 6, 2026 - MLB

Chicago Cubs
3 :  2
San Francisco Giants

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Jun 10, 2026 - MLB

San Francisco Giants
11 :  10
Washington Nationals

Jun 9, 2026 - MLB

San Francisco Giants
3 :  6
Washington Nationals

Jun 8, 2026 - MLB

San Francisco Giants
3 :  4
Washington Nationals

May 27, 2026 - MLB

San Francisco Giants
2 :  3
Arizona Diamondbacks

May 26, 2026 - MLB

San Francisco Giants
5 :  7
Arizona Diamondbacks

May 25, 2026 - MLB

San Francisco Giants
2 :  6
Arizona Diamondbacks
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 7, 2026 - MLB

Chicago Cubs
1 :  2
San Francisco Giants

Jun 6, 2026 - MLB

Chicago Cubs
3 :  2
San Francisco Giants

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants

Jun 4, 2026 - MLB

Milwaukee Brewers
9 :  12
San Francisco Giants

Jun 3, 2026 - MLB

Milwaukee Brewers
0 :  1
San Francisco Giants

Jun 2, 2026 - MLB

Milwaukee Brewers
8 :  3
San Francisco Giants
Chicago Cubs
Chicago Cubs Latest matches
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 11, 2026 - MLB

Colorado Rockies
3 :  9
Chicago Cubs

Jun 10, 2026 - MLB

Colorado Rockies
3 :  2
Chicago Cubs

Jun 9, 2026 - MLB

Colorado Rockies
7 :  3
Chicago Cubs

Jun 7, 2026 - MLB

Chicago Cubs
1 :  2
San Francisco Giants

Jun 6, 2026 - MLB

Chicago Cubs
3 :  2
San Francisco Giants

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 7, 2026 - MLB

Chicago Cubs
1 :  2
San Francisco Giants

Jun 6, 2026 - MLB

Chicago Cubs
3 :  2
San Francisco Giants

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants

Jun 4, 2026 - MLB

Chicago Cubs
7 :  6
Athletics

Jun 3, 2026 - MLB

Chicago Cubs
4 :  5
Athletics

Jun 2, 2026 - MLB

Chicago Cubs
1 :  2
Athletics
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 11, 2026 - MLB

Colorado Rockies
3 :  9
Chicago Cubs

Jun 10, 2026 - MLB

Colorado Rockies
3 :  2
Chicago Cubs

Jun 9, 2026 - MLB

Colorado Rockies
7 :  3
Chicago Cubs

May 31, 2026 - MLB

St. Louis Cardinals
5 :  1
Chicago Cubs

May 30, 2026 - MLB

St. Louis Cardinals
1 :  6
Chicago Cubs

May 29, 2026 - MLB

St. Louis Cardinals
6 :  5
Chicago Cubs

San Francisco Giants against Chicago Cubs : Head to Head (H2H)

San Francisco Giants

83 %

Chicago Cubs

17 %

Jun 7, 2026 - MLB

Chicago Cubs
1 :  2
San Francisco Giants

Jun 6, 2026 - MLB

Chicago Cubs
3 :  2
San Francisco Giants

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants

Mar 8, 2026 - MLB Spring Training

Chicago Cubs
5 :  9
San Francisco Giants

Feb 22, 2026 - MLB Spring Training

San Francisco Giants
4 :  2
Chicago Cubs

Aug 28, 2025 - MLB

San Francisco Giants
4 :  3
Chicago Cubs

San Francisco Giants - Chicago Cubs Key Points

  1. Chicago Cubs is 1-7 SU in its last 8 games against San Francisco.
  2. Chicago Cubs is 1-7 SU in its last 8 games when playing on the road against San Francisco.
  3. San Francisco won by at least 2 runs in five of their last 7 wins over the Cubs
  4. San Francisco is 7-3 in their last 10 games against the Cubs
Up to $250 to bet on San Francisco Giants - Chicago Cubs! 

Limited Offer. Currently at Caesars Sportsbook

Our San Francisco Giants vs Chicago Cubs Prediction

The Giants will assert their mastery over the Cubs to bag another ATS win.

San Francisco will bank on their home-court advantage and Roupp, who has allowed a total of 3 earned runs over 15 innings pitched against the Cubs.

San Francisco’s offense has produced stronger numbers this week. The Giants have hit .251 with 4.1 runs per game over their last five games, while the Cubs have batted .229 with 3.5 runs per game in their last five games.

And while the record suggests that the Cubs should be a better team than San Francisco, their head-to-head record in the last 10 meetings tells a different story.

This is a good example of a good team running into a bad matchup.

Our betting prediction for the Chicago Cubs vs. the San Francisco Giants: The Giants -1.5 runs

Prediction:

 

The Giants -1.5 Runs

+180
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San Francisco Giants vs Chicago Cubs Picks