San Francisco Giants vs Chicago Cubs Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Lou Aguila in MLB Picks
Boasting a 7-3 record in their last 10 games against the Chicago Cubs, the San Francisco Giants seek another convincing win over this skidding NL Central team in Game 1 on Friday at Oracle Park.
Momentum: The Chicago Cubs snapped a three-game losing streak with a 9-3 win over the Colorado Rockies in Thursday’s series finale. The Cubs are 2-3 in their last five games. The San Francisco Giants also prevented a sweep after gutting out an 11-10 win over the Washington Nationals.
The Matchup: The Giants have owned the Cubs in their recent series. San Francisco holds a 7-3 record in the last 10 meetings with Chicago. In their last three games, the Giants have outscored the Cubs by an average of 7.3 runs to 2.3 runs per game.
Starting Pitchers: Cubs RHP Javier Assad (3-1, 4.73 ERA) will be making his first start since giving up one earned run over 5.2 innings in a 2-1 win over the Mets on April 19.
Giants RHP Landen Roupp (5-6, 4.00 ERA) surrendered one earned run over 5.2 innings pitched in a 3-2 win over San Francisco on June 6.
Hot on the Board: The Giants are +180 to cover -1.5 runs against the Cubs. Out of their last 7 wins over Chicago, San Francisco won by at least 2 runs in five of those games.
Limited Offer. Currently at Caesars Sportsbook
San Francisco Giants vs Chicago Cubs Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
12
|
0.507 | 69 | 35 | 34 |
|
27
|
0.406 | 69 | 28 | 41 |
San Francisco Giants and Chicago Cubs Latest Matches
3/6 (50%)
3/6 (50%)
Jun 10, 2026 - MLB
Jun 9, 2026 - MLB
Jun 8, 2026 - MLB
Jun 7, 2026 - MLB
Jun 6, 2026 - MLB
Jun 5, 2026 - MLB
1/6 (17%)
5/6 (83%)
Jun 10, 2026 - MLB
Jun 9, 2026 - MLB
Jun 8, 2026 - MLB
May 27, 2026 - MLB
May 26, 2026 - MLB
May 25, 2026 - MLB
4/6 (67%)
2/6 (33%)
Jun 7, 2026 - MLB
Jun 6, 2026 - MLB
Jun 5, 2026 - MLB
Jun 4, 2026 - MLB
Jun 3, 2026 - MLB
Jun 2, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 11, 2026 - MLB
Jun 10, 2026 - MLB
Jun 9, 2026 - MLB
Jun 7, 2026 - MLB
Jun 6, 2026 - MLB
Jun 5, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 7, 2026 - MLB
Jun 6, 2026 - MLB
Jun 5, 2026 - MLB
Jun 4, 2026 - MLB
Jun 3, 2026 - MLB
Jun 2, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 11, 2026 - MLB
Jun 10, 2026 - MLB
Jun 9, 2026 - MLB
May 31, 2026 - MLB
May 30, 2026 - MLB
May 29, 2026 - MLB
San Francisco Giants against Chicago Cubs : Head to Head (H2H)
83 %
17 %
Jun 7, 2026 - MLB
Jun 6, 2026 - MLB
Jun 5, 2026 - MLB
Mar 8, 2026 - MLB Spring Training
Feb 22, 2026 - MLB Spring Training
Aug 28, 2025 - MLB
San Francisco Giants - Chicago Cubs Key Points
- Chicago Cubs is 1-7 SU in its last 8 games against San Francisco.
- Chicago Cubs is 1-7 SU in its last 8 games when playing on the road against San Francisco.
- San Francisco won by at least 2 runs in five of their last 7 wins over the Cubs
- San Francisco is 7-3 in their last 10 games against the Cubs
Limited Offer. Currently at Caesars Sportsbook
Our San Francisco Giants vs Chicago Cubs Prediction
The Giants will assert their mastery over the Cubs to bag another ATS win.
San Francisco will bank on their home-court advantage and Roupp, who has allowed a total of 3 earned runs over 15 innings pitched against the Cubs.
San Francisco’s offense has produced stronger numbers this week. The Giants have hit .251 with 4.1 runs per game over their last five games, while the Cubs have batted .229 with 3.5 runs per game in their last five games.
And while the record suggests that the Cubs should be a better team than San Francisco, their head-to-head record in the last 10 meetings tells a different story.
This is a good example of a good team running into a bad matchup.
Our betting prediction for the Chicago Cubs vs. the San Francisco Giants: The Giants -1.5 runs
A 2026 WC Welcome Bonus for San Francisco Giants vs Chicago Cubs!

Thanks to our code: STRADERDYW, you can unlock $250 available for use on this San Francisco Giants vs Chicago Cubs matchup!
This offer is only available for new sign-ups, but it remains one of the highest welcome bonuses currently on offer. Take advantage before it goes away!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.