USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Lou Aguila in MLB Picks
The San Francisco Giants, listed as +104 underdogs, will go for their fourth win in a row against the Chicago Cubs in Wednesday’s Game 2 at Oracle Park.
The Giants carried over the momentum from their back-to-back wins over the Milwaukee Brewers into Tuesday’s series opener against the Cubs. Future Hall of Famer Justin Verlander threw for six innings, surrendering two earned runs and seven hits to earn his first career win since joining the Giants. Third baseman Matt Chapman delivered a two-run blast in the 6th inning to cap a 4-0 run by the Giants in the fifth and sixth innings. The win improved the Giants’ regular-season record to 64-68, third in the NL West behind World Series contenders LA Dodgers (75-57) and the San Diego Padres (74-58).
As for the Cubs, the loss increased the Brewers’ lead on them to 6.5 games with roughly a month left in the regular season. The Cubs, who dominated the Los Angeles Angels in the previous series, are 2-6 in their last eight meetings with the Giants. It would be interesting to see how Chicago will bounce back from this setback in Game 2.
Limited Offer. Currently at Caesars Sportsbook
Chicago Cubs vs San Francisco Giants Form
Table
| Teams | % | P | W | L |
|---|---|---|---|---|
|
4
|
0.576 | 132 | 76 | 56 |
|
18
|
0.485 | 132 | 64 | 68 |
Chicago Cubs and San Francisco Giants Latest Matches
4/6 (67%)
2/6 (33%)
Aug 26, 2025 - MLB
Aug 24, 2025 - MLB
Aug 23, 2025 - MLB
Aug 22, 2025 - MLB
Aug 21, 2025 - MLB
Aug 20, 2025 - MLB
4/6 (67%)
2/6 (33%)
Aug 21, 2025 - MLB
Aug 20, 2025 - MLB
Aug 19, 2025 - MLB
Aug 19, 2025 - MLB
Aug 18, 2025 - MLB
Aug 17, 2025 - MLB
4/6 (67%)
2/6 (33%)
Aug 26, 2025 - MLB
Aug 24, 2025 - MLB
Aug 23, 2025 - MLB
Aug 22, 2025 - MLB
Aug 14, 2025 - MLB
Aug 13, 2025 - MLB
3/6 (50%)
3/6 (50%)
Aug 26, 2025 - MLB
Aug 24, 2025 - MLB
Aug 23, 2025 - MLB
Aug 22, 2025 - MLB
Aug 21, 2025 - MLB
Aug 20, 2025 - MLB
2/6 (33%)
4/6 (67%)
Aug 26, 2025 - MLB
Aug 17, 2025 - MLB
Aug 16, 2025 - MLB
Aug 15, 2025 - MLB
Aug 13, 2025 - MLB
Aug 12, 2025 - MLB
2/6 (33%)
4/6 (67%)
Aug 24, 2025 - MLB
Aug 23, 2025 - MLB
Aug 22, 2025 - MLB
Aug 21, 2025 - MLB
Aug 20, 2025 - MLB
Aug 19, 2025 - MLB
Chicago Cubs against San Francisco Giants : Head to Head (H2H)
17 %
83 %
Aug 26, 2025 - MLB
May 7, 2025 - MLB
May 6, 2025 - MLB
May 5, 2025 - MLB
Mar 9, 2025 - MLB Spring Training
Feb 26, 2025 - MLB Spring Training
Chicago Cubs - San Francisco Giants Key Points
- Chicago Cubs is 1-5 SU in its last 6 games when playing on the road against San Francisco.
- Chicago Cubs is 2-6 SU in its last 8 games against San Francisco.
- San Francisco is 5-1 SU in its last 6 games when playing at home against Chicago Cubs.
- San Francisco is 5-11 SU in its last 16 games.
Limited Offer. Currently at Caesars Sportsbook
Our Chicago Cubs vs San Francisco Giants Prediction
The Giants will beat the Cubs again behind another masterful performance from their pitching staff.
San Francisco is 4-1 in its last 5 games when playing at home against the Chicago Cubs. Moreover, the Giants will be starting a lefty in Game 2. Carson Whisenhunt (1-1, 4,91 ERA) hopes he can neutralize a Cubs offense, which is producing 1.7 runs per game in the last five games against left-handed pitchers. In their last three meetings with the Cubs, San Francisco has averaged 6.3 runs per game and held Chicago to 5.0 runs per game.
The Chicago Cubs are 2-6 in their last 8 games against San Francisco and 1-4 in their last 5 games when playing on the road against the said team. Colin Rea is an excellent pitcher with a 3-2 record and a 3.55 ERA in his last five starts. However, he has lost his last two faceoffs with the Giants, yielding a total of 15 runs over 9.0 innings pitched. Although Rea can put together a strong mound appearance anytime, I just can’t trust him to put up terrific numbers against the team that has given him headaches in the past. Moreover, Rea cannot allow the Giants to take a significant lead into the late innings because their bullpen is only giving up 1.98 ERA in the last five games.
Our betting prediction for the Chicago Cubs vs. the San Francisco Giants: the Giants will win.
Right now, claim $250 for your Chicago Cubs vs San Francisco Giants wager!
Caesars Sportsbook is offering an extraordinary opportunity for new bettors with $250 in bonus bets! You can access this promo for the Chicago Cubs vs San Francisco Giants matchup!
New users can access the bonus on Caesars Sportsbook Mobile or through the website by creating an account during the promotion period and registering using a special promo code. This offer is a chance for newcomers to experience the thrill of sports betting with a significant Bonus Bet, courtesy of Caesars Sportsbook.
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
Limited Offer. Currently at Caesars Sportsbook
