San Diego Padres vs Chicago Cubs Prediction & Picks - MLB
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by Stephen Abiola | in MLB Picks
San Diego Padres (18-9) and Chicago Cubs (17-11) will meet under the lights at Petco Park on Monday night. The Padres will want to start this series with a win and recover from their heavy 12-7 loss over the D-Backs. It was a disappointing performance by the Padres, who surrendered a 6-0 lead to Arizona. This sort of performance could certainly affect the team’s morale if they don’t bounce back immediately with a win.
The Cubs, meanwhile, are coming off a taxing 2-1 series loss to Los Angeles Dodgers. They started this three-game series with a bang, winning 6-4 in their first game. However, they looked out of their depth in the last two matches, scoring only 4 runs while conceding 20. Even more painful is that these losses ended their 10-game winning streak. They’ll be under immense pressure to respond with a win tonight.
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San Diego Padres vs Chicago Cubs Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
7
|
0.542 | 83 | 45 | 38 |
|
8
|
0.531 | 81 | 43 | 38 |
San Diego Padres and Chicago Cubs Latest Matches
4/6 (67%)
2/6 (33%)
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6/6 (100%)
0/6 (0%)
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4/6 (67%)
2/6 (33%)
Apr 26, 2026 - MLB
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4/6 (67%)
2/6 (33%)
Apr 26, 2026 - MLB
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6/6 (100%)
0/6 (0%)
Apr 23, 2026 - MLB
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3/6 (50%)
3/6 (50%)
Apr 26, 2026 - MLB
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San Diego Padres against Chicago Cubs : Head to Head (H2H)
50 %
50 %
Mar 6, 2026 - MLB Spring Training
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San Diego Padres - Chicago Cubs Key Points
- The total runs went over 7.5 in nine of the last 10 Chicago Cubs away games.
- The total runs went over in five of the last six Chicago Cubs matches.
- The total runs went over 7.5 in the last four San Diego Padres matches.
- The total runs went over 7.5 in four of the last seven San Diego Padres home games.
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Our San Diego Padres vs Chicago Cubs Prediction
The Cubs are the warm -120 betting favorites. Despite their recent underwhelming performances, they’ve been impressive in attack, boasting a batting average of .263, which is third in baseball. They’ve also scored 57 home runs this season, which is fifth in baseball. However, the Padres have also been productive in attack, scoring 23 runs in their last three matches. The hosts are solid at home, going 9-4 this season and winning their last eight matches. We, therefore, expect both sides to play aggressively, with the total runs going over. The Padres will start the reliable Randy Vasquez (2-0, 1.88 ERA), whereas the Cups will play Matthew Boyd (1-1, 5.79 ERA). These statistics give the Padres a slight edge.
Our prediction for San Diego Padres vs Chicago Cubs: Over 7.5 runs.
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
