Pittsburgh Pirates vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

Pittsburgh Pirates
7/24/26 18:40
Chicago Cubs

Prediction:

 

Cubs ML

+102
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 by Travis Pulver | in MLB Picks

The Pittsburgh Pirates (53-50, 27-24 Home) will host the Chicago Cubs in a three-game weekend series starting with Game 1 today at PNC Park. First Pitch is scheduled for 6:40 p.m. EST with coverage provided by MLB.TV.

Division rivals, the Cubs and Pirates, have already faced off seven times this season. Pittsburgh won the series in Chicago, 2-1, but the two teams split the four-game series in Pittsburgh in late May.

Pittsburgh is scheduled to send Jared Jones to the mound to start the day. Jones is 2-1 in nine starts with a 4.05 ERA and a 1.10 WHIP. He has had four starts at home but has yet to factor into a decision at PNC Park. But he has a 4.74 ERA pitching at home and a .200 OBA. In his last home start, he pitched six shutout innings against the Braves, but the Pirates ultimately lost the game, 3-0.

As for the Cubbies, Chicago is scheduled to start Matthew Boyd. He has gone 6-1 in ten starts with a 4.15 ERA and a 1.21 WHIP. Boyd has done some of his better work on the road, where he is 2-0 in four starts with a 3.86 ERA and a .256 OBA.

Pittsburgh Pirates vs Chicago Cubs Form

Table

Teams Pts P W L
5 Chicago Cubs
0.58 119 69 50
20 Pittsburgh Pirates
0.483 120 58 62

Pittsburgh Pirates and Chicago Cubs Latest Matches

Pittsburgh Pirates
Pittsburgh Pirates Latest matches
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 22, 2026 - MLB

New York Yankees
2 :  0
Pittsburgh Pirates

Jul 22, 2026 - MLB

New York Yankees
3 :  5
Pittsburgh Pirates

Jul 20, 2026 - MLB

New York Yankees
8 :  5
Pittsburgh Pirates

Jul 19, 2026 - MLB

Cleveland Guardians
1 :  7
Pittsburgh Pirates

Jul 18, 2026 - MLB

Cleveland Guardians
5 :  3
Pittsburgh Pirates

Jul 18, 2026 - MLB

Cleveland Guardians
1 :  7
Pittsburgh Pirates
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jul 12, 2026 - MLB

Pittsburgh Pirates
14 :  5
Milwaukee Brewers

Jul 11, 2026 - MLB

Pittsburgh Pirates
3 :  2
Milwaukee Brewers

Jul 11, 2026 - MLB

Pittsburgh Pirates
7 :  6
Milwaukee Brewers

Jul 9, 2026 - MLB

Pittsburgh Pirates
5 :  10
Atlanta Braves

Jul 8, 2026 - MLB

Pittsburgh Pirates
0 :  3
Atlanta Braves

Jul 7, 2026 - MLB

Pittsburgh Pirates
12 :  4
Atlanta Braves
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 22, 2026 - MLB

New York Yankees
2 :  0
Pittsburgh Pirates

Jul 22, 2026 - MLB

New York Yankees
3 :  5
Pittsburgh Pirates

Jul 20, 2026 - MLB

New York Yankees
8 :  5
Pittsburgh Pirates

Jul 19, 2026 - MLB

Cleveland Guardians
1 :  7
Pittsburgh Pirates

Jul 18, 2026 - MLB

Cleveland Guardians
5 :  3
Pittsburgh Pirates

Jul 18, 2026 - MLB

Cleveland Guardians
1 :  7
Pittsburgh Pirates
Chicago Cubs
Chicago Cubs Latest matches
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 22, 2026 - MLB

Chicago Cubs
1 :  5
Detroit Tigers

Jul 21, 2026 - MLB

Chicago Cubs
11 :  2
Detroit Tigers

Jul 20, 2026 - MLB

Chicago Cubs
6 :  8
Detroit Tigers

Jul 19, 2026 - MLB

Chicago Cubs
10 :  1
Minnesota Twins

Jul 18, 2026 - MLB

Chicago Cubs
6 :  2
Minnesota Twins

Jul 17, 2026 - MLB

Chicago Cubs
2 :  5
Minnesota Twins
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 22, 2026 - MLB

Chicago Cubs
1 :  5
Detroit Tigers

Jul 21, 2026 - MLB

Chicago Cubs
11 :  2
Detroit Tigers

Jul 20, 2026 - MLB

Chicago Cubs
6 :  8
Detroit Tigers

Jul 19, 2026 - MLB

Chicago Cubs
10 :  1
Minnesota Twins

Jul 18, 2026 - MLB

Chicago Cubs
6 :  2
Minnesota Twins

Jul 17, 2026 - MLB

Chicago Cubs
2 :  5
Minnesota Twins
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jul 12, 2026 - MLB

Cincinnati Reds
4 :  8
Chicago Cubs

Jul 11, 2026 - MLB

Cincinnati Reds
3 :  5
Chicago Cubs

Jul 10, 2026 - MLB

Cincinnati Reds
4 :  0
Chicago Cubs

Jul 9, 2026 - MLB

Baltimore Orioles
3 :  2
Chicago Cubs

Jul 8, 2026 - MLB

Baltimore Orioles
7 :  9
Chicago Cubs

Jul 7, 2026 - MLB

Baltimore Orioles
2 :  5
Chicago Cubs

Pittsburgh Pirates against Chicago Cubs : Head to Head (H2H)

Pittsburgh Pirates

50 %

Chicago Cubs

50 %

May 28, 2026 - MLB

Pittsburgh Pirates
2 :  7
Chicago Cubs

May 27, 2026 - MLB

Pittsburgh Pirates
4 :  10
Chicago Cubs

May 26, 2026 - MLB

Pittsburgh Pirates
12 :  1
Chicago Cubs

May 25, 2026 - MLB

Pittsburgh Pirates
2 :  1
Chicago Cubs

Apr 12, 2026 - MLB

Chicago Cubs
7 :  6
Pittsburgh Pirates

Apr 11, 2026 - MLB

Chicago Cubs
3 :  4
Pittsburgh Pirates
Pittsburgh Pirates vs Chicago Cubs Picks

Pittsburgh Pirates - Chicago Cubs Key Points

  1. The Pirates lead the all-time series vs. the Cubs, 1321-1290-17.
  2. The Cubs are 25-25 ATS (run line) this season on the road; Pittsburgh is 26-25 ATS (run line) at home.
  3. The OVER is 26-23-1 for the Cubs on the road and 34-17 for the Pirates at home.
  4. Betting Public: 54% of moneyline tickets and 63% of the handle are on the Cubs.

Our Pittsburgh Pirates vs Chicago Cubs Prediction

On the surface, it looks like no one has a pitching advantage since the stats are pretty similar between the two starting pitchers. However, Boyd has progressed to the point where he has been able to go 6+ innings in his last three starts; the team went undefeated in those starts. Jones has allowed two runs and five hits across his last three starts but lasted 4-6 innings. Even if he has a good outing, the bullpen is not great (4.42 ERA; 22nd in the league). Chicago has hit a solid .266 since the break to Pittsburgh’s .229. They’ll win the game, but I wouldn’t count on them to cover the run line.

Our Chicago vs. Pittsburgh Pick: Cubs ML

Prediction:

 

Cubs ML

+102
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.