Houston Astros vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

Houston Astros
6/27/25 20:10
Chicago Cubs

Prediction:

 

Houston Astros win both halves

-110
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 by Erik Gibbs | in MLB Picks

The Houston Astros and Chicago Cubs will meet today at Daikin Park in an interleague clash that sees two playoff hopefuls from opposite leagues trying to build momentum as the season approaches its midpoint.

The Chicago Cubs hold a 48-33 record after finishing a four-game set against the Cardinals with a split, posting results of 2-8, 7-8, 8-0, and 3-0. They'll continue their road trip on Friday, where they've been decent but not dominant, sitting four games over .500 away from home.

Before facing St. Louis, the Cubs dropped two of three games to the Mariners and split a brief two-game series with the Brewers. They've gone 3-3 over their last six contests and currently lead the NL Central.

Meanwhile, the Houston Astros also sit at 48-33 following a sweep of the Phillies. In the third game of that series, they gave up a tying run in the eighth but answered with a go-ahead score in the bottom half to seal the win.

Leading into that matchup, Houston took two of three from the Angels and split a four-game series with the Athletics. The Astros come into this weekend riding a four-game win streak and sit atop the AL West standings.

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Houston Astros vs Chicago Cubs Form

Table

Teams Pts P W L
6 Chicago Cubs
0.568 162 92 70
12 Houston Astros
0.537 162 87 75

Houston Astros and Chicago Cubs Latest Matches

Houston Astros
Houston Astros Latest matches
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jun 26, 2025 - MLB

Houston Astros
2 :  1
Philadelphia Phillies

Jun 25, 2025 - MLB

Houston Astros
2 :  0
Philadelphia Phillies

Jun 24, 2025 - MLB

Houston Astros
1 :  0
Philadelphia Phillies

Jun 22, 2025 - MLB

Los Angeles Angels
7 :  8
Houston Astros

Jun 21, 2025 - MLB

Los Angeles Angels
9 :  1
Houston Astros

Jun 20, 2025 - MLB

Los Angeles Angels
2 :  3
Houston Astros
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Jun 26, 2025 - MLB

Houston Astros
2 :  1
Philadelphia Phillies

Jun 25, 2025 - MLB

Houston Astros
2 :  0
Philadelphia Phillies

Jun 24, 2025 - MLB

Houston Astros
1 :  0
Philadelphia Phillies

Jun 12, 2025 - MLB

Houston Astros
4 :  3
Chicago White Sox

Jun 11, 2025 - MLB

Houston Astros
10 :  2
Chicago White Sox

May 30, 2025 - MLB

Houston Astros
2 :  1
Tampa Bay Rays
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 22, 2025 - MLB

Los Angeles Angels
7 :  8
Houston Astros

Jun 21, 2025 - MLB

Los Angeles Angels
9 :  1
Houston Astros

Jun 20, 2025 - MLB

Los Angeles Angels
2 :  3
Houston Astros

Jun 19, 2025 - MLB

Athletics
6 :  4
Houston Astros

Jun 18, 2025 - MLB

Athletics
4 :  11
Houston Astros

Jun 16, 2025 - MLB

Athletics
3 :  1
Houston Astros
Chicago Cubs
Chicago Cubs Latest matches
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 21, 2025 - MLB

Chicago Cubs
10 :  7
Seattle Mariners

Jun 20, 2025 - MLB

Chicago Cubs
4 :  9
Seattle Mariners

Jun 19, 2025 - MLB

Chicago Cubs
7 :  8
Milwaukee Brewers

Jun 14, 2025 - MLB

Chicago Cubs
2 :  1
Pittsburgh Pirates

Jun 13, 2025 - MLB

Chicago Cubs
1 :  2
Pittsburgh Pirates

Jun 12, 2025 - MLB

Chicago Cubs
3 :  2
Pittsburgh Pirates
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 21, 2025 - MLB

Chicago Cubs
10 :  7
Seattle Mariners

Jun 20, 2025 - MLB

Chicago Cubs
4 :  9
Seattle Mariners

Jun 19, 2025 - MLB

Chicago Cubs
7 :  8
Milwaukee Brewers

Jun 14, 2025 - MLB

Chicago Cubs
2 :  1
Pittsburgh Pirates

Jun 13, 2025 - MLB

Chicago Cubs
1 :  2
Pittsburgh Pirates

Jun 12, 2025 - MLB

Chicago Cubs
3 :  2
Pittsburgh Pirates
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 7, 2025 - MLB

Detroit Tigers
1 :  6
Chicago Cubs

Jun 6, 2025 - MLB

Detroit Tigers
3 :  1
Chicago Cubs

May 24, 2025 - MLB

Cincinnati Reds
6 :  4
Chicago Cubs

May 21, 2025 - MLB

Miami Marlins
1 :  2
Chicago Cubs

May 11, 2025 - MLB

New York Mets
6 :  2
Chicago Cubs

May 10, 2025 - MLB

New York Mets
5 :  6
Chicago Cubs

Houston Astros against Chicago Cubs : Head to Head (H2H)

Houston Astros

0 %

Chicago Cubs

100 %

Apr 24, 2024 - MLB

Chicago Cubs
4 :  3
Houston Astros

Apr 23, 2024 - MLB

Chicago Cubs
7 :  2
Houston Astros

Houston Astros - Chicago Cubs Key Points

  1. The favorites are 10-0 in the Cubs’ last 10 home games
  2. The Astros are 38-43 against the run line
  3. The Cubs are 40-41 against the run line
  4. The Over/Under is 32-45-4 for the Astros
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Our Houston Astros vs Chicago Cubs Prediction

Brandon Walter will likely start the opener for Houston. The rookie left-hander struggled in his last appearance, allowing seven runs over six innings against the Angels and taking the loss.

Despite that outing, he’s shown promise in three of his four starts, giving up two or fewer runs in those games. So far this season, Walter holds a 3.80 ERA, a 1.10 WHIP, and a 0-1 record across 23.1 innings. He faced the Cubs once before, giving up two runs in two innings.

For Chicago, Cade Horton gets the call. The right-hander had a rough outing his last time out but has otherwise impressed in his first MLB season. He owns a 3.48 ERA for the month and a 3.73 ERA with a 1.29 WHIP and a 3-1 record over 41 innings overall. Friday will mark his first career appearance against the Astros.

This game leans Houston’s way, especially given their home-field advantage and pitching matchup. Valdez is the more reliable starter, and the Astros lineup has more firepower top to bottom. While the Cubs have enough talent to pull off an upset, they’ll need early offense and a strong bullpen outing to stay in it. Our prediction for Houston Astros vs. Chicago Cubs: Astros to win.

Prediction:

 

Houston Astros win both halves

-110
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Houston Astros vs Chicago Cubs Picks