Cleveland Guardians vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
4/3/26 16:10
Chicago Cubs

Prediction:

 

Cleveland Guardians on the +1.5 handicap.

-181
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 by Stephen Abiola | in MLB Picks

Cleveland Guardians (4-3) and Chicago Cubs (3-3) will clash on Friday night at Progressive Field. The Guardians find themselves sitting on top of the AL Central standings with a .571 win percentage. They’re yet to taste MLB action at home after sharing the spoils 2-2 with the Mariners in their opening series before edging out the Dodgers 2-1 this week. The Guardians will now be keen to maximize this three-game home series, which ends on Sunday evening.

Chicago Cubs, meanwhile, are third in the NL Central after playing all their first six assignments at home. They’re coming off a spirited 2-1 series win over the Angels, including a 6-2 win in the series finale. It was an impressive outing for the Cubs, who scored a total of 13 runs while giving up only 6. Earlier, the Cubs lost 2-1 to the Nationals in their opening series, scoring 17 runs in the process. This impressive record has their attack sitting sixth in the MLB standings.

Cleveland Guardians vs Chicago Cubs Form

Table

Teams Pts P W L
7 Chicago Cubs
0.542 83 45 38
12 Cleveland Guardians
0.518 83 43 40

Cleveland Guardians and Chicago Cubs Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2026 - MLB

Los Angeles Dodgers
1 :  4
Cleveland Guardians

Mar 31, 2026 - MLB

Los Angeles Dodgers
4 :  1
Cleveland Guardians

Mar 30, 2026 - MLB

Los Angeles Dodgers
2 :  4
Cleveland Guardians

Mar 29, 2026 - MLB

Seattle Mariners
8 :  0
Cleveland Guardians

Mar 28, 2026 - MLB

Seattle Mariners
5 :  6
Cleveland Guardians

Mar 27, 2026 - MLB

Seattle Mariners
5 :  1
Cleveland Guardians
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 22, 2026 - MLB Spring Training

Cleveland Guardians
8 :  2
Cincinnati Reds

Mar 20, 2026 - MLB Spring Training

Cleveland Guardians
8 :  20
Seattle Mariners

Mar 19, 2026 - MLB Spring Training

Cleveland Guardians
6 :  5
Kansas City Royals

Mar 16, 2026 - MLB Spring Training

Cleveland Guardians
2 :  5
Chicago Cubs

Mar 15, 2026 - MLB Spring Training

Cleveland Guardians
12 :  6
Athletics

Mar 12, 2026 - MLB Spring Training

Cleveland Guardians
1 :  0
Milwaukee Brewers
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2026 - MLB

Los Angeles Dodgers
1 :  4
Cleveland Guardians

Mar 31, 2026 - MLB

Los Angeles Dodgers
4 :  1
Cleveland Guardians

Mar 30, 2026 - MLB

Los Angeles Dodgers
2 :  4
Cleveland Guardians

Mar 29, 2026 - MLB

Seattle Mariners
8 :  0
Cleveland Guardians

Mar 28, 2026 - MLB

Seattle Mariners
5 :  6
Cleveland Guardians

Mar 27, 2026 - MLB

Seattle Mariners
5 :  1
Cleveland Guardians
Chicago Cubs
Chicago Cubs Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2026 - MLB

Chicago Cubs
6 :  2
Los Angeles Angels

Mar 31, 2026 - MLB

Chicago Cubs
0 :  2
Los Angeles Angels

Mar 30, 2026 - MLB

Chicago Cubs
7 :  2
Los Angeles Angels

Mar 29, 2026 - MLB

Chicago Cubs
3 :  6
Washington Nationals

Mar 28, 2026 - MLB

Chicago Cubs
10 :  2
Washington Nationals

Mar 26, 2026 - MLB

Chicago Cubs
4 :  10
Washington Nationals
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2026 - MLB

Chicago Cubs
6 :  2
Los Angeles Angels

Mar 31, 2026 - MLB

Chicago Cubs
0 :  2
Los Angeles Angels

Mar 30, 2026 - MLB

Chicago Cubs
7 :  2
Los Angeles Angels

Mar 29, 2026 - MLB

Chicago Cubs
3 :  6
Washington Nationals

Mar 28, 2026 - MLB

Chicago Cubs
10 :  2
Washington Nationals

Mar 26, 2026 - MLB

Chicago Cubs
4 :  10
Washington Nationals
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Mar 21, 2026 - MLB Spring Training

Seattle Mariners
1 :  7
Chicago Cubs

Mar 20, 2026 - MLB Spring Training

Athletics
6 :  2
Chicago Cubs

Mar 18, 2026 - MLB Spring Training

Arizona Diamondbacks
16 :  8
Chicago Cubs

Mar 16, 2026 - MLB Spring Training

Cleveland Guardians
2 :  5
Chicago Cubs

Mar 14, 2026 - MLB Spring Training

Colorado Rockies
4 :  3
Chicago Cubs

Mar 13, 2026 - MLB Spring Training

Chicago White Sox
4 :  2
Chicago Cubs

Cleveland Guardians against Chicago Cubs : Head to Head (H2H)

Cleveland Guardians

17 %

Chicago Cubs

83 %

Mar 16, 2026 - MLB Spring Training

Cleveland Guardians
2 :  5
Chicago Cubs

Feb 27, 2026 - MLB Spring Training

Chicago Cubs
8 :  6
Cleveland Guardians

Jul 3, 2025 - MLB

Chicago Cubs
1 :  0
Cleveland Guardians

Jul 2, 2025 - MLB

Chicago Cubs
5 :  4
Cleveland Guardians

Jul 1, 2025 - MLB

Chicago Cubs
5 :  2
Cleveland Guardians

Aug 13, 2024 - MLB

Cleveland Guardians
2 :  1
Chicago Cubs

Cleveland Guardians - Chicago Cubs Key Points

  1. Cleveland Guardians won with +1.5 runs in their four wins this season.
  2. Chicago Cubs failed to cover the 1.5 handicap in their three defeats this season.
  3. The Guardians are 3-2 in their last five home games against the Guardians.
  4. The Guardians had a 4-5 record against AL Central teams last season.

Our Cleveland Guardians vs Chicago Cubs Prediction

The moneyline odds for this game are -115 for the Cubs and -105 for the Guardians. The Cubs will send Cade Horton (12-4) to the mound. He has a run average of 2.68 and a WHIP of 1.072. Cleveland, on the other hand, will start Joey Cantillo (7-7), who averages 3.74 earned runs and a whip of 1.290. Historically, the Cubs have been dominant in this fixture, winning their last seven meetings. However, we’re backing the Guardians to stop the slide and build on their impressive start to the season. Cleveland will be keen to win their first home game this season and hasn’t played in front of their fans since October last year.

Our prediction for Cleveland Guardians vs Chicago Cubs: ClevelandGuardians on the +1.5 handicap.

Prediction:

 

Cleveland Guardians on the +1.5 handicap.

-181
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Cleveland Guardians vs Chicago Cubs Picks