Chicago White Sox vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

Chicago White Sox
5/17/26 14:10
Chicago Cubs

Prediction:

 

OVER 8.5

-106
$350 offered for betting!

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 by Travis Pulver | in MLB Picks

The Chicago White Sox (23-22, 13-10 Home) will try to make it two in a row when they host their cross-town rivals, the Chicago Cubs, Sunday afternoon at Rate Field in the Windy City. Fans can follow the action on MLB.TV once the game gets underway on 2:10 p.m. EST.

The Cubbies took the first game of this series on Friday, in an exciting 10-5 win that saw the White Sox hit three home runs in a losing effort. Saturday’s game saw both teams combine for six home runs. The White Sox had four of them in an 8-3 win.

Colin Rea is scheduled to start on the mound for the Cubs. Rea has a 4-2 record in nine starts with a 4.68 ERA and a 1.42 WHIP. He has not done his best work on the road (which, technically, this is for him), going 2-2 in five appearances (three starts) with a 6.55 ERA and a .271 OBA.

Erick Fedde is scheduled to start for the White Sox. He has yet to record a win this season, going 0-4 in eight starts with a 3.77 ERA and a 1.16 WHIP. Fedde has done some of his best work at home, where he has a 2.66 ERA and has held opponents to a .221 BA.

Chicago White Sox vs Chicago Cubs Form

Table

Teams Pts P W L
7 Chicago Cubs
0.542 83 45 38
8 Chicago White Sox
0.531 81 43 38

Chicago White Sox and Chicago Cubs Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

May 15, 2026 - MLB

Chicago White Sox
5 :  10
Chicago Cubs

May 14, 2026 - MLB

Chicago White Sox
6 :  2
Kansas City Royals

May 13, 2026 - MLB

Chicago White Sox
6 :  5
Kansas City Royals

May 12, 2026 - MLB

Chicago White Sox
6 :  5
Kansas City Royals

May 10, 2026 - MLB

Chicago White Sox
2 :  1
Seattle Mariners
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

May 15, 2026 - MLB

Chicago White Sox
5 :  10
Chicago Cubs

May 14, 2026 - MLB

Chicago White Sox
6 :  2
Kansas City Royals

May 13, 2026 - MLB

Chicago White Sox
6 :  5
Kansas City Royals

May 12, 2026 - MLB

Chicago White Sox
6 :  5
Kansas City Royals

May 10, 2026 - MLB

Chicago White Sox
2 :  1
Seattle Mariners
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 6, 2026 - MLB

Los Angeles Angels
8 :  2
Chicago White Sox

May 5, 2026 - MLB

Los Angeles Angels
4 :  3
Chicago White Sox

May 4, 2026 - MLB

Los Angeles Angels
0 :  6
Chicago White Sox

May 3, 2026 - MLB

San Diego Padres
4 :  3
Chicago White Sox

May 2, 2026 - MLB

San Diego Padres
0 :  4
Chicago White Sox

May 1, 2026 - MLB

San Diego Padres
2 :  8
Chicago White Sox
Chicago Cubs
Chicago Cubs Latest matches
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

May 15, 2026 - MLB

Chicago White Sox
5 :  10
Chicago Cubs

May 14, 2026 - MLB

Atlanta Braves
0 :  2
Chicago Cubs

May 13, 2026 - MLB

Atlanta Braves
4 :  1
Chicago Cubs

May 12, 2026 - MLB

Atlanta Braves
5 :  2
Chicago Cubs

May 10, 2026 - MLB

Texas Rangers
3 :  0
Chicago Cubs
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 7, 2026 - MLB

Chicago Cubs
8 :  3
Cincinnati Reds

May 6, 2026 - MLB

Chicago Cubs
7 :  6
Cincinnati Reds

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Chicago Cubs
8 :  4
Arizona Diamondbacks

May 2, 2026 - MLB

Chicago Cubs
2 :  0
Arizona Diamondbacks
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

May 15, 2026 - MLB

Chicago White Sox
5 :  10
Chicago Cubs

May 14, 2026 - MLB

Atlanta Braves
0 :  2
Chicago Cubs

May 13, 2026 - MLB

Atlanta Braves
4 :  1
Chicago Cubs

May 12, 2026 - MLB

Atlanta Braves
5 :  2
Chicago Cubs

May 10, 2026 - MLB

Texas Rangers
3 :  0
Chicago Cubs

Chicago White Sox against Chicago Cubs : Head to Head (H2H)

Chicago White Sox

67 %

Chicago Cubs

33 %

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

May 15, 2026 - MLB

Chicago White Sox
5 :  10
Chicago Cubs

Mar 13, 2026 - MLB Spring Training

Chicago White Sox
4 :  2
Chicago Cubs

Mar 1, 2026 - MLB Spring Training

Chicago Cubs
1 :  5
Chicago White Sox

Feb 20, 2026 - MLB Spring Training

Chicago Cubs
1 :  8
Chicago White Sox

Jul 27, 2025 - MLB

Chicago White Sox
4 :  5
Chicago Cubs

Chicago White Sox - Chicago Cubs Key Points

  1. The White Sox are 12-10 ATS (run line) at home; the Cubs are 9-13 ATS (run line) on the road.
  2. The OVER is 12-10 for the White Sox at home and 12-9-1 for the Cubs on the road.
  3. Cubs lineup has hit .309 against Fedde in 97 at-bats (30 hits, four home runs).
  4. Betting Public: 62% of total tickets and 61% of the handle are on the OVER.

Our Chicago White Sox vs Chicago Cubs Prediction

Rea has had some solid moments but has been hit hard a lot, too. Fedde hasn’t been hit as hard, but he seldom goes beyond five innings. Both teams hit well in the first two games of this series. Rea has given up six home runs this season, three in his last two starts. Fedde has given up seven in his last three starts and ten this season. Assuming both teams can hit as well in this contest as they did in the first two games, the final score should easily surpass the total.

Our Cubs vs. White Sox Pick: OVER 8.5

Prediction:

 

OVER 8.5

-106
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago White Sox vs Chicago Cubs Picks