Chicago White Sox vs Chicago Cubs Prediction & Picks - MLB
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by Stephen Abiola | in MLB Picks
Chicago White Sox (22-22) and Chicago Cubs (26-19) will clash in Game 2 of this three-game series at Guaranteed Rate Field. The White Sox got off to a slow off to a slow start in this series, losing the opener on Friday night. Miguel Vargas, Colson Montgomerey, and Kelenic hit solo homers for the hosts, although this wasn’t enough to save them from the 5-10 drubbing. The hosts will be keen to control the game early and keep their rivals in check.
Chicago Cubs, on the other side of the grass, will be buzzing with confidence after their massive win in the series opener. Carson Kelly rallied the team in the seventh inning to hit a tiebreaking single before driving in four runs. The Cubs looked lively in offense later in the game and racked up a total of 14 hits. They’ll know that replicating another 15-run performance could be a tall order, although their renewed confidence makes them a tough opponent today.
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Chicago White Sox vs Chicago Cubs Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
7
|
0.542 | 83 | 45 | 38 |
|
8
|
0.531 | 81 | 43 | 38 |
Chicago White Sox and Chicago Cubs Latest Matches
5/6 (83%)
1/6 (17%)
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5/6 (83%)
1/6 (17%)
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3/6 (50%)
3/6 (50%)
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2/6 (33%)
4/6 (67%)
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6/6 (100%)
0/6 (0%)
May 7, 2026 - MLB
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2/6 (33%)
4/6 (67%)
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Chicago White Sox against Chicago Cubs : Head to Head (H2H)
50 %
50 %
May 15, 2026 - MLB
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Chicago White Sox - Chicago Cubs Key Points
- The White Sox scored over 3.5 runs in six of the last seven matches.
- The White Sox scored over 3.5 runs in three of their last five games against the Cubs.
- The White Sox scored over 3.5 runs in six of their last seven home games.
- The White Sox are 5-1 in their last six matches at home.
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Our Chicago White Sox vs Chicago Cubs Prediction
Bookies expect a tight contest, listing both sides at -115 odds. The Cubs have historically gotten results against the White Sox, going 10-4 in their last 14 meetings. They’re one of the most well-balanced teams in the league, coming into this contest with a .247 batting average. However, that will not count much against the White Sox, who have been hitting well at home. They’ll want to play aggressively against Jameson Taillon, who is 2-2 this season with a 3.94 ERA. Davis Martin of the White Sox is the more reliable pitcher, boasting a 5-1 record with a 1.62 ERA. With both sides finding their offensive touch, we expect another thriller with the hosts edging it this time.
Our prediction for Chicago White Sox vs Chicago Cubs: White Sox to score over 3.5 runs.
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