Chicago White Sox vs Chicago Cubs Prediction & Picks - MLB
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by Travis Pulver | in MLB Picks
Baseball fans in the Windy City are in for a treat this weekend with the White Sox and Cubs facing off for a three-game series at Rate Field. First Pitch for Game 1 of this three-game series is tonight at 7:40 p.m. EST with coverage provided by MLB.TV.
The Cubs have owned the series the last few seasons, winning 12 of the 14 games played between them and six of seven at Rate Field. The White Sox have not won the season series since 2022 (3-1) and have not won a series at home against the Cubs since 2021 (2-1).
Sean Burke is scheduled to get the start for the home team, the White Sox. Burke has a 2-3 record in eight starts with a 3.68 ERA and a 1.09 WHIP. However, while he has held opposing batters to a .214 OBA at home in five appearances (three starts), he has a 4.18 ERA and has yet to record a win at home.
Edward Cabrera is scheduled to start for the Cubs. Cabrera has a 3-1 record in eight starts with a 3.88 ERA and a 1.32 WHIP. In three road starts, he has a 1-1 record with a 4.41 ERA and has held opposing batters to a .237 OBA.
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Chicago White Sox vs Chicago Cubs Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
5
|
0.58 | 119 | 69 | 50 |
|
10
|
0.521 | 117 | 61 | 56 |
Chicago White Sox and Chicago Cubs Latest Matches
5/6 (83%)
1/6 (17%)
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5/6 (83%)
1/6 (17%)
May 14, 2026 - MLB
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3/6 (50%)
3/6 (50%)
May 6, 2026 - MLB
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May 1, 2026 - MLB
2/6 (33%)
4/6 (67%)
May 14, 2026 - MLB
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6/6 (100%)
0/6 (0%)
May 7, 2026 - MLB
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2/6 (33%)
4/6 (67%)
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Chicago White Sox against Chicago Cubs : Head to Head (H2H)
67 %
33 %
Mar 13, 2026 - MLB Spring Training
Mar 1, 2026 - MLB Spring Training
Feb 20, 2026 - MLB Spring Training
Jul 27, 2025 - MLB
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Chicago White Sox - Chicago Cubs Key Points
- The all-time series between the Cubs and White Sox is tied at 79-79.
- The Cubs are 20-24 ATS (run line); the White Sox are 24-18.
- The OVER is 24-19-1 for the Cubs and 24-19 for the White Sox.
- Betting Public: 27% of moneyline tickets and 36% of the handle are on the White Sox.
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Our Chicago White Sox vs Chicago Cubs Prediction
The Cubbies are off to a better start this season with a 28-16 record heading into this game, but the White Sox haven’t been too bad at a game above .500 (22-21). But what’s more important is how each team has been playing. The White Sox have won five in a row at home, outscoring opponents 26-14 while hitting .263. As for the Cubs, they’ve lost four of their last five and were outscored 18-5. It is possible the Cubs wake up against their crosstown rival, but I’ve got to go with the hot hand and plus money odds on this one.
Our Cubs vs. White Sox Pick: White Sox ML
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
