Arizona Diamondbacks vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

Arizona Diamondbacks
8/26/26 15:40
Chicago Cubs

Prediction:

 

UNDER 8.5

−111
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 by Travis Pulver | in MLB Picks

The Arizona Diamondbacks (69-63, 38-29 Home) are scheduled to host the Chicago Cubs (76-56, 38-29 Away) at Chase Field. Fans can follow the action via ESPN Unlimited when the game gets underway at 3:40 p.m. EST.

Chicago dominated the series opener on Monday, shutting the D-backs out 7-0. When this post was written, the Cubbies held a 4-0 lead heading into the eighth.

Matthew Boyd is scheduled to get the start for the Cubs on Wednesday. Boyd is 8-2 this season in 16 starts with a 4.15 ERA, a 1.24 WHIP, and teams have been hitting .246 against him. He has yet to lose a game on the road, going 3-0 in eight starts with a 3.0 ERA and a .236 OBA.

Arizona is scheduled to go with Eduardo Rodriguez. Rodriguez is 13-4 in 26 starts with a 2.61 ERA, a 1.21 WHIP, and teams have hit .237 against him this season. When pitching at home, he has gone 7-3 in 14 starts with a 2.67 ERA and a .226 OBA. While he pitched 5 2/3 shutout innings in his last start (Aug. 21), he gave up nine across his previous three. He has recorded three straight wins.

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Arizona Diamondbacks vs Chicago Cubs Form

Table

Teams Pts P W L
7 Chicago Cubs
0.549 162 89 73
10 Arizona Diamondbacks
0.531 162 86 76

Arizona Diamondbacks and Chicago Cubs Latest Matches

Arizona Diamondbacks
Arizona Diamondbacks Latest matches
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 24, 2026 - MLB

Arizona Diamondbacks
0 :  7
Chicago Cubs

Aug 23, 2026 - MLB

Arizona Diamondbacks
5 :  3
Cincinnati Reds

Aug 22, 2026 - MLB

Arizona Diamondbacks
5 :  11
Cincinnati Reds

Aug 21, 2026 - MLB

Arizona Diamondbacks
9 :  0
Cincinnati Reds

Aug 19, 2026 - MLB

Boston Red Sox
6 :  7
Arizona Diamondbacks

Aug 18, 2026 - MLB

Boston Red Sox
9 :  4
Arizona Diamondbacks
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 24, 2026 - MLB

Arizona Diamondbacks
0 :  7
Chicago Cubs

Aug 23, 2026 - MLB

Arizona Diamondbacks
5 :  3
Cincinnati Reds

Aug 22, 2026 - MLB

Arizona Diamondbacks
5 :  11
Cincinnati Reds

Aug 21, 2026 - MLB

Arizona Diamondbacks
9 :  0
Cincinnati Reds

Aug 12, 2026 - MLB

Arizona Diamondbacks
4 :  6
Colorado Rockies

Aug 11, 2026 - MLB

Arizona Diamondbacks
2 :  3
Colorado Rockies
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 19, 2026 - MLB

Boston Red Sox
6 :  7
Arizona Diamondbacks

Aug 18, 2026 - MLB

Boston Red Sox
9 :  4
Arizona Diamondbacks

Aug 17, 2026 - MLB

Boston Red Sox
11 :  1
Arizona Diamondbacks

Aug 16, 2026 - MLB

Atlanta Braves
5 :  3
Arizona Diamondbacks

Aug 15, 2026 - MLB

Atlanta Braves
3 :  10
Arizona Diamondbacks

Aug 14, 2026 - MLB

Atlanta Braves
0 :  2
Arizona Diamondbacks
Chicago Cubs
Chicago Cubs Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 24, 2026 - MLB

Arizona Diamondbacks
0 :  7
Chicago Cubs

Aug 23, 2026 - MLB

Seattle Mariners
2 :  19
Chicago Cubs

Aug 22, 2026 - MLB

Seattle Mariners
5 :  4
Chicago Cubs

Aug 21, 2026 - MLB

Seattle Mariners
6 :  5
Chicago Cubs

Aug 19, 2026 - MLB

Chicago Cubs
0 :  3
Chicago White Sox

Aug 18, 2026 - MLB

Chicago Cubs
4 :  3
Chicago White Sox
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 19, 2026 - MLB

Chicago Cubs
0 :  3
Chicago White Sox

Aug 18, 2026 - MLB

Chicago Cubs
4 :  3
Chicago White Sox

Aug 17, 2026 - MLB

Chicago Cubs
7 :  5
Chicago White Sox

Aug 16, 2026 - MLB

Chicago Cubs
4 :  11
St. Louis Cardinals

Aug 15, 2026 - MLB

Chicago Cubs
4 :  8
St. Louis Cardinals

Aug 14, 2026 - MLB

Chicago Cubs
3 :  0
St. Louis Cardinals
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 24, 2026 - MLB

Arizona Diamondbacks
0 :  7
Chicago Cubs

Aug 23, 2026 - MLB

Seattle Mariners
2 :  19
Chicago Cubs

Aug 22, 2026 - MLB

Seattle Mariners
5 :  4
Chicago Cubs

Aug 21, 2026 - MLB

Seattle Mariners
6 :  5
Chicago Cubs

Aug 13, 2026 - MLB

Washington Nationals
7 :  0
Chicago Cubs

Aug 12, 2026 - MLB

Washington Nationals
6 :  12
Chicago Cubs

Arizona Diamondbacks against Chicago Cubs : Head to Head (H2H)

Arizona Diamondbacks

17 %

Chicago Cubs

83 %

Aug 24, 2026 - MLB

Arizona Diamondbacks
0 :  7
Chicago Cubs

May 3, 2026 - MLB

Chicago Cubs
8 :  4
Arizona Diamondbacks

May 2, 2026 - MLB

Chicago Cubs
2 :  0
Arizona Diamondbacks

May 1, 2026 - MLB

Chicago Cubs
6 :  5
Arizona Diamondbacks

Mar 18, 2026 - MLB Spring Training

Arizona Diamondbacks
16 :  8
Chicago Cubs

Mar 5, 2026 - MLB Spring Training

Chicago Cubs
8 :  1
Arizona Diamondbacks
Arizona Diamondbacks vs Chicago Cubs Picks

Arizona Diamondbacks - Chicago Cubs Key Points

  1. Over the last three seasons, the Cubs have beaten the D-backs in 11 of 17 games.
  2. Arizona is 36-29 ATS (run line) at home this season; Chicago is 37-30 ATS (run line) on the road.
  3. The OVER is 27-34-4 for the D-backs at home and 37-28-2  for the Cubbies on the road.
  4. Betting Public: 40% of total tickets and 41% of the handle are on the OVER.

Our Arizona Diamondbacks vs Chicago Cubs Prediction

Both teams have been hitting around .260 over the last week, but the Cubs have certainly been getting the better of Arizona’s pitchers in this series. Rodriguez gives the D-backs a definite advantage on the mound, but Boyd is not too bad either, especially when he pitches on the road. I’d lean towards Arizona to win outright as Rodriguez gives them a definite edge. But I think both starting pitchers will have solid games, keeping the final score relatively low.

Our Chicago vs. Arizona Pick: UNDER 8.5

Prediction:

 

UNDER 8.5

−111
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.