San Francisco 49ers vs Carolina Panthers Prediction & Picks - NFL

USA - NFL

San Francisco 49ers
11/24/25 20:15
Carolina Panthers

Prediction:

 

Carolina Panthers +7.5 Alternate Spread

-131
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 by Matt Lowrimore | in NFL Picks

Week 12 of the NFL will conclude on Monday night with a game that will see the San Francisco 49ers take on the Carolina Panthers take on the Indianapolis Colts. Let’s take a look at the match statistics and predictions for this game between the 49ers and the Panthers.

Carolina enters this game with a record of 6-5, having most recently beaten the Atlanta Falcons in Week 11 by a score of 30-27. The Panthers’ offense had a total of 486 yards, while its defense allowed 348 yards. Quarterback Bryce Young threw for 448 yards and three touchdowns, while running back Rico Dowdle led the team in rushing with 45 yards.

As for San Francisco, they enter this game with a record of 7-4, having most recently beaten the Arizona Cardinals in Week 11 by a score of 41-22. The 49ers’ offense had a total of 281 yards, while its defense allowed 488 yards. Quarterback Brock Purdy threw for 200 yards and three touchdowns, while running back Christian McCaffrey led the team in rushing with 81 yards and three total touchdowns.

San Francisco 49ers vs Carolina Panthers Form

Table

Teams Pts P W L
7 San Francisco 49ers
0.706 17 12 5
18 Carolina Panthers
0.471 17 8 9

San Francisco 49ers and Carolina Panthers Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Nov 9, 2025 - NFL

San Francisco 49ers
26 :  42
Los Angeles Rams

Nov 2, 2025 - NFL

New York Giants
24 :  34
San Francisco 49ers

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Oct 19, 2025 - NFL

San Francisco 49ers
20 :  10
Atlanta Falcons

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 9, 2025 - NFL

San Francisco 49ers
26 :  42
Los Angeles Rams

Oct 19, 2025 - NFL

San Francisco 49ers
20 :  10
Atlanta Falcons

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Nov 2, 2025 - NFL

New York Giants
24 :  34
San Francisco 49ers

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers

Oct 2, 2025 - NFL

Los Angeles Rams
23 :  26
San Francisco 49ers

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers
Carolina Panthers
Carolina Panthers Latest matches
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 16, 2025 - NFL

Atlanta Falcons
27 :  30
Carolina Panthers

Nov 9, 2025 - NFL

Carolina Panthers
7 :  17
New Orleans Saints

Nov 2, 2025 - NFL

Green Bay Packers
13 :  16
Carolina Panthers

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 19, 2025 - NFL

New York Jets
6 :  13
Carolina Panthers

Oct 12, 2025 - NFL

Carolina Panthers
30 :  27
Dallas Cowboys
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 9, 2025 - NFL

Carolina Panthers
7 :  17
New Orleans Saints

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 12, 2025 - NFL

Carolina Panthers
30 :  27
Dallas Cowboys

Oct 5, 2025 - NFL

Carolina Panthers
27 :  24
Miami Dolphins

Sep 21, 2025 - NFL

Carolina Panthers
30 :  0
Atlanta Falcons

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 16, 2025 - NFL

Atlanta Falcons
27 :  30
Carolina Panthers

Nov 2, 2025 - NFL

Green Bay Packers
13 :  16
Carolina Panthers

Oct 19, 2025 - NFL

New York Jets
6 :  13
Carolina Panthers

Sep 28, 2025 - NFL

New England Patriots
42 :  13
Carolina Panthers

Sep 14, 2025 - NFL

Arizona Cardinals
27 :  22
Carolina Panthers

Sep 7, 2025 - NFL

Jacksonville Jaguars
26 :  10
Carolina Panthers

San Francisco 49ers - Carolina Panthers Key Points

  1. The 49ers are averaging 23.7 points per game
  2. The 49ers are allowing 22.9 points per game
  3. The Panthers are averaging 18.8 points per game
  4. The Panthers are allowing 22.6 points per game

Our San Francisco 49ers vs Carolina Panthers Prediction

The 49ers are the touchdown favorite in this game; however, the Panthers could be the best betting option. Carolina is coming off one of their best games offensively last week, where their quarterback, Bryce Young, had a career-high in passing yards.

The 49ers, on the other hand, have won three straight games, but are now facing a Panthers team that has slowly been improving. San Francisco has a lethal rushing attack with McCaffrey; however, they can sometimes be inconsistent in the passing game with Brock Purdy at quarterback. For that reason, our San Francisco 49ers vs Carolina Panthers prediction is: Carolina Panthers +7.5 Alternate Spread.

Prediction:

 

Carolina Panthers +7.5 Alternate Spread

-131
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

San Francisco 49ers vs Carolina Panthers Picks