New England Patriots vs Buffalo Bills Prediction & Picks - NFL

USA - NFL

New England Patriots
12/14/25 13:00
Buffalo Bills

Prediction:

 

Over 248.5.

-110
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 by Carlos Zabala | in NFL Picks

The Bills managed to defeat the Bengals in a thrilling game last week, securing their ninth win of the season. The Bills secured their ninth win of the season by defeating the Bengals by a score of 39-34 in a snowy Highmark Stadium; Buffalo secured the victory in the final moments with a play that garnered significant attention. Brentford, in an impractical fashion, intercepted Burrow's soft pass and executed a 63-yard pick-6. Josh Allen had an outstanding day, throwing three touchdown passes for the Bills and running for another for himself.

In the NFL Week 15 betting odds, there's no matchup closer than the Bills-Patriots. The 11-2 Pats are slight underdogs at Gillette Stadium; a win for New England would clinch their first division title of the decade.

The formidable Patriots have won each of their last 10 games, had a bye last week, and then defeated the Giants 33-15 in Week 13.

Drake Maye, the New England quarterback, continues to have an epic season. Against the Giants, he completed 24 of 31 passes for 282 yards and two touchdowns.

New England Patriots vs Buffalo Bills Form

Table

Teams Pts P W L
3 New England Patriots
0.824 17 14 3
8 Buffalo Bills
0.706 17 12 5

New England Patriots and Buffalo Bills Latest Matches

New England Patriots
New England Patriots Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Dec 1, 2025 - NFL

New England Patriots
33 :  15
New York Giants

Nov 23, 2025 - NFL

Cincinnati Bengals
20 :  26
New England Patriots

Nov 13, 2025 - NFL

New England Patriots
27 :  14
New York Jets

Nov 9, 2025 - NFL

Tampa Bay Buccaneers
23 :  28
New England Patriots

Nov 2, 2025 - NFL

New England Patriots
24 :  23
Atlanta Falcons

Oct 26, 2025 - NFL

New England Patriots
32 :  13
Cleveland Browns
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 1, 2025 - NFL

New England Patriots
33 :  15
New York Giants

Nov 13, 2025 - NFL

New England Patriots
27 :  14
New York Jets

Nov 2, 2025 - NFL

New England Patriots
24 :  23
Atlanta Falcons

Oct 26, 2025 - NFL

New England Patriots
32 :  13
Cleveland Browns

Sep 28, 2025 - NFL

New England Patriots
42 :  13
Carolina Panthers

Sep 21, 2025 - NFL

New England Patriots
14 :  21
Pittsburgh Steelers
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 23, 2025 - NFL

Cincinnati Bengals
20 :  26
New England Patriots

Nov 9, 2025 - NFL

Tampa Bay Buccaneers
23 :  28
New England Patriots

Oct 19, 2025 - NFL

Tennessee Titans
13 :  31
New England Patriots

Oct 12, 2025 - NFL

New Orleans Saints
19 :  25
New England Patriots

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 14, 2025 - NFL

Miami Dolphins
27 :  33
New England Patriots
Buffalo Bills
Buffalo Bills Latest matches
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 7, 2025 - NFL

Buffalo Bills
39 :  34
Cincinnati Bengals

Nov 30, 2025 - NFL

Pittsburgh Steelers
7 :  26
Buffalo Bills

Nov 20, 2025 - NFL

Houston Texans
23 :  19
Buffalo Bills

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 9, 2025 - NFL

Miami Dolphins
30 :  13
Buffalo Bills

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 7, 2025 - NFL

Buffalo Bills
39 :  34
Cincinnati Bengals

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 28, 2025 - NFL

Buffalo Bills
31 :  19
New Orleans Saints

Sep 18, 2025 - NFL

Buffalo Bills
31 :  21
Miami Dolphins
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 30, 2025 - NFL

Pittsburgh Steelers
7 :  26
Buffalo Bills

Nov 20, 2025 - NFL

Houston Texans
23 :  19
Buffalo Bills

Nov 9, 2025 - NFL

Miami Dolphins
30 :  13
Buffalo Bills

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Sep 14, 2025 - NFL

New York Jets
10 :  30
Buffalo Bills

New England Patriots against Buffalo Bills : Head to Head (H2H)

New England Patriots

60 %

Buffalo Bills

40 %

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Jan 5, 2025 - NFL

New England Patriots
23 :  16
Buffalo Bills

Dec 22, 2024 - NFL

Buffalo Bills
24 :  21
New England Patriots

Dec 31, 2023 - NFL

Buffalo Bills
27 :  21
New England Patriots

Oct 22, 2023 - NFL

New England Patriots
29 :  25
Buffalo Bills

New England Patriots - Buffalo Bills Key Points

  1. The Bills are second in the NFL in total yards with 399.1
  2. The Bills lead the NFL in rushing yards per game with 157.8
  3. The Patriots have the sixth-best defense in terms of total yards allowed per game
  4. Buffalo are 3-3 on the road this season

Our New England Patriots vs Buffalo Bills Prediction

Maye's elite season has Pats fans buzzing. Comparisons to Brady are inevitable, especially since he has completed over 70% of his passes this season. He is on track to surpass the franchise record Brady set in 2007 with 68.9%.

Despite interceptions 10 times this season, Josh Allen is enjoying a very respectable season with the Bills. Therefore, a high-scoring match seems likely.

Our predictions for Bills vs Patriots are: Over 248.5.

Prediction:

 

Over 248.5.

-110
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

New England Patriots vs Buffalo Bills Picks