Buffalo Bills vs Houston Texans Prediction & Picks - NFL

USA - NFL

Buffalo Bills
11/20/25 20:15
Houston Texans

Prediction:

 

UNDER 43.5

-105
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 by Travis Pulver in NFL Picks

The Houston Texans will try to push their record above .500 for the first time this season when they host the Buffalo Bills at NRG Stadium on Thursday Night Football. Kickoff for this AFC battle is scheduled for 8:15 p.m. EST on Prime Video.

Houston enters this game on a two-game winning streak, having won three of its last four games. Thursday will be the third start for backup Davis Mills, filling in for C.J. Stroud, who had to leave the loss to Denver a few weeks ago early because of a concussion. Before Stroud’s concussion, the defense (which happens to be the No. 1 unit in the league) led the way for the Texans, making it possible to win a few games while struggling to get the offense on track.

Josh Allen and the Bills snapped back last week following an embarrassing loss to the Dolphins the week before with a 44-32 win over Tampa Bay. Allen led the way with 317 yards passing and three touchdowns, along with a pair of interceptions. He also added three scores on the ground. But the Bucs defense did shut down James Cook, allowing just 40 rushing yards.

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Buffalo Bills vs Houston Texans Form

Table

Teams % P W D L
6
Buffalo Bills
Buffalo Bills
0.7 10 7 0 3
17
Houston Texans
Houston Texans
0.5 10 5 0 5

Buffalo Bills and Houston Texans Latest Matches

Buffalo Bills
Buffalo Bills Latest matches
L L W W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 16, 2025 - NFL

Tampa Bay Buccaneers
32 :  44
Buffalo Bills

Nov 9, 2025 - NFL

Buffalo Bills
13 :  30
Miami Dolphins

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 16, 2025 - NFL

Tampa Bay Buccaneers
32 :  44
Buffalo Bills

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 28, 2025 - NFL

New Orleans Saints
19 :  31
Buffalo Bills

Sep 18, 2025 - NFL

Miami Dolphins
21 :  31
Buffalo Bills

Sep 7, 2025 - NFL

Baltimore Ravens
40 :  41
Buffalo Bills
L L W L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 9, 2025 - NFL

Buffalo Bills
13 :  30
Miami Dolphins

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Sep 14, 2025 - NFL

Buffalo Bills
30 :  10
New York Jets

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots
Houston Texans
Houston Texans Latest matches
W L W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 16, 2025 - NFL

Houston Texans
16 :  13
Tennessee Titans

Nov 9, 2025 - NFL

Jacksonville Jaguars
29 :  36
Houston Texans

Nov 2, 2025 - NFL

Denver Broncos
18 :  15
Houston Texans

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Oct 20, 2025 - NFL

Houston Texans
19 :  27
Seattle Seahawks

Oct 5, 2025 - NFL

Houston Texans
44 :  10
Baltimore Ravens
W L W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 9, 2025 - NFL

Jacksonville Jaguars
29 :  36
Houston Texans

Nov 2, 2025 - NFL

Denver Broncos
18 :  15
Houston Texans

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 15, 2025 - NFL

Tampa Bay Buccaneers
20 :  19
Houston Texans

Jan 11, 2025 - NFL

Los Angeles Chargers
12 :  32
Houston Texans
L L L W L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 16, 2025 - NFL

Houston Texans
16 :  13
Tennessee Titans

Oct 20, 2025 - NFL

Houston Texans
19 :  27
Seattle Seahawks

Oct 5, 2025 - NFL

Houston Texans
44 :  10
Baltimore Ravens

Sep 21, 2025 - NFL

Houston Texans
10 :  17
Jacksonville Jaguars

Sep 7, 2025 - NFL

Houston Texans
9 :  14
Los Angeles Rams

Jan 18, 2025 - NFL

Houston Texans
14 :  23
Kansas City Chiefs

Buffalo Bills against Houston Texans : Head to Head (H2H)

Buffalo Bills

0 %

Draw

0 %

Houston Texans

100 %

Oct 6, 2024 - NFL

Buffalo Bills
20 :  23
Houston Texans

Jan 4, 2020 - NFL

Buffalo Bills
19 :  22
Houston Texans

Buffalo Bills - Houston Texans Key Points

  1. Houston holds the all-time series lead vs. Buffalo, 7-5; the Texans won last year’s meeting, 23-20.
  2. Buffalo has lost the last five meetings in Houston; the last time Buffalo won a road game against the Texans was in the 2006 season.
  3. The OVER is 3-6-1 for Houston and 5-5 for Buffalo. The OVER is 1-3 for Buffalo on the road.
  4. Betting Public: 50% of TOTAL tickets and 67% of the handle are on the UNDER.
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Our Buffalo Bills vs Houston Texans Prediction

With how poorly Houston has played on offense for much of the season, it is hard to imagine them actually beating an offensive powerhouse like Buffalo—but they could. If the defense can keep Josh Allen in check and James Cook from heating up, maybe Davis Mills will have enough time to get the offense on track and score enough points to win. But whether they win or not, one outcome seems likely: a low score.

Our Bills vs. Texans Pick: UNDER 43.5

Prediction:

 

UNDER 43.5

-105
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Buffalo Bills vs Houston Texans Picks