St. Louis Cardinals vs Boston Red Sox Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
4/10/26 20:15
Boston Red Sox

Prediction:

 

Cardinals ML

+122
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 by Travis Pulver | in MLB Picks

The Boston Red Sox (4-8, 1-5 Away) will try to keep the good times rolling today as they head out onto the road for a three-game series with the Cardinals (7-5, 4-2 Home) in St. Louis. Fans can follow the action tonight on MLB.TV when the game gets underway at Busch Stadium at 8:15 p.m. EST.

Boston began the season with a shutout road win vs. the Reds in Cincinnati, 3-0, but went on to lose the next five in a row, all on the road. Things were not too much better at home, where they were 1-3 before taking the last two of the series vs. Milwaukee. They’ll give the ball to Connelly Early to start the day. He has a 2.89 ERA and ten strikeouts to his name, but has yet to make it past 5 1/3 innings and has walked six, but has yet to give up a home run.

 St Louis is coming home after going 3-3 on a short road trip, but went 3-1 in the last four. Dustin May is set to start the day for the Cardinals, so put any and all  Red Sox into your fantasy lineups. May has a 15.95 ERA after giving up six runs in four innings in his first start and seven runs in his second, which lasted just 3 1/3 innings.

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St. Louis Cardinals vs Boston Red Sox Form

Table

Teams Pts P W L
11 St. Louis Cardinals
0.525 80 42 38
24 Boston Red Sox
0.432 81 35 46

St. Louis Cardinals and Boston Red Sox Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 8, 2026 - MLB

Washington Nationals
1 :  6
St. Louis Cardinals

Apr 7, 2026 - MLB

Washington Nationals
6 :  7
St. Louis Cardinals

Apr 6, 2026 - MLB

Washington Nationals
9 :  6
St. Louis Cardinals

Apr 5, 2026 - MLB

Detroit Tigers
3 :  5
St. Louis Cardinals

Apr 4, 2026 - MLB

Detroit Tigers
11 :  6
St. Louis Cardinals

Apr 3, 2026 - MLB

Detroit Tigers
4 :  0
St. Louis Cardinals
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 1, 2026 - MLB

St. Louis Cardinals
2 :  1
New York Mets

Mar 31, 2026 - MLB

St. Louis Cardinals
3 :  0
New York Mets

Mar 30, 2026 - MLB

St. Louis Cardinals
2 :  4
New York Mets

Mar 29, 2026 - MLB

St. Louis Cardinals
7 :  11
Tampa Bay Rays

Mar 28, 2026 - MLB

St. Louis Cardinals
6 :  5
Tampa Bay Rays

Mar 26, 2026 - MLB

St. Louis Cardinals
9 :  7
Tampa Bay Rays
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 8, 2026 - MLB

Washington Nationals
1 :  6
St. Louis Cardinals

Apr 7, 2026 - MLB

Washington Nationals
6 :  7
St. Louis Cardinals

Apr 6, 2026 - MLB

Washington Nationals
9 :  6
St. Louis Cardinals

Apr 5, 2026 - MLB

Detroit Tigers
3 :  5
St. Louis Cardinals

Apr 4, 2026 - MLB

Detroit Tigers
11 :  6
St. Louis Cardinals

Apr 3, 2026 - MLB

Detroit Tigers
4 :  0
St. Louis Cardinals
Boston Red Sox
Boston Red Sox Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 8, 2026 - MLB

Boston Red Sox
5 :  0
Milwaukee Brewers

Apr 7, 2026 - MLB

Boston Red Sox
3 :  2
Milwaukee Brewers

Apr 6, 2026 - MLB

Boston Red Sox
6 :  8
Milwaukee Brewers

Apr 5, 2026 - MLB

Boston Red Sox
6 :  8
San Diego Padres

Apr 4, 2026 - MLB

Boston Red Sox
2 :  3
San Diego Padres

Apr 3, 2026 - MLB

Boston Red Sox
5 :  2
San Diego Padres
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 8, 2026 - MLB

Boston Red Sox
5 :  0
Milwaukee Brewers

Apr 7, 2026 - MLB

Boston Red Sox
3 :  2
Milwaukee Brewers

Apr 6, 2026 - MLB

Boston Red Sox
6 :  8
Milwaukee Brewers

Apr 5, 2026 - MLB

Boston Red Sox
6 :  8
San Diego Padres

Apr 4, 2026 - MLB

Boston Red Sox
2 :  3
San Diego Padres

Apr 3, 2026 - MLB

Boston Red Sox
5 :  2
San Diego Padres
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 1, 2026 - MLB

Houston Astros
6 :  4
Boston Red Sox

Mar 31, 2026 - MLB

Houston Astros
9 :  2
Boston Red Sox

Mar 30, 2026 - MLB

Houston Astros
8 :  1
Boston Red Sox

Mar 29, 2026 - MLB

Cincinnati Reds
3 :  2
Boston Red Sox

Mar 28, 2026 - MLB

Cincinnati Reds
6 :  5
Boston Red Sox

Mar 26, 2026 - MLB

Cincinnati Reds
0 :  3
Boston Red Sox

St. Louis Cardinals against Boston Red Sox : Head to Head (H2H)

St. Louis Cardinals

25 %

Boston Red Sox

75 %

Apr 6, 2025 - MLB

Boston Red Sox
18 :  7
St. Louis Cardinals

Apr 4, 2025 - MLB

Boston Red Sox
13 :  9
St. Louis Cardinals

May 19, 2024 - MLB

St. Louis Cardinals
3 :  11
Boston Red Sox

Mar 12, 2024 - MLB Spring Training

Boston Red Sox
6 :  8
St. Louis Cardinals

St. Louis Cardinals - Boston Red Sox Key Points

  1. Boston leads the all-time series vs. St. Louis, 28-24.
  2. Boston’s lineup has faced Dustin May in 29 at-bats; May did well, holding them to .172.
  3. St. Louis is 6-5 ATS (run line) this season, and Boston is 3-9.
  4. Betting Public: 31% of moneyline tickets and 30% of the handle are on the Cardinals.
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Our St. Louis Cardinals vs Boston Red Sox Prediction

I do not see a good reason why the public is getting behind Boston so much (69% ML tickets and 70% of the handle). Yes, they’ve won their last two, but they were2-8 prior to those wins for a reason. Dustin May has a good history against the few Red Sox players he’s faced, but that’s not enough to overlook his massive ERA. Even if the Boston bullpen dominated once May gets pulled, the Cardinals' lineup could do well enough against May to give St. Louis the cushion it needs to cover.

Our Pick: Boston vs. St. Louis Pick: Cardinals ML

Prediction:

 

Cardinals ML

+122
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St. Louis Cardinals vs Boston Red Sox Picks