Cincinnati Reds vs Boston Red Sox Prediction & Picks - MLB

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Cincinnati Reds
3/28/26 16:10
Boston Red Sox

Prediction:

 

Red Sox ML

-140
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 by Travis Pulver | in MLB Picks

The Cincinnati Reds will try to get on the right side of the scoreboard for the first time this season when they host the Boston Red Sox in Game Two of a three-game series to open up the 2025 MLB season. First Pitch is scheduled for 4:10 p.m. EST with coverage provided by ESPN Unlimited/MLB.TV.

Garrett Crochet got Boston’s season off to a nice start in Game One of the series on Thursday with six shutout innings, giving up three hits and two walks while striking out eight. Cincinnati went with reliever Pierce Johnson to start the day and pulled him one out into the game after giving up two hits and a run.

Boston is going with Sonny Gray to start the day on the mound. Gray went 14-8 in 32 starts for the Cardinals last season with a 4.28 ERA and 1.23 WHIP. Reds hitters have enjoyed some success against him in the past, hitting .278 (25-90) with five home runs.

Cincinnati is going with Brady Singer to start. Singer pitched in 32 games for the Reds last season, his first with the club, going 14-12 with a 4.03 ERA and 1.24 WHIP. In 71 at-bats against him, Red Sox hitters hit .296, with 21 hits but no home runs.

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Cincinnati Reds vs Boston Red Sox Form

Table

Teams Pts P W L
20 Cincinnati Reds
0.481 81 39 42
24 Boston Red Sox
0.432 81 35 46

Cincinnati Reds and Boston Red Sox Latest Matches

Cincinnati Reds
Cincinnati Reds Latest matches
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Mar 26, 2026 - MLB

Cincinnati Reds
0 :  3
Boston Red Sox

Mar 24, 2026 - MLB Spring Training

Milwaukee Brewers
4 :  1
Cincinnati Reds

Mar 23, 2026 - MLB Spring Training

Milwaukee Brewers
9 :  1
Cincinnati Reds

Mar 22, 2026 - MLB Spring Training

Cleveland Guardians
8 :  2
Cincinnati Reds

Mar 21, 2026 - MLB Spring Training

Cincinnati Reds
11 :  7
Chicago White Sox

Mar 20, 2026 - MLB Spring Training

Chicago Cubs
6 :  8
Cincinnati Reds
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 26, 2026 - MLB

Cincinnati Reds
0 :  3
Boston Red Sox

Mar 21, 2026 - MLB Spring Training

Cincinnati Reds
11 :  7
Chicago White Sox

Mar 18, 2026 - MLB Spring Training

Cincinnati Reds
6 :  8
Colorado Rockies

Mar 17, 2026 - MLB Spring Training

Cincinnati Reds
6 :  8
Cleveland Guardians

Mar 14, 2026 - MLB Spring Training

Cincinnati Reds
4 :  3
Texas Rangers

Mar 13, 2026 - MLB Spring Training

Cincinnati Reds
1 :  0
San Francisco Giants
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Mar 24, 2026 - MLB Spring Training

Milwaukee Brewers
4 :  1
Cincinnati Reds

Mar 23, 2026 - MLB Spring Training

Milwaukee Brewers
9 :  1
Cincinnati Reds

Mar 22, 2026 - MLB Spring Training

Cleveland Guardians
8 :  2
Cincinnati Reds

Mar 20, 2026 - MLB Spring Training

Chicago Cubs
6 :  8
Cincinnati Reds

Mar 18, 2026 - MLB Spring Training

Los Angeles Angels
7 :  4
Cincinnati Reds

Mar 16, 2026 - MLB Spring Training

Arizona Diamondbacks
11 :  6
Cincinnati Reds
Boston Red Sox
Boston Red Sox Latest matches
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Mar 26, 2026 - MLB

Cincinnati Reds
0 :  3
Boston Red Sox

Mar 24, 2026 - MLB Spring Training

Minnesota Twins
15 :  6
Boston Red Sox

Mar 23, 2026 - MLB Spring Training

Boston Red Sox
6 :  9
Minnesota Twins

Mar 22, 2026 - MLB Spring Training

Pittsburgh Pirates
3 :  6
Boston Red Sox

Mar 21, 2026 - MLB Spring Training

Boston Red Sox
1 :  6
Atlanta Braves

Mar 20, 2026 - MLB Spring Training

Tampa Bay Rays
2 :  0
Boston Red Sox
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 23, 2026 - MLB Spring Training

Boston Red Sox
6 :  9
Minnesota Twins

Mar 21, 2026 - MLB Spring Training

Boston Red Sox
1 :  6
Atlanta Braves

Mar 19, 2026 - MLB Spring Training

Boston Red Sox
4 :  2
Minnesota Twins

Mar 17, 2026 - MLB Spring Training

Boston Red Sox
4 :  3
Atlanta Braves

Mar 15, 2026 - MLB Spring Training

Boston Red Sox
7 :  2
Minnesota Twins

Mar 13, 2026 - MLB Spring Training

Boston Red Sox
7 :  6
Tampa Bay Rays
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Mar 26, 2026 - MLB

Cincinnati Reds
0 :  3
Boston Red Sox

Mar 24, 2026 - MLB Spring Training

Minnesota Twins
15 :  6
Boston Red Sox

Mar 22, 2026 - MLB Spring Training

Pittsburgh Pirates
3 :  6
Boston Red Sox

Mar 20, 2026 - MLB Spring Training

Tampa Bay Rays
2 :  0
Boston Red Sox

Mar 18, 2026 - MLB Spring Training

New York Yankees
1 :  0
Boston Red Sox

Mar 14, 2026 - MLB Spring Training

Atlanta Braves
10 :  1
Boston Red Sox

Cincinnati Reds against Boston Red Sox : Head to Head (H2H)

Cincinnati Reds

50 %

Boston Red Sox

50 %

Mar 26, 2026 - MLB

Cincinnati Reds
0 :  3
Boston Red Sox

Jul 2, 2025 - MLB

Boston Red Sox
4 :  8
Cincinnati Reds

Jul 1, 2025 - MLB

Boston Red Sox
5 :  3
Cincinnati Reds

Jun 30, 2025 - MLB

Boston Red Sox
13 :  6
Cincinnati Reds

Jun 21, 2024 - MLB

Cincinnati Reds
5 :  2
Boston Red Sox

May 30, 2023 - MLB

Boston Red Sox
8 :  9
Cincinnati Reds

Cincinnati Reds - Boston Red Sox Key Points

  1. Boston leads the all-time series vs. Cincinnati, 23-11.
  2. Boston went 41-40 in road games last season; Cincinnati went 45-36 at home.
  3. Cincinnati went 1-7 at the plate with runners in scoring position in the opener.
  4. Betting Public: 82% of moneyline tickets and 90% of the handle are on the Red Sox.
Up to $250 to bet on Cincinnati Reds - Boston Red Sox! 

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Our Cincinnati Reds vs Boston Red Sox Prediction

It is not uncommon for hitters to need a little time to find their rhythm once the season gets underway. Cincinnati certainly didn’t have any yesterday, and it is doubtful they will find it today against Gray. At the same time, Singer is a solid pitcher as well. He’ll give the Reds a better start to the day, but the end result will likely be more of the same.

Our Boston vs. Cincinnati Pick: Red Sox ML

Prediction:

 

Red Sox ML

-140
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Cincinnati Reds vs Boston Red Sox Picks