New York Yankees vs Baltimore Orioles Prediction & Picks - MLB

Prediction published on 9/27/25, 9:20 AM  by Lou Aguila | Modified on 9/29/25 at 5:07 AM in MLB Picks

The New York Yankees will try to earn their fourth consecutive head-to-head win over the Baltimore Orioles in Saturday’s Game 2 at Yankee Stadium.

The Yankees are heavy favorites at -235 moneyline and also listed at -114 on a -1.5 run line.

Current Form:

The Yankees (92-68) blew out the Orioles 8-1 in Friday’s series opener to keep in step with the Toronto Blue Jays (92-68) with two games left on the schedule. New York has gone 9-1 in their last 10 games, averaging almost seven runs a game (6.9 runs per game) while commanding a 2.70 ERA.

The Orioles (75-85) are 2-3 in their last five games and have lost six of their previous seven meetings with the Yankees. After surrendering 8 runs against the Yankees on Friday, Baltimore’s ERA over the last five games has jumped to 4.60. Offense continues to be mediocre as they average only 3.8 runs per game on a .191 BA in this five-game stretch.

Pitchers Matchup:

Orioles RHP Tomoyuki Sugano (10-9, 4.54 ERA) vs. Yankees RHP Cam Schlitter (3-3, 3.27 ERA).