New York Yankees vs Baltimore Orioles Prediction & Picks - MLB

Prediction published on 6/21/25, 9:15 AM  by Carlos Zabala | Modified on 7/24/25 at 10:48 PM in MLB Picks

With a +283 underdog, the Orioles won Game 1 of the series against the Yankees in Boston, so the series between last and first in the AL East will be 3 games to 1 in 2025.

With the Yankees opening the game in the midst of a Cy Young Award-winning season, bookmakers set the Yankees as -320 favorites in the betting, having cut their losing streak to six by winning the series finale against the Angels. Although the Yankees had 10 hits in the new loss to the O's, Goldschmidt went 0-for-4, as did Grisham, batting leadoff and second in the order. But none of them are as worrisome as Volpe, who went 0-for-4 with two strikeouts. His AVG is back near 230, and he's starting to wear thin even among die-hard Yankees fans.

Meanwhile, the Orioles, who have been struggling with their starting pitching, are enjoying the best form of their 2025 season, winning seven of their last 10 games. Eflin for Baltimore and Schmidt for the Yankees in Saturday's pitching duel.