Minnesota Twins vs Baltimore Orioles Prediction & Picks - MLB

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Minnesota Twins
5/6/25 19:40
Baltimore Orioles

Prediction:

 

Minnesota Twins win both halves

-162
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 by Erik Gibbs in MLB Picks

The Baltimore Orioles and Minnesota Twins open their first head-to-head series of the season Tuesday night, with both teams entering on contrasting notes. After a day off Monday, they’ll kick off a three-game set in Minneapolis, where the Twins return home looking to build on recent momentum, while the Orioles try to regroup from a disappointing weekend.

Baltimore dropped two of three at home to the Kansas City Royals, a result that stung in the ultra-competitive AL East. The division is stacked this year, and the Orioles have fallen into last place, trailing the first-place Yankees by 5.5 games and the fourth-place Blue Jays by 2.5.

Their struggles are especially evident on offense, where the absence of consistent power has been a growing concern. Gunnar Henderson, last year’s standout rookie, has yet to recapture his form, leaving the middle of the order exposed. The Orioles have now lost two straight and look flat heading into this series.

Minnesota Twins vs Baltimore Orioles Form

Table

Teams Pts P W L
24 Baltimore Orioles
0.463 162 75 87
27 Minnesota Twins
0.432 162 70 92

Minnesota Twins and Baltimore Orioles Latest Matches

Minnesota Twins
Minnesota Twins Latest matches
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 4, 2025 - MLB

Boston Red Sox
4 :  5
Minnesota Twins

May 1, 2025 - MLB

Cleveland Guardians
4 :  3
Minnesota Twins

Apr 30, 2025 - MLB

Cleveland Guardians
4 :  2
Minnesota Twins

Apr 29, 2025 - MLB

Cleveland Guardians
2 :  1
Minnesota Twins

Apr 28, 2025 - MLB

Cleveland Guardians
1 :  11
Minnesota Twins

Apr 27, 2025 - MLB

Minnesota Twins
5 :  0
Los Angeles Angels
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 27, 2025 - MLB

Minnesota Twins
5 :  0
Los Angeles Angels

Apr 26, 2025 - MLB

Minnesota Twins
5 :  1
Los Angeles Angels

Apr 24, 2025 - MLB

Minnesota Twins
0 :  3
Chicago White Sox

Apr 23, 2025 - MLB

Minnesota Twins
6 :  3
Chicago White Sox

Apr 22, 2025 - MLB

Minnesota Twins
4 :  2
Chicago White Sox

Apr 16, 2025 - MLB

Minnesota Twins
4 :  3
New York Mets
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 4, 2025 - MLB

Boston Red Sox
4 :  5
Minnesota Twins

May 1, 2025 - MLB

Cleveland Guardians
4 :  3
Minnesota Twins

Apr 30, 2025 - MLB

Cleveland Guardians
4 :  2
Minnesota Twins

Apr 29, 2025 - MLB

Cleveland Guardians
2 :  1
Minnesota Twins

Apr 28, 2025 - MLB

Cleveland Guardians
1 :  11
Minnesota Twins

Apr 20, 2025 - MLB

Atlanta Braves
6 :  2
Minnesota Twins
Baltimore Orioles
Baltimore Orioles Latest matches
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 4, 2025 - MLB

Baltimore Orioles
6 :  11
Kansas City Royals

May 3, 2025 - MLB

Baltimore Orioles
0 :  4
Kansas City Royals

May 2, 2025 - MLB

Baltimore Orioles
3 :  0
Kansas City Royals

Apr 30, 2025 - MLB

Baltimore Orioles
5 :  4
New York Yankees

Apr 29, 2025 - MLB

Baltimore Orioles
3 :  15
New York Yankees

Apr 28, 2025 - MLB

Baltimore Orioles
4 :  3
New York Yankees
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 4, 2025 - MLB

Baltimore Orioles
6 :  11
Kansas City Royals

May 3, 2025 - MLB

Baltimore Orioles
0 :  4
Kansas City Royals

May 2, 2025 - MLB

Baltimore Orioles
3 :  0
Kansas City Royals

Apr 30, 2025 - MLB

Baltimore Orioles
5 :  4
New York Yankees

Apr 29, 2025 - MLB

Baltimore Orioles
3 :  15
New York Yankees

Apr 28, 2025 - MLB

Baltimore Orioles
4 :  3
New York Yankees
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 27, 2025 - MLB

Detroit Tigers
7 :  0
Baltimore Orioles

Apr 26, 2025 - MLB

Detroit Tigers
4 :  3
Baltimore Orioles

Apr 23, 2025 - MLB

Washington Nationals
4 :  3
Baltimore Orioles

Apr 22, 2025 - MLB

Washington Nationals
7 :  0
Baltimore Orioles

Apr 9, 2025 - MLB

Arizona Diamondbacks
9 :  0
Baltimore Orioles

Apr 8, 2025 - MLB

Arizona Diamondbacks
4 :  3
Baltimore Orioles

Minnesota Twins against Baltimore Orioles : Head to Head (H2H)

Minnesota Twins

0 %

Baltimore Orioles

100 %

Sep 29, 2024 - MLB

Minnesota Twins
2 :  6
Baltimore Orioles

Apr 17, 2024 - MLB

Baltimore Orioles
4 :  2
Minnesota Twins

Apr 16, 2024 - MLB

Baltimore Orioles
11 :  3
Minnesota Twins

Apr 15, 2024 - MLB

Baltimore Orioles
7 :  4
Minnesota Twins

Feb 28, 2024 - MLB Spring Training

Minnesota Twins
3 :  12
Baltimore Orioles

Minnesota Twins - Baltimore Orioles Key Points

  1. The Twins are 7-1 in their last 8 home games
  2. The Twins are 9-0 covering the run line in their last 9 Tuesday night games vs. American League teams
  3. The Orioles are 0-8 in their last 8 games at Target Field vs. teams with a losing record
  4. The Orioles are 1-6 covering the run line in their last 7 games vs. teams with a losing record

Our Minnesota Twins vs Baltimore Orioles Prediction

Minnesota comes in with a confidence boost after a gritty series win over the Red Sox at Fenway. Though the Twins lost three of four in Cleveland to start their road trip, they managed to close it with back-to-back strong outings in Boston. Now back at Target Field — where they own a solid 9-6 record — the Twins will look to extend their success. Their road record sits at just 6-14, so getting back home could make a big difference.

The pitching matchup favors Minnesota as well. Pablo López has been one of their most reliable arms this season, posting a 2.45 ERA and looking sharp in most starts. He’ll be opposed by the Orioles’ Cade Povich, who hasn’t shown the same level of consistency and has struggled to find rhythm early in the year.

With Baltimore’s offense not firing and Povich on the mound, this could be a good spot for Minnesota’s lineup to wake up. Our prediction for Minnesota Twins vs. Baltimore Orioles: Twins to win.

Prediction:

 

Minnesota Twins win both halves

-162
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Minnesota Twins vs Baltimore Orioles Picks