Cleveland Guardians vs Baltimore Orioles Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
4/16/26 18:10
Baltimore Orioles

Prediction:

 

Cleveland (-1) to win

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 by Simon Day | in MLB Picks

The Cleveland Guardians and the Baltimore Orioles will both be looking to snap two game losing streaks when they go head-to-head at Progressive Field on Thursday night.

Despite those recent defeats, both sides are currently in second place in their respective divisions, so they look well placed to mount serious playoff bids this season. 

The Guardians' two recent defeats came at the hands of the St. Louis Cardinals. However, Cleveland's overall performance so far this season has been generally solid, so we expect them to get back to winning ways very quickly. 

As for the Orioles, their recent displays have been somewhat more concerning. Starting pitcher Shane Baz has struggled for form, and whilst Taylor Ward and Gunnar Henderson have been solid on offense, Baltimore's overall output has been slightly disappointing. 

Cleveland Guardians vs Baltimore Orioles Form

Table

Teams Pts P W L
8 Cleveland Guardians
0.519 79 41 38
21 Baltimore Orioles
0.475 80 38 42

Cleveland Guardians and Baltimore Orioles Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 15, 2026 - MLB

St. Louis Cardinals
5 :  3
Cleveland Guardians

Apr 14, 2026 - MLB

St. Louis Cardinals
6 :  5
Cleveland Guardians

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Apr 12, 2026 - MLB

Atlanta Braves
13 :  1
Cleveland Guardians

Apr 11, 2026 - MLB

Atlanta Braves
0 :  6
Cleveland Guardians

Apr 10, 2026 - MLB

Atlanta Braves
11 :  5
Cleveland Guardians
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 8, 2026 - MLB

Cleveland Guardians
10 :  2
Kansas City Royals

Apr 7, 2026 - MLB

Cleveland Guardians
2 :  1
Kansas City Royals

Apr 6, 2026 - MLB

Cleveland Guardians
2 :  4
Kansas City Royals

Apr 5, 2026 - MLB

Cleveland Guardians
6 :  5
Chicago Cubs

Apr 5, 2026 - MLB

Cleveland Guardians
0 :  1
Chicago Cubs

Apr 3, 2026 - MLB

Cleveland Guardians
4 :  1
Chicago Cubs
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 15, 2026 - MLB

St. Louis Cardinals
5 :  3
Cleveland Guardians

Apr 14, 2026 - MLB

St. Louis Cardinals
6 :  5
Cleveland Guardians

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Apr 12, 2026 - MLB

Atlanta Braves
13 :  1
Cleveland Guardians

Apr 11, 2026 - MLB

Atlanta Braves
0 :  6
Cleveland Guardians

Apr 10, 2026 - MLB

Atlanta Braves
11 :  5
Cleveland Guardians
Baltimore Orioles
Baltimore Orioles Latest matches
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 15, 2026 - MLB

Baltimore Orioles
5 :  8
Arizona Diamondbacks

Apr 14, 2026 - MLB

Baltimore Orioles
3 :  4
Arizona Diamondbacks

Apr 13, 2026 - MLB

Baltimore Orioles
9 :  7
Arizona Diamondbacks

Apr 12, 2026 - MLB

Baltimore Orioles
6 :  2
San Francisco Giants

Apr 11, 2026 - MLB

Baltimore Orioles
6 :  2
San Francisco Giants

Apr 10, 2026 - MLB

Baltimore Orioles
3 :  6
San Francisco Giants
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 15, 2026 - MLB

Baltimore Orioles
5 :  8
Arizona Diamondbacks

Apr 14, 2026 - MLB

Baltimore Orioles
3 :  4
Arizona Diamondbacks

Apr 13, 2026 - MLB

Baltimore Orioles
9 :  7
Arizona Diamondbacks

Apr 12, 2026 - MLB

Baltimore Orioles
6 :  2
San Francisco Giants

Apr 11, 2026 - MLB

Baltimore Orioles
6 :  2
San Francisco Giants

Apr 10, 2026 - MLB

Baltimore Orioles
3 :  6
San Francisco Giants
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 8, 2026 - MLB

Chicago White Sox
3 :  5
Baltimore Orioles

Apr 7, 2026 - MLB

Chicago White Sox
2 :  4
Baltimore Orioles

Apr 6, 2026 - MLB

Chicago White Sox
1 :  2
Baltimore Orioles

Apr 5, 2026 - MLB

Pittsburgh Pirates
8 :  2
Baltimore Orioles

Apr 4, 2026 - MLB

Pittsburgh Pirates
3 :  2
Baltimore Orioles

Apr 3, 2026 - MLB

Pittsburgh Pirates
5 :  4
Baltimore Orioles

Cleveland Guardians against Baltimore Orioles : Head to Head (H2H)

Cleveland Guardians

50 %

Baltimore Orioles

50 %

Jul 24, 2025 - MLB

Cleveland Guardians
3 :  4
Baltimore Orioles

Jul 23, 2025 - MLB

Cleveland Guardians
3 :  2
Baltimore Orioles

Jul 22, 2025 - MLB

Cleveland Guardians
6 :  3
Baltimore Orioles

Jul 21, 2025 - MLB

Cleveland Guardians
10 :  5
Baltimore Orioles

Apr 17, 2025 - MLB

Baltimore Orioles
6 :  2
Cleveland Guardians

Apr 16, 2025 - MLB

Baltimore Orioles
9 :  1
Cleveland Guardians

Cleveland Guardians - Baltimore Orioles Key Points

  1. Cleveland have won 5 of their last 7 at home
  2. Cleveland have won 3 of their last 4 at home to Baltimore
  3. Cleveland's last 3 wins have all been by 6+ runs
  4. Baltimore have given up 19 runs in their last 3 games

Our Cleveland Guardians vs Baltimore Orioles Prediction

Based on both teams' recent results, this looks like a very even matchup. However, we think the Guardians' significant pitching advantage will prove vital, so we are tipping them to record a vital home victory. 

It is also worth noting that all of Cleveland's recent victories have been by very wide margins. In other words, when they get it right, they are more than capable of sweeping teams aside with ease. 

Based on those factors, our prediction for Cleveland Guardians vs Baltimore Orioles is: Cleveland (-1) to win. 

Prediction:

 

Cleveland (-1) to win

+114
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Cleveland Guardians vs Baltimore Orioles Picks