Chicago White Sox vs Baltimore Orioles Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Lou Aguila | in MLB Picks
The Baltimore Orioles are in line to cover -1.5 runs (+122) with left-handed starter Trevor Rogers set to start again after posting a 2-0 record with a 1.38 ERA in his first two mound appearances this season.
Momentum: The Baltimore Orioles (4-6) edged the Chicago White Sox 2-1 in Game 1 to end their three-game losing streak. Meanwhile, after sweeping the Toronto Blue Jays, the Chicago White Sox (4-6) crashed back to earth with that loss on Monday.
Matchup: The Orioles took game 1 behind outstanding pitching from Brandon Young, who allowed two hits and zero runs through 5.2 innings. Baltimore is now 7-0 SU in its last 7 games against the Chicago White Sox.
Pitchers Matchup: Orioles left-handed pitcher Trevor Rogers (2-0, 1.38 ERA) will battle White Sox’s right-handed pitcher Shane Smith (0-2, 19.2 ERA).
Batters to watch out: The Orioles’ Gunnar Henderson has five hits in four games. The first baseman is batting .220 with three homers and seven RBIs this season. Munetaka Murakami has been as good as advertised for the White Sox, batting .206 with four RBIs and seven RBIs.
Hot on the Board: The White Sox are +122 underdogs at home, while the Orioles are -145 road favorites. The Orioles offer +122 odds if they can win by two runs or cover -1.5 runs in this game. The over/under is at seven runs.
Limited Offer. Currently at Caesars Sportsbook
Chicago White Sox vs Baltimore Orioles Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
10
|
0.521 | 117 | 61 | 56 |
|
21
|
0.479 | 119 | 57 | 62 |
Chicago White Sox and Baltimore Orioles Latest Matches
3/6 (50%)
3/6 (50%)
Apr 6, 2026 - MLB
Apr 5, 2026 - MLB
Apr 4, 2026 - MLB
Apr 3, 2026 - MLB
Apr 1, 2026 - MLB
Mar 31, 2026 - MLB
4/6 (67%)
2/6 (33%)
Apr 6, 2026 - MLB
Apr 5, 2026 - MLB
Apr 4, 2026 - MLB
Apr 3, 2026 - MLB
Mar 22, 2026 - MLB Spring Training
Mar 19, 2026 - MLB Spring Training
1/6 (17%)
5/6 (83%)
Apr 1, 2026 - MLB
Mar 31, 2026 - MLB
Mar 30, 2026 - MLB
Mar 29, 2026 - MLB
Mar 28, 2026 - MLB
Mar 26, 2026 - MLB
2/6 (33%)
4/6 (67%)
Apr 6, 2026 - MLB
Apr 5, 2026 - MLB
Apr 4, 2026 - MLB
Apr 3, 2026 - MLB
Apr 1, 2026 - MLB
Mar 31, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 1, 2026 - MLB
Mar 31, 2026 - MLB
Mar 30, 2026 - MLB
Mar 29, 2026 - MLB
Mar 28, 2026 - MLB
Mar 26, 2026 - MLB
2/6 (33%)
4/6 (67%)
Apr 6, 2026 - MLB
Apr 5, 2026 - MLB
Apr 4, 2026 - MLB
Apr 3, 2026 - MLB
Mar 23, 2026 - MLB Spring Training
Mar 20, 2026 - MLB Spring Training
Chicago White Sox against Baltimore Orioles : Head to Head (H2H)
0 %
100 %
Apr 6, 2026 - MLB
Sep 17, 2025 - MLB
Sep 16, 2025 - MLB
Sep 15, 2025 - MLB
Jun 1, 2025 - MLB
May 30, 2025 - MLB
Chicago White Sox - Baltimore Orioles Key Points
- Baltimore is 7-0 SU in its last 7 games against Chicago White Sox.
- Baltimore is 9-0 SU in its last 9 games when playing on the road against Chicago White Sox.
- Chicago White Sox is 6-12 SU in its last 18 games.
- Chicago White Sox is 3-10 SU in its last 13 games against an opponent in the American League.
Limited Offer. Currently at Caesars Sportsbook
Our Chicago White Sox vs Baltimore Orioles Prediction
Fearless Forecast: The Orioles extend dominance with a 4-2 win over the White Sox
Best Pick: The Orioles -1.5 Runs
Trevor Rogers has guided the Orioles to two wins in his first two starts this season, including an 8-3 win over the Rangers. Rogers is going to be a handful for the White Sox’s batters, who are hitting .216 with 0.4 homers and 3.8 runs per game against left-handed pitchers.
Again, the Birds have won their last seven meetings against the White Sox and 9 of their last 10 meetings. It’s going to be hard to convince me not to go with the Orioles in this game, especially with Rogers scheduled to hit the mound again.
Our betting prediction for the Baltimore Orioles vs. the Chicago White Sox: The Orioles -1.5 Runs
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
