San Francisco 49ers vs Atlanta Falcons Prediction & Picks - NFL

USA - NFL

San Francisco 49ers
10/19/25 20:20
Atlanta Falcons

Prediction:

 

Atlanta Falcons +3.5 Alternate Spread

-159
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Matt Lowrimore | in NFL Picks

The Week 7 Sunday slate in the NFL will conclude on Sunday night with an NFC game between the Atlanta Falcons and the San Francisco 49ers. Let’s take a look at the match statistics and predictions for this game between the Falcons and the 49ers.

Atlanta enters this game with a record of 3-2, having most recently beaten the Buffalo Bills in Week 6 by a score of 24-14. The Falcons’ offense had a total of 443 yards, while its defense allowed 291 yards. Quarterback Michael Penix Jr. threw for 250 yards and one touchdown, while running back Bijan Robinson led the team in rushing with 170 yards and one touchdown.

As for San Francisco, they enter this game with a record of 4-2, having most recently lost to the Tampa Bay Buccaneers in Week 6 by a score of 30-19. The 49ers’ offense had a total of 363 yards, while its defense allowed 352 yards. Quarterback Mac Jones threw for 347 yards and two interceptions, while running back Christian McCaffrey led the team in rushing with 54 yards and one touchdown.

San Francisco 49ers vs Atlanta Falcons Form

Table

Teams Pts P W L
7 San Francisco 49ers
0.706 17 12 5
17 Atlanta Falcons
0.471 17 8 9

San Francisco 49ers and Atlanta Falcons Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers

Oct 2, 2025 - NFL

Los Angeles Rams
23 :  26
San Francisco 49ers

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Dec 8, 2024 - NFL

San Francisco 49ers
38 :  13
Chicago Bears

Nov 17, 2024 - NFL

San Francisco 49ers
17 :  20
Seattle Seahawks
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers

Oct 2, 2025 - NFL

Los Angeles Rams
23 :  26
San Francisco 49ers

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 22, 2024 - NFL

Miami Dolphins
29 :  17
San Francisco 49ers
Atlanta Falcons
Atlanta Falcons Latest matches
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Sep 28, 2025 - NFL

Atlanta Falcons
34 :  27
Washington Commanders

Sep 21, 2025 - NFL

Carolina Panthers
30 :  0
Atlanta Falcons

Sep 14, 2025 - NFL

Minnesota Vikings
6 :  22
Atlanta Falcons

Sep 7, 2025 - NFL

Atlanta Falcons
20 :  23
Tampa Bay Buccaneers

Jan 5, 2025 - NFL

Atlanta Falcons
38 :  44
Carolina Panthers
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Sep 28, 2025 - NFL

Atlanta Falcons
34 :  27
Washington Commanders

Sep 7, 2025 - NFL

Atlanta Falcons
20 :  23
Tampa Bay Buccaneers

Jan 5, 2025 - NFL

Atlanta Falcons
38 :  44
Carolina Panthers

Dec 22, 2024 - NFL

Atlanta Falcons
34 :  7
New York Giants

Dec 1, 2024 - NFL

Atlanta Falcons
13 :  17
Los Angeles Chargers
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 21, 2025 - NFL

Carolina Panthers
30 :  0
Atlanta Falcons

Sep 14, 2025 - NFL

Minnesota Vikings
6 :  22
Atlanta Falcons

Dec 29, 2024 - NFL

Washington Commanders
30 :  24
Atlanta Falcons

Dec 16, 2024 - NFL

Las Vegas Raiders
9 :  15
Atlanta Falcons

Dec 8, 2024 - NFL

Minnesota Vikings
42 :  21
Atlanta Falcons

Nov 17, 2024 - NFL

Denver Broncos
38 :  6
Atlanta Falcons

San Francisco 49ers - Atlanta Falcons Key Points

  1. Atlanta is 3-2 ATS this season
  2. Atlanta is averaging 20.0 points per game this season
  3. San Francisco is 3-3 ATS this season
  4. San Francisco is averaging 20.8 points per game this season

Our San Francisco 49ers vs Atlanta Falcons Prediction

Atlanta may be a small underdog in this matchup with San Francisco, but still look to be the best betting option given their recent performances. The Falcons are coming off a huge win against the Bills, where running back Bijan Robinson had 238 scrimmage yards. Atlanta has now won each of their last two games by an average of 8.5 points per game. 

San Francisco, on the other hand, has lost two of their last three games. During this stretch, the 49ers have been a little inconsistent, averaging 22 points per game. Therefore, given that the Falcons are starting to become a real threat in the NFL, our San Francisco 49ers vs Atlanta Falcons prediction is: Atlanta Falcons +3.5 Alternate Spread.

Prediction:

 

Atlanta Falcons +3.5 Alternate Spread

-159
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

San Francisco 49ers vs Atlanta Falcons Picks