San Diego Padres vs Arizona Diamondbacks Prediction & Picks - MLB

USA - MLB

San Diego Padres
9/27/26 15:10
Arizona Diamondbacks

Prediction:

 

Arizona ML

−137
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 by Travis Pulver | in MLB Picks

The Arizona Diamondbacks (86-75, 41-39 Away), with their playoff aspirations on the line, will close out the regular season against the San Diego Padres (90-71, 50-30 Home) at Petco Park today. Fans can follow the action for the NL West battle once the game gets underway at 3:10 p.m. EST on MLB.TV.

Arizona had a chance to gain ground yesterday when the Phillies lost their fourth straight. But the Padres took control yesterday from the start, and led 6-4 after four innings and 10-4 after the sixth. The D-backs would tack on three in the ninth only to fall short 10-7 in the end.

Michael Soroka will get the start for the D-backs today. He is 9-5 in 21 appearances (20 starts), posting a 3.31 ERA and a 1.09 WHIP. Teams have hit .226 against him. When pitching on the road, he has gone 5-2 in nine appearances (eight starts) with a 4.11 ERA and a .218 OBA.

As for the hometown Padres, San Diego is set to go with Randy Vasquez on the mound. Vasquez is 10-6 in 31 appearances this season (22 starts), posting a 4.01 ERA, 1.30 WHIP, and teams have hit .267 off him. In home games, he has gone 6-4 in 15 appearances (11 starts) with a 3.97 ERA and a .255 OBA.

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San Diego Padres vs Arizona Diamondbacks Form

Table

Teams Pts P W L
6 San Diego Padres
0.562 162 91 71
10 Arizona Diamondbacks
0.531 162 86 76

San Diego Padres and Arizona Diamondbacks Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 25, 2026 - MLB

San Diego Padres
4 :  11
Arizona Diamondbacks

Sep 24, 2026 - MLB

Los Angeles Dodgers
2 :  4
San Diego Padres

Sep 23, 2026 - MLB

Los Angeles Dodgers
1 :  5
San Diego Padres

Sep 22, 2026 - MLB

Los Angeles Dodgers
7 :  0
San Diego Padres

Sep 20, 2026 - MLB

San Diego Padres
7 :  3
Miami Marlins

Sep 19, 2026 - MLB

San Diego Padres
7 :  6
Miami Marlins
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 25, 2026 - MLB

San Diego Padres
4 :  11
Arizona Diamondbacks

Sep 20, 2026 - MLB

San Diego Padres
7 :  3
Miami Marlins

Sep 19, 2026 - MLB

San Diego Padres
7 :  6
Miami Marlins

Sep 18, 2026 - MLB

San Diego Padres
8 :  2
Miami Marlins

Sep 9, 2026 - MLB

San Diego Padres
9 :  2
Washington Nationals

Sep 8, 2026 - MLB

San Diego Padres
5 :  4
Washington Nationals
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 24, 2026 - MLB

Los Angeles Dodgers
2 :  4
San Diego Padres

Sep 23, 2026 - MLB

Los Angeles Dodgers
1 :  5
San Diego Padres

Sep 22, 2026 - MLB

Los Angeles Dodgers
7 :  0
San Diego Padres

Sep 17, 2026 - MLB

Colorado Rockies
2 :  9
San Diego Padres

Sep 16, 2026 - MLB

Colorado Rockies
3 :  9
San Diego Padres

Sep 15, 2026 - MLB

Colorado Rockies
9 :  3
San Diego Padres
Arizona Diamondbacks
Arizona Diamondbacks Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 25, 2026 - MLB

San Diego Padres
4 :  11
Arizona Diamondbacks

Sep 24, 2026 - MLB

Colorado Rockies
8 :  12
Arizona Diamondbacks

Sep 23, 2026 - MLB

Colorado Rockies
3 :  5
Arizona Diamondbacks

Sep 22, 2026 - MLB

Colorado Rockies
2 :  7
Arizona Diamondbacks

Sep 20, 2026 - MLB

Arizona Diamondbacks
8 :  4
New York Yankees

Sep 19, 2026 - MLB

Arizona Diamondbacks
5 :  3
New York Yankees
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 20, 2026 - MLB

Arizona Diamondbacks
8 :  4
New York Yankees

Sep 19, 2026 - MLB

Arizona Diamondbacks
5 :  3
New York Yankees

Sep 18, 2026 - MLB

Arizona Diamondbacks
2 :  9
New York Yankees

Sep 16, 2026 - MLB

Arizona Diamondbacks
3 :  4
Miami Marlins

Sep 15, 2026 - MLB

Arizona Diamondbacks
2 :  4
Miami Marlins

Sep 14, 2026 - MLB

Arizona Diamondbacks
8 :  7
Miami Marlins
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 25, 2026 - MLB

San Diego Padres
4 :  11
Arizona Diamondbacks

Sep 24, 2026 - MLB

Colorado Rockies
8 :  12
Arizona Diamondbacks

Sep 23, 2026 - MLB

Colorado Rockies
3 :  5
Arizona Diamondbacks

Sep 22, 2026 - MLB

Colorado Rockies
2 :  7
Arizona Diamondbacks

Sep 9, 2026 - MLB

Kansas City Royals
5 :  2
Arizona Diamondbacks

Sep 8, 2026 - MLB

Kansas City Royals
3 :  5
Arizona Diamondbacks

San Diego Padres against Arizona Diamondbacks : Head to Head (H2H)

San Diego Padres

33 %

Arizona Diamondbacks

67 %

Sep 25, 2026 - MLB

San Diego Padres
4 :  11
Arizona Diamondbacks

Aug 6, 2026 - MLB

Arizona Diamondbacks
1 :  5
San Diego Padres

Aug 5, 2026 - MLB

Arizona Diamondbacks
10 :  4
San Diego Padres

Aug 4, 2026 - MLB

Arizona Diamondbacks
4 :  9
San Diego Padres

Aug 3, 2026 - MLB

Arizona Diamondbacks
5 :  1
San Diego Padres

Jul 9, 2026 - MLB

San Diego Padres
1 :  3
Arizona Diamondbacks
San Diego Padres vs Arizona Diamondbacks Picks

San Diego Padres - Arizona Diamondbacks Key Points

  1. San Diego has gone 21-17 vs. the D-backs over the last three seasons.
  2. San Diego is 45-35 ATS (run line) at home this season; Arizona is 41-39 ATS (run line)  on the road.
  3. The OVER is 36-40-4 for the Padres at home and 34-44-2 for the D-backs on the road.
  4. Betting Public: 59% of moneyline tickets and 84% of the handle are on Arizona.

Our San Diego Padres vs Arizona Diamondbacks Prediction

The D-backs have to smell blood in the water here. Philly has been struggling, and if they can continue to struggle today, a win will get them into the playoffs for the first time since losing the World Series to the Texas Rangers in 2023. Soroka has not faced the Padres this season, but Vasquez has played the Diamondbacks and held them scoreless in over six innings (August 4). But with the playoffs on the line, Arizona has been getting it done at the plate, hitting an MLB-best .315 over the last week and scoring 50 runs across six games. The D-backs bats will come through for the team today, too.

Our Arizona vs. San Diego Pick: D-backs ML

Prediction:

 

Arizona ML

−137
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.