Cincinnati Reds vs Arizona Diamondbacks Prediction & Picks - MLB
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by Travis Pulver | in MLB Picks
The Arizona Diamondbacks will try to get this road trip on track today when they face the Reds at Great America Ballpark in Cincinnati, OH. Fans can follow the action on Apple TV once the game gets underway at 7:15 p.m. EST.
The D-backs enter the series in desperate need of some offense after a disastrous series in Miami. After scoring six runs in a 10-6 loss to the Marlins on Tuesday, Arizona was shut out on Wednesday, 8-0, and again on Thursday, 2-0. Cincinnati will be looking to right the ship at home after going 1-5 in a road trip that ended on Wednesday with a 5-4 loss to the Padres in San Diego.
Arizona will have a distinct pitching advantage on the mound with Eduardo Rodriguez set to start the day. Rodriguez is 5-2 in 13 starts with a 2.52 ERA and a 1.18 WHIP. He has not had his best stuff on the road, where he is 2-1 in six starts with a 3.38 ERA and a .276 OBA.
As for the Reds, Nick Lodolo is scheduled to start. Lodolo has a 2-1 record in six starts with a 5.51 ERA and a 1.50 WHIP. In his three home starts, he is 1-1 with a 6.75 ERA and a .271 OBA.
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Cincinnati Reds vs Arizona Diamondbacks Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
10
|
0.531 | 162 | 86 | 76 |
|
24
|
0.463 | 162 | 75 | 87 |
Cincinnati Reds and Arizona Diamondbacks Latest Matches
1/6 (17%)
5/6 (83%)
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2/6 (33%)
4/6 (67%)
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1/6 (17%)
5/6 (83%)
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1/6 (17%)
5/6 (83%)
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2/6 (33%)
4/6 (67%)
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0/6 (0%)
6/6 (100%)
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Cincinnati Reds against Arizona Diamondbacks : Head to Head (H2H)
33 %
67 %
Mar 16, 2026 - MLB Spring Training
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Cincinnati Reds - Arizona Diamondbacks Key Points
- Cincinnati holds the all-time series lead vs. the D-backs, 90-89.
- The Reds are 15-17 ATS (run line) at home; the Diamondbacks are 18-15 ATS (run line) on the road.
- The OVER is 21-11 for Cincinnati at home and 17-14-2 for Arizona on the road.
- Betting Public: 66% of moneyline tickets and 69% of the handle is on Arizona.
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Our Cincinnati Reds vs Arizona Diamondbacks Prediction
Cincinnati has done a better job at the plate over the last week, hitting .252 to .192 for the D-backs. But they only scored 19 runs; Arizona recorded 12. So, I wouldn’t call that much of an advantage. However, Rodriguez is significantly better than Lodolo. So, I can see the D-backs coming to life against him more than Cincinnati doing much against Rodriguez. Because of the pitching disparity, I’m taking the D-backs to win outright (UNDER 9.5 also a good bet).
Our Arizona vs. Cincinnati Pick: Diamondbacks ML
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