Chicago Cubs vs Arizona Diamondbacks Prediction & Picks - MLB

USA - MLB

Chicago Cubs
5/1/26 14:20
Arizona Diamondbacks

Prediction:

 

Over 7.5 Runs

-102
$350 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Lou Aguila | in MLB Picks

Despite pitting two exceptional starters against each other on Friday, the Over 7.5 runs remains an appealing pick because of how strong the offense has turned out this season for the Chicago Cubs and the Arizona Diamondbacks.

Current Form:

The Arizona Diamondbacks have split their last four games, keeping them two games above .500 at 16-14. The D-Backs remain one of the worst pitching teams in baseball, posting a 5.12 ERA and 1.38 WHIP. Their offensive numbers are a little above league average at 4.8 runs per game on a .250 BA, but again, they are losing a ton of winnable games because of bad pitching.

The Cubs arrested their three-game losing streak with back-to-back wins over the San Diego Padres. The Cubs (19-12) still trail Cincinnati (20-11) in the NL Central standings, but this team is certainly oozing with potential because of their top-tier offense that produces 5.6 runs per game this season.

Starting Pitchers: Diamondbacks Zac Gallen (1-1, 3.14 ERA) vs. Cubs Collin Rea (3-1, 4.61 ERA)

Gallen is coming off a shutout stint (0 runs over 3 innings) against the Padres on April 25, but he gave up 6 earned runs the last time he pitched against the Cubs on April 19, 2025.

Rea surrendered 6 runs in his last start against the LA Dodgers on April 25. On the other hand, he has decent numbers (2.7 ER over 4.2 IP) across his last three starts against the D-backs.

Chicago Cubs vs Arizona Diamondbacks Form

Table

Teams Pts P W L
7 Chicago Cubs
0.542 83 45 38
13 Arizona Diamondbacks
0.5 82 41 41

Chicago Cubs and Arizona Diamondbacks Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 29, 2026 - MLB

San Diego Padres
4 :  5
Chicago Cubs

Apr 28, 2026 - MLB

San Diego Padres
3 :  8
Chicago Cubs

Apr 27, 2026 - MLB

San Diego Padres
9 :  7
Chicago Cubs

Apr 26, 2026 - MLB

Los Angeles Dodgers
6 :  0
Chicago Cubs

Apr 25, 2026 - MLB

Los Angeles Dodgers
12 :  4
Chicago Cubs

Apr 24, 2026 - MLB

Los Angeles Dodgers
4 :  6
Chicago Cubs
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 23, 2026 - MLB

Chicago Cubs
8 :  7
Philadelphia Phillies

Apr 22, 2026 - MLB

Chicago Cubs
7 :  2
Philadelphia Phillies

Apr 21, 2026 - MLB

Chicago Cubs
7 :  4
Philadelphia Phillies

Apr 20, 2026 - MLB

Chicago Cubs
5 :  1
Philadelphia Phillies

Apr 19, 2026 - MLB

Chicago Cubs
2 :  1
New York Mets

Apr 18, 2026 - MLB

Chicago Cubs
4 :  2
New York Mets
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 29, 2026 - MLB

San Diego Padres
4 :  5
Chicago Cubs

Apr 28, 2026 - MLB

San Diego Padres
3 :  8
Chicago Cubs

Apr 27, 2026 - MLB

San Diego Padres
9 :  7
Chicago Cubs

Apr 26, 2026 - MLB

Los Angeles Dodgers
6 :  0
Chicago Cubs

Apr 25, 2026 - MLB

Los Angeles Dodgers
12 :  4
Chicago Cubs

Apr 24, 2026 - MLB

Los Angeles Dodgers
4 :  6
Chicago Cubs
Arizona Diamondbacks
Arizona Diamondbacks Latest matches
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 30, 2026 - MLB

Milwaukee Brewers
13 :  1
Arizona Diamondbacks

Apr 29, 2026 - MLB

Milwaukee Brewers
2 :  6
Arizona Diamondbacks

Apr 28, 2026 - MLB

Milwaukee Brewers
13 :  2
Arizona Diamondbacks

Apr 26, 2026 - MLB

Arizona Diamondbacks
12 :  7
San Diego Padres

Apr 25, 2026 - MLB

Arizona Diamondbacks
4 :  6
San Diego Padres

Apr 23, 2026 - MLB

Arizona Diamondbacks
1 :  4
Chicago White Sox
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 26, 2026 - MLB

Arizona Diamondbacks
12 :  7
San Diego Padres

Apr 25, 2026 - MLB

Arizona Diamondbacks
4 :  6
San Diego Padres

Apr 23, 2026 - MLB

Arizona Diamondbacks
1 :  4
Chicago White Sox

Apr 22, 2026 - MLB

Arizona Diamondbacks
11 :  7
Chicago White Sox

Apr 21, 2026 - MLB

Arizona Diamondbacks
5 :  11
Chicago White Sox

Apr 19, 2026 - MLB

Arizona Diamondbacks
4 :  10
Toronto Blue Jays
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 30, 2026 - MLB

Milwaukee Brewers
13 :  1
Arizona Diamondbacks

Apr 29, 2026 - MLB

Milwaukee Brewers
2 :  6
Arizona Diamondbacks

Apr 28, 2026 - MLB

Milwaukee Brewers
13 :  2
Arizona Diamondbacks

Apr 15, 2026 - MLB

Baltimore Orioles
5 :  8
Arizona Diamondbacks

Apr 14, 2026 - MLB

Baltimore Orioles
3 :  4
Arizona Diamondbacks

Apr 13, 2026 - MLB

Baltimore Orioles
9 :  7
Arizona Diamondbacks

Chicago Cubs against Arizona Diamondbacks : Head to Head (H2H)

Chicago Cubs

67 %

Arizona Diamondbacks

33 %

Mar 18, 2026 - MLB Spring Training

Arizona Diamondbacks
16 :  8
Chicago Cubs

Mar 5, 2026 - MLB Spring Training

Chicago Cubs
8 :  1
Arizona Diamondbacks

Apr 19, 2025 - MLB

Chicago Cubs
6 :  2
Arizona Diamondbacks

Apr 18, 2025 - MLB

Chicago Cubs
13 :  11
Arizona Diamondbacks

Mar 30, 2025 - MLB

Arizona Diamondbacks
10 :  6
Chicago Cubs

Mar 29, 2025 - MLB

Arizona Diamondbacks
3 :  4
Chicago Cubs

Chicago Cubs - Arizona Diamondbacks Key Points

  1. The total has gone OVER in 8 of Chicago Cubs' last 9 games.
  2. The total has gone OVER in 4 of Chicago Cubs' last 5 games against an opponent in the National League.
  3. The total has gone OVER in 8 of Arizona's last 12 games.
  4. The total has gone OVER in 4 of Arizona's last 6 games on the road.

Our Chicago Cubs vs Arizona Diamondbacks Prediction

Back the total to go OVER at 7.5 runs. Zach Gallen and Collin Rea are strong pitchers for their respective squads, but they have been too erratic this season to be trusted in holding the other teams from scoring multiple runs. More so, the Cubs and the D-Backs continue to produce above-average numbers at the plate over their last five games. Chicago averages 4.8 runs per game, while Arizona averages 5.1 runs per contest over this five-game stretch.

Recent trends also favor the OVER. The total has gone OVER in 4 of Arizona's last 6 road games and 8 of the Chicago Cubs' last 9 games.

Our betting prediction for the Arizona Diamondbacks vs. the Chicago Cubs: The Over 7.5 Runs

Prediction:

 

Over 7.5 Runs

-102
$350 offered for betting!

FanDuel - Free Daily Dingers Game

FanDuel - Earn a Profit Boost with a Free Daily Dingers Game

With the MLB now back in full swing, FanDuel is currently offering an MLB-exclusive promotion for all its customers. To use this promo, navigate to the FanDuel homepage and click “Play Free” on the “Daily Dingers” tab at the top of the screen.

After doing so, you will be redirected to a page where you can select one player who you think will hit a home run during that day’s games.

If the player you picked hits a home run, your account will be credited with a profit boost token the following day. This token can then be used on any MLB game wager. Keep in mind that the bet you make with your profit boost token must have odds of -200 or longer.

Additionally, you can enter this “Daily Dinger” contest once every day, and this promotion will last the duration of the season, so be sure to take advantage of this promotion for the chance to earn a profit boost token every day of the season!

Take advantage now!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago Cubs vs Arizona Diamondbacks Picks