Iowa St. vs Tennessee Prediction & Picks - NCAA Basketball

USA - NCAA Basketball

Iowa St.
3/27/26 22:10
Tennessee

Prediction:

 

Iowa State Cyclones ML

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 by Matt Lowrimore | in NCAA Basketball Picks

The final Sweet 16 game on Friday night will see the #6-seeded Tennessee Volunteers (24-11) take on the #2-seeded Iowa State Cyclones (29-7) in the Midwest Region. Let’s take a look at the match statistics and predictions for this game between the Volunteers and the Cyclones.

Tennessee pulled away late in their Round of 32 game against the Virginia Cavaliers to win and punch their ticket to the Sweet 16. The Volunteers have now won four of their last six games, losing twice to the Vanderbilt Commodores in that stretch.  

Iowa State, on the other hand, has easily been one of the more impressive teams in the tournament, which was shown by the fact that they beat the Kentucky Wildcats in the Round of 32 by 19 points. The Cyclones are now 5-2 SU and 6-1 ATS over the same stretch. Additionally, the Cyclones have won their tournament games by an average margin of 26.5 points per game.

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Iowa St. vs Tennessee Form

Iowa St. and Tennessee Latest Matches

Iowa St.
Iowa St. Latest matches
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 22, 2026 - NCAA Basketball

Iowa St.
82 :  63
Kentucky Wildcats

Mar 20, 2026 - NCAA Basketball

Iowa St.
108 :  74
Tennessee State Tigers

Mar 23, 2025 - NCAA Basketball

Iowa St.
78 :  91
Ole Miss Rebels

Mar 21, 2025 - NCAA Basketball

Iowa St.
82 :  55
Lipscomb Bisons

Mar 28, 2024 - NCAA Basketball

Iowa St.
69 :  72
Illinois

Mar 23, 2024 - NCAA Basketball

Iowa St.
67 :  56
Wash. St.
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 22, 2026 - NCAA Basketball

Iowa St.
82 :  63
Kentucky Wildcats

Mar 20, 2026 - NCAA Basketball

Iowa St.
108 :  74
Tennessee State Tigers

Mar 23, 2025 - NCAA Basketball

Iowa St.
78 :  91
Ole Miss Rebels

Mar 21, 2025 - NCAA Basketball

Iowa St.
82 :  55
Lipscomb Bisons

Mar 28, 2024 - NCAA Basketball

Iowa St.
69 :  72
Illinois

Mar 23, 2024 - NCAA Basketball

Iowa St.
67 :  56
Wash. St.
Tennessee
Tennessee Latest matches
W W L W W
Victories

4/5 (80%)

Defeats

1/5 (20%)

Mar 22, 2026 - NCAA Basketball

Virginia Cavaliers
72 :  79
Tennessee

Mar 20, 2026 - NCAA Basketball

Tennessee
78 :  56
Miami (OH) Redhawks

Mar 30, 2025 - NCAA Basketball

Houston
69 :  50
Tennessee

Mar 22, 2025 - NCAA Basketball

Tennessee
67 :  58
UCLA Bruins

Mar 29, 2024 - NCAA Basketball

Tennessee
82 :  75
Creighton
W W W
Victories

3/3 (100%)

Defeats

0/3 (0%)

Mar 20, 2026 - NCAA Basketball

Tennessee
78 :  56
Miami (OH) Redhawks

Mar 22, 2025 - NCAA Basketball

Tennessee
67 :  58
UCLA Bruins

Mar 29, 2024 - NCAA Basketball

Tennessee
82 :  75
Creighton
L W
Victories

1/2 (50%)

Defeats

1/2 (50%)

Mar 22, 2026 - NCAA Basketball

Virginia Cavaliers
72 :  79
Tennessee

Mar 30, 2025 - NCAA Basketball

Houston
69 :  50
Tennessee

Iowa St. - Tennessee Key Points

  1. Tennessee is 4-2 ATS in March
  2. Tennessee is 4-2 SU in March
  3. Iowa State is 6-1 ATS in March
  4. Iowa State is 5-2 SU in March
Up to $200 to bet on Iowa St. - Tennessee! 

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Our Iowa St. vs Tennessee Prediction

Iowa State is the clear favorite in this game; however, they still look to be the best betting option. Through two games in the tournament, it is easy to say that Iowa State has been the much more efficient offense. The Cyclones are averaging 95.0 points per game in the tournament, compared to Tennessee, which is averaging 78.5 points per game. 

Even though this includes a 108-point output against #15-seeded Tennessee State in the first round, Iowa State manhandled Kentucky, a team that Tennessee failed to beat once this season. 

Further, Iowa State crushed Kentucky without one of their top players, that being Joshua Jefferson. He was sidelined with an injury, but hopes to return for this Sweet 16 matchup against Tennessee. Even if Jefferson is unable to play, the Cyclones have plenty of depth to make up for his potential absence. 

Simply put, Iowa State looks to be the better team with or without Jefferson; therefore, our Tennessee Volunteers vs Iowa State Cyclones prediction is: Iowa State Cyclones ML.

Prediction:

 

Iowa State Cyclones ML

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Iowa St. vs Tennessee Picks