St. Louis Cardinals vs Tampa Bay Rays Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
8/21/25 19:35
Tampa Bay Rays

Prediction:

 

Cardinals will cover -1.5 Runs

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 by Lou Aguila | in MLB Picks

The St. Louis Cardinals will attempt to keep their winning form going, as they target their third win in four games in Thursday’s series opener against the Tampa Bay Rays at George Steinbrenner Field.

The Cardinals took 2 out of 3 games in their previous series with the Miami Marlins. Although they could not complete a sweep after dropping Game 3, 2-6, St. Louis still bumped up their regular-season record to 63-65, fourth in the NL Central. St. Louis will still be missing the service of second baseman Brendan Donovan, who was placed on the injured list Monday with a left groin strain.

Meanwhile, the Rays are coming into the new series with deflated confidence after absorbing back-to-back losses in their two-game series with the New York Yankees. Tampa Bay lost Game 1 in a blowout, 3-13, before losing Game 2, 4-6, in extra innings after letting Giancarlo Stanton and Austin Wells homer in the 10th inning.

St. Louis Cardinals vs Tampa Bay Rays Form

Table

Teams % P W L
16
St. Louis Cardinals
St. Louis Cardinals
0.492 128 63 65
19
Tampa Bay Rays
Tampa Bay Rays
0.48 127 61 66

St. Louis Cardinals and Tampa Bay Rays Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 20, 2025 - MLB

St. Louis Cardinals
2 :  6
Miami Marlins

Aug 19, 2025 - MLB

St. Louis Cardinals
7 :  4
Miami Marlins

Aug 18, 2025 - MLB

St. Louis Cardinals
8 :  3
Miami Marlins

Aug 17, 2025 - MLB

New York Yankees
8 :  4
St. Louis Cardinals

Aug 16, 2025 - MLB

New York Yankees
12 :  8
St. Louis Cardinals

Aug 15, 2025 - MLB

New York Yankees
4 :  3
St. Louis Cardinals
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 17, 2025 - MLB

New York Yankees
8 :  4
St. Louis Cardinals

Aug 16, 2025 - MLB

New York Yankees
12 :  8
St. Louis Cardinals

Aug 15, 2025 - MLB

New York Yankees
4 :  3
St. Louis Cardinals

Aug 13, 2025 - MLB

Colorado Rockies
6 :  5
St. Louis Cardinals

Aug 12, 2025 - MLB

Colorado Rockies
3 :  0
St. Louis Cardinals

Aug 11, 2025 - MLB

Colorado Rockies
2 :  3
St. Louis Cardinals
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 20, 2025 - MLB

St. Louis Cardinals
2 :  6
Miami Marlins

Aug 19, 2025 - MLB

St. Louis Cardinals
7 :  4
Miami Marlins

Aug 18, 2025 - MLB

St. Louis Cardinals
8 :  3
Miami Marlins

Aug 6, 2025 - MLB

St. Louis Cardinals
5 :  3
Los Angeles Dodgers

Aug 5, 2025 - MLB

St. Louis Cardinals
6 :  12
Los Angeles Dodgers

Aug 4, 2025 - MLB

St. Louis Cardinals
3 :  2
Los Angeles Dodgers
Tampa Bay Rays
Tampa Bay Rays Latest matches
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 20, 2025 - MLB

New York Yankees
6 :  4
Tampa Bay Rays

Aug 19, 2025 - MLB

New York Yankees
13 :  3
Tampa Bay Rays

Aug 17, 2025 - MLB

Tampa Bay Rays
1 :  7
San Francisco Giants

Aug 16, 2025 - MLB

Tampa Bay Rays
2 :  1
San Francisco Giants

Aug 15, 2025 - MLB

Tampa Bay Rays
7 :  6
San Francisco Giants

Aug 13, 2025 - MLB

Tampa Bay Rays
8 :  2
Athletics
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 20, 2025 - MLB

New York Yankees
6 :  4
Tampa Bay Rays

Aug 19, 2025 - MLB

New York Yankees
13 :  3
Tampa Bay Rays

Aug 3, 2025 - MLB

Los Angeles Dodgers
3 :  0
Tampa Bay Rays

Aug 2, 2025 - MLB

Los Angeles Dodgers
0 :  4
Tampa Bay Rays

Aug 1, 2025 - MLB

Los Angeles Dodgers
5 :  0
Tampa Bay Rays

Jul 23, 2025 - MLB

Chicago White Sox
11 :  9
Tampa Bay Rays
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 17, 2025 - MLB

Tampa Bay Rays
1 :  7
San Francisco Giants

Aug 16, 2025 - MLB

Tampa Bay Rays
2 :  1
San Francisco Giants

Aug 15, 2025 - MLB

Tampa Bay Rays
7 :  6
San Francisco Giants

Aug 13, 2025 - MLB

Tampa Bay Rays
8 :  2
Athletics

Aug 12, 2025 - MLB

Tampa Bay Rays
0 :  6
Athletics

Aug 11, 2025 - MLB

Tampa Bay Rays
7 :  4
Athletics

St. Louis Cardinals against Tampa Bay Rays : Head to Head (H2H)

Aug 8, 2023 - MLB

St. Louis Cardinals
2 :  4
Tampa Bay Rays

St. Louis Cardinals - Tampa Bay Rays Key Points

  1. St. Louis is 4-1 SU in its last 5 games against Tampa Bay.
  2. St. Louis is 4-2 SU in its last 6 games on the road.
  3. Tampa Bay is 7-13 SU in its last 20 games.
  4. Tampa Bay is 1-5 SU in its last 6 games at home.

Our St. Louis Cardinals vs Tampa Bay Rays Prediction

Pick the Cardinals -1.5 Runs.

The Cardinals are 4-1 in their last five games against the Rays and 4-2 on the road. They may never go beyond September this year, but St. Louis has shown characteristics of a future playoff team in the coming years. In their last three meetings against the Rays, they have held Tampa Bay to an average of 3.67 runs while scoring 4.33 runs per game.

The Cards have tapped starting pitcher Sonny Grey, who squandered six earned runs over five innings in his last start vs. the Yankees, but averages only 2.3 earned runs over his last three starts against the Rays. Tampa Bay, meanwhile, will dispatch right-handed pitcher Joe Boyle. Boyle, who has allowed a total of 10 runs over his last two starts, will be pitching against the Cardinals for the first time in his career. St. Louis could take advantage of a still unseasoned Boyle as they try to take the early lead. The Rays starters have given up a 6.65 ERA over the last five games. Furthermore, Tampa Bay is only averaging 3.3 runs per game over this stretch, which could put them at a disadvantage against a team that is scoring almost six runs a game (5.8 runs per game) in their last five games.

Our betting prediction for the Tampa Bay Rays vs. St. Louis Cardinals: The Cardinals -1.5 Runs.

Prediction:

 

Cardinals will cover -1.5 Runs

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St. Louis Cardinals vs Tampa Bay Rays Picks