St. Louis Cardinals vs Seattle Mariners Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
9/10/25 21:40
Seattle Mariners

Prediction:

 

Mariners -1.5.

-108
$300 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Carlos Zabala | in MLB Picks

The Mariners have a five-man starting rotation with notable career numbers. Their latest trade deadline additions make them a team that will easily be in the top 7 of MLB's most home run-hitting teams. They have speed on the bases, excellent defense, and, if that weren't enough, a city rooting for them to win their first World Series.

There are no excuses for the Mariners to miss the playoffs this season, so a solid September like the one they're having is necessary to secure the last Wild Card or take the division lead from the Astros.

The Mariners won their last four games with home runs; it was a good run that began with a 10-2 thrashing of the Braves on September 2nd, when Raleigh, Naylor, and Suárez homered, and Julio Rodríguez hit two home runs. The next game, they won 18-2. Another day, Suárez had two home runs, and Raleigh hit his 53rd of the season.

The Mariners won the first game of the series against the Cardinals 4-2, and in Tuesday's 5-3 victory, Arozarena hit his 27th home run of the year and Naylor his 19th.

St. Louis Cardinals vs Seattle Mariners Form

Table

Teams % P W L
7
Seattle Mariners
Seattle Mariners
0.556 162 90 72
20
St. Louis Cardinals
St. Louis Cardinals
0.481 162 78 84

St. Louis Cardinals and Seattle Mariners Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 9, 2025 - MLB

St. Louis Cardinals
3 :  5
Seattle Mariners

Sep 8, 2025 - MLB

St. Louis Cardinals
2 :  4
Seattle Mariners

Sep 7, 2025 - MLB

San Francisco Giants
3 :  4
St. Louis Cardinals

Sep 6, 2025 - MLB

San Francisco Giants
2 :  3
St. Louis Cardinals

Sep 5, 2025 - MLB

San Francisco Giants
8 :  2
St. Louis Cardinals

Sep 3, 2025 - MLB

Athletics
1 :  5
St. Louis Cardinals
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 7, 2025 - MLB

San Francisco Giants
3 :  4
St. Louis Cardinals

Sep 6, 2025 - MLB

San Francisco Giants
2 :  3
St. Louis Cardinals

Sep 5, 2025 - MLB

San Francisco Giants
8 :  2
St. Louis Cardinals

Sep 3, 2025 - MLB

Athletics
1 :  5
St. Louis Cardinals

Sep 2, 2025 - MLB

Athletics
1 :  2
St. Louis Cardinals

Sep 1, 2025 - MLB

Athletics
11 :  3
St. Louis Cardinals
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 9, 2025 - MLB

St. Louis Cardinals
3 :  5
Seattle Mariners

Sep 8, 2025 - MLB

St. Louis Cardinals
2 :  4
Seattle Mariners

Aug 31, 2025 - MLB

St. Louis Cardinals
4 :  7
Cincinnati Reds

Aug 30, 2025 - MLB

St. Louis Cardinals
4 :  2
Cincinnati Reds

Aug 29, 2025 - MLB

St. Louis Cardinals
7 :  5
Cincinnati Reds

Aug 24, 2025 - MLB

St. Louis Cardinals
2 :  7
Tampa Bay Rays
Seattle Mariners
Seattle Mariners Latest matches
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 9, 2025 - MLB

St. Louis Cardinals
3 :  5
Seattle Mariners

Sep 8, 2025 - MLB

St. Louis Cardinals
2 :  4
Seattle Mariners

Sep 7, 2025 - MLB

Seattle Mariners
18 :  2
Atlanta Braves

Sep 6, 2025 - MLB

Seattle Mariners
10 :  2
Atlanta Braves

Sep 5, 2025 - MLB

Seattle Mariners
1 :  4
Atlanta Braves

Sep 3, 2025 - MLB

Seattle Mariners
4 :  9
Tampa Bay Rays
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 9, 2025 - MLB

St. Louis Cardinals
3 :  5
Seattle Mariners

Sep 8, 2025 - MLB

St. Louis Cardinals
2 :  4
Seattle Mariners

Aug 27, 2025 - MLB

San Diego Padres
3 :  4
Seattle Mariners

Aug 26, 2025 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Aug 25, 2025 - MLB

San Diego Padres
6 :  9
Seattle Mariners

Aug 24, 2025 - MLB

Athletics
4 :  11
Seattle Mariners
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 7, 2025 - MLB

Seattle Mariners
18 :  2
Atlanta Braves

Sep 6, 2025 - MLB

Seattle Mariners
10 :  2
Atlanta Braves

Sep 5, 2025 - MLB

Seattle Mariners
1 :  4
Atlanta Braves

Sep 3, 2025 - MLB

Seattle Mariners
4 :  9
Tampa Bay Rays

Sep 2, 2025 - MLB

Seattle Mariners
5 :  6
Tampa Bay Rays

Sep 1, 2025 - MLB

Seattle Mariners
2 :  10
Tampa Bay Rays

St. Louis Cardinals against Seattle Mariners : Head to Head (H2H)

St. Louis Cardinals

33 %

Seattle Mariners

67 %

Sep 9, 2025 - MLB

St. Louis Cardinals
3 :  5
Seattle Mariners

Sep 8, 2025 - MLB

St. Louis Cardinals
2 :  4
Seattle Mariners

Sep 8, 2024 - MLB

Seattle Mariners
10 :  4
St. Louis Cardinals

Apr 22, 2023 - MLB

St. Louis Cardinals
4 :  5
Seattle Mariners

Jul 4, 2019 - MLB

St. Louis Cardinals
5 :  4
Seattle Mariners

Jul 3, 2019 - MLB

St. Louis Cardinals
5 :  2
Seattle Mariners

St. Louis Cardinals - Seattle Mariners Key Points

  1. Muñoz earned his 34th save of the season with the Mariners on Tuesday
  2. The Mariners hit 210 home runs, the second-most home runs in 2025
  3. The Mariners have the fourth-most stolen bases in MLB this season with 141
  4. The Mariners have a 43-27 record at T-Mobile Park

Our St. Louis Cardinals vs Seattle Mariners Prediction

A lot is in flux for the Mariners in 2025. It's impossible not to mention the great season of Cal Raleigh, who is the betting favorite behind Judge to win the MVP.

Raleigh is a two-handed hitter who, at a pitching park like T-Mobile, has led MLB in home runs all year, even playing catcher every day.

In addition, the Mariners have re-signed Suárez, who was a significant player at the trade deadline and currently ranks fourth in the home run list this season.

As if that weren't enough, Dominican Julio Rodríguez is having a splendid second half. The Mariners should win on Wednesday.

Our prediction for Mariners vs Cardinals is: Mariners -1.5.

Prediction:

 

Mariners -1.5.

-108
$300 offered for betting!

Grab an extra $300 for your St. Louis Cardinals vs Seattle Mariners wager!

Bet $5, Get $300

Get ready to experience the thrill of the game with FanDuel's exciting welcome offer, available for use on the St. Louis Cardinals vs Seattle Mariners matchup!

A minimum bet of $5 will qualify for $300 in bonus bets if your bet wins! This offer is a golden opportunity for new users. Don't miss out on this limited-time deal to enhance your sports betting experience with some extra oomph! Jump into the action today and let FanDuel take your sports engagement to the next level!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

St. Louis Cardinals vs Seattle Mariners Picks