St. Louis Cardinals vs Baltimore Orioles Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
5/28/25 18:35
Baltimore Orioles

Prediction:

 

Cardinals ML.

+100
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 by Carlos Zabala in MLB Picks

The Orioles' poor pitching again left their team without a chance on Tuesday, ending their three-game winning streak after they had a 5-2 win over the Cardinals in the series opener.

In the second, St. Louis started as a slight favorite in the betting games at odds around -120. Nootbaar hit a two-run home run to put the Cardinals ahead. The Orioles seemed hopeless, but the fiery O. Hearn continued his strong form, hitting a three-run home run to turn the score around. But Winn later tied the game at 4-4, and in the next inning, Arenado hit a home run followed by a pair of triples by Barrero and Walker. Winn drove in the Cardinals' final run on a night of strong hitting and 14 hits to win the game 7-4.

Orioles starter Sugano is struggling to get the first outs in games, but he managed to pitch five innings. On Tuesday, it was reliever Baker who took the brunt, allowing three earned runs. The opposite was true for the Cards' bullpen, with Maton and Helsley closing the gap without allowing a run and striking out three between them.

St. Louis Cardinals vs Baltimore Orioles Form

Table

Teams % P W L
8
St. Louis Cardinals
St. Louis Cardinals
0.571 56 32 24
28
Baltimore Orioles
Baltimore Orioles
0.345 55 19 36

St. Louis Cardinals and Baltimore Orioles Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 27, 2025 - MLB

St. Louis Cardinals
7 :  4
Baltimore Orioles

May 26, 2025 - MLB

St. Louis Cardinals
2 :  5
Baltimore Orioles

May 25, 2025 - MLB

Arizona Diamondbacks
3 :  4
St. Louis Cardinals

May 24, 2025 - MLB

Arizona Diamondbacks
5 :  6
St. Louis Cardinals

May 23, 2025 - MLB

Arizona Diamondbacks
3 :  4
St. Louis Cardinals

May 21, 2025 - MLB

Detroit Tigers
5 :  1
St. Louis Cardinals
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 25, 2025 - MLB

Arizona Diamondbacks
3 :  4
St. Louis Cardinals

May 24, 2025 - MLB

Arizona Diamondbacks
5 :  6
St. Louis Cardinals

May 23, 2025 - MLB

Arizona Diamondbacks
3 :  4
St. Louis Cardinals

May 21, 2025 - MLB

Detroit Tigers
5 :  1
St. Louis Cardinals

May 20, 2025 - MLB

Detroit Tigers
5 :  4
St. Louis Cardinals

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 27, 2025 - MLB

St. Louis Cardinals
7 :  4
Baltimore Orioles

May 26, 2025 - MLB

St. Louis Cardinals
2 :  5
Baltimore Orioles

May 18, 2025 - MLB

St. Louis Cardinals
1 :  2
Kansas City Royals

May 17, 2025 - MLB

St. Louis Cardinals
1 :  0
Kansas City Royals

May 16, 2025 - MLB

St. Louis Cardinals
10 :  3
Kansas City Royals

May 14, 2025 - MLB

St. Louis Cardinals
14 :  7
Philadelphia Phillies
Baltimore Orioles
Baltimore Orioles Latest matches
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 27, 2025 - MLB

St. Louis Cardinals
7 :  4
Baltimore Orioles

May 26, 2025 - MLB

St. Louis Cardinals
2 :  5
Baltimore Orioles

May 25, 2025 - MLB

Baltimore Orioles
5 :  1
Boston Red Sox

May 24, 2025 - MLB

Baltimore Orioles
2 :  1
Boston Red Sox

May 24, 2025 - MLB

Baltimore Orioles
5 :  6
Boston Red Sox

May 23, 2025 - MLB

Baltimore Orioles
5 :  19
Boston Red Sox
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 27, 2025 - MLB

St. Louis Cardinals
7 :  4
Baltimore Orioles

May 26, 2025 - MLB

St. Louis Cardinals
2 :  5
Baltimore Orioles

May 18, 2025 - MLB

Washington Nationals
10 :  4
Baltimore Orioles

May 17, 2025 - MLB

Washington Nationals
10 :  6
Baltimore Orioles

May 16, 2025 - MLB

Washington Nationals
4 :  3
Baltimore Orioles

May 15, 2025 - MLB

Minnesota Twins
4 :  0
Baltimore Orioles
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 25, 2025 - MLB

Baltimore Orioles
5 :  1
Boston Red Sox

May 24, 2025 - MLB

Baltimore Orioles
2 :  1
Boston Red Sox

May 24, 2025 - MLB

Baltimore Orioles
5 :  6
Boston Red Sox

May 23, 2025 - MLB

Baltimore Orioles
5 :  19
Boston Red Sox

May 21, 2025 - MLB

Baltimore Orioles
8 :  4
Milwaukee Brewers

May 20, 2025 - MLB

Baltimore Orioles
2 :  5
Milwaukee Brewers

St. Louis Cardinals against Baltimore Orioles : Head to Head (H2H)

St. Louis Cardinals

60 %

Baltimore Orioles

40 %

May 27, 2025 - MLB

St. Louis Cardinals
7 :  4
Baltimore Orioles

May 26, 2025 - MLB

St. Louis Cardinals
2 :  5
Baltimore Orioles

Sep 12, 2023 - MLB

St. Louis Cardinals
5 :  2
Baltimore Orioles

Sep 11, 2023 - MLB

St. Louis Cardinals
5 :  11
Baltimore Orioles

May 11, 2022 - MLB

Baltimore Orioles
1 :  10
St. Louis Cardinals

St. Louis Cardinals - Baltimore Orioles Key Points

  1. Nootbaar went 3-for-4 with a home run in Game 2 against the Orioles
  2. Cardinals' pitching saw 11 strikeouts in Tuesday's game
  3. O'Hearn averages over .340 to start 2025
  4. Arenado hit his 6th home run of the season in his last win

Our St. Louis Cardinals vs Baltimore Orioles Prediction

Mikolas will be the Cardinals' starter. The 36-year-old veteran right-hander, unlike in 2024, is putting up numbers that exceed the team's expectations. In fact, the Cardinals have won each of his last 5 starts, and their record is 4-2. In 4 of those 5 wins, the Cardinals were underdogs when Mikolas pitched. Mikolas pitched 6 innings in previous outings against the Royals and D-backs. Our prediction for Cardinals vs Orioles is: Cardinals ML.

Prediction:

 

Cardinals ML.

+100
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St. Louis Cardinals vs Baltimore Orioles Picks