TCU Horned Frogs vs SMU Mustangs Prediction & Picks - NCAA

USA - NCAA

TCU Horned Frogs
9/20/25 12:00
SMU Mustangs

Prediction:

 

TCU ML

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 by Matt Lowrimore | in NCAA Picks

Another one of the interesting matchups on the Week 4 college football slate will see the SMU Mustangs take on the TCU Horned Frogs. Let’s take a look at the match statistics and predictions for this game between the Mustangs and the Horned Frogs.

SMU enters this game with a record of 2-1, having most recently beaten the Missouri State Bears by a score of 28-10. The Mustangs’ offense had a total of 448 yards, while its defense allowed 328 yards. Quarterback Kevin Jennings threw for 281 yards, one touchdown, and one interception, while running back T.J. Harden led the team in rushing with 96 yards and two touchdowns.

As for TCU, they enter this game with a record of 2-0, having most recently beaten the Abilene Christian Wildcats by a score of 42-21 in Week 3. TCU’s offense had a total of 490 yards, while its defense allowed 453 yards. Quarterback Josh Hoover threw for 337 yards and four touchdowns, while running back Kevorian Barnes led the team in rushing with 43 yards.

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TCU Horned Frogs vs SMU Mustangs Form

Table

TCU Horned Frogs and SMU Mustangs Latest Matches

TCU Horned Frogs
TCU Horned Frogs Latest matches
L W W
Victories

2/3 (67%)

Defeats

1/3 (33%)

Sep 13, 2025 - NCAA

TCU Horned Frogs
42 :  21
Abilene Christian Wildcats

Sep 1, 2025 - NCAA

North Carolina Tar Heels
14 :  48
TCU Horned Frogs

Sep 14, 2024 - NCAA

TCU Horned Frogs
34 :  35
UCF Knights
L W
Victories

1/2 (50%)

Defeats

1/2 (50%)

Sep 13, 2025 - NCAA

TCU Horned Frogs
42 :  21
Abilene Christian Wildcats

Sep 14, 2024 - NCAA

TCU Horned Frogs
34 :  35
UCF Knights
W
Victories

1/1 (100%)

Defeats

0/1 (0%)

Sep 1, 2025 - NCAA

North Carolina Tar Heels
14 :  48
TCU Horned Frogs
SMU Mustangs
SMU Mustangs Latest matches
L L W L W
Victories

2/5 (40%)

Defeats

3/5 (60%)

Sep 13, 2025 - NCAA

Missouri State Bears
10 :  28
SMU Mustangs

Sep 6, 2025 - NCAA

SMU Mustangs
45 :  48
Baylor Bears

Aug 30, 2025 - NCAA

SMU Mustangs
42 :  13
East Texas AM Lions

Dec 21, 2024 - NCAA

Penn State Nittany Lions
38 :  10
SMU Mustangs

Sep 6, 2024 - NCAA

SMU Mustangs
15 :  18
BYU Cougars
L W L
Victories

1/3 (33%)

Defeats

2/3 (67%)

Sep 6, 2025 - NCAA

SMU Mustangs
45 :  48
Baylor Bears

Aug 30, 2025 - NCAA

SMU Mustangs
42 :  13
East Texas AM Lions

Sep 6, 2024 - NCAA

SMU Mustangs
15 :  18
BYU Cougars
L W
Victories

1/2 (50%)

Defeats

1/2 (50%)

Sep 13, 2025 - NCAA

Missouri State Bears
10 :  28
SMU Mustangs

Dec 21, 2024 - NCAA

Penn State Nittany Lions
38 :  10
SMU Mustangs

TCU Horned Frogs - SMU Mustangs Key Points

  1. TCU averages 45.0 points per game this season
  2. TCU allows an average of 17.5 points per game this season
  3. SMU averages 38.3 points per game this season
  4. SMU allows an average of 22.7 points per game this season
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Our TCU Horned Frogs vs SMU Mustangs Prediction

TCU may have only played two games this season, but has won by at least three touchdowns in each game. Their offense has been electric this season, averaging 45.0 points per game, and while there might be some concern around their defense, having allowed 21 points to Abilene Christian, their offense more than makes up for this by being able to score points consistently. 

SMU, on the other hand, only has one loss this season, that being to Baylor in double overtime. The Mustangs were leading for most of the game, including with about six minutes left, but could not hang on back in Week 2. The Mustangs responded with an 18-point win against Missouri State in Week 3; however, this game against TCU will be a much tougher test.

The Mustangs have had moments this season of looking like a great team, but having already had trouble closing out a game, our SMU Mustangs vs TCU Horned Frogs prediction is: TCU Horned Frogs ML.

Prediction:

 

TCU ML

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

TCU Horned Frogs vs SMU Mustangs Picks