SMU Mustangs vs TCU Horned Frogs Prediction & Picks - NCAA

USA - NCAA

SMU Mustangs
9/20/25 12:00
TCU Horned Frogs

Prediction:

 

TCU ML

-250
$400+ offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Matt Lowrimore in NCAA Picks

Another one of the interesting matchups on the Week 4 college football slate will see the SMU Mustangs take on the TCU Horned Frogs. Let’s take a look at the match statistics and predictions for this game between the Mustangs and the Horned Frogs.

SMU enters this game with a record of 2-1, having most recently beaten the Missouri State Bears by a score of 28-10. The Mustangs’ offense had a total of 448 yards, while its defense allowed 328 yards. Quarterback Kevin Jennings threw for 281 yards, one touchdown, and one interception, while running back T.J. Harden led the team in rushing with 96 yards and two touchdowns.

As for TCU, they enter this game with a record of 2-0, having most recently beaten the Abilene Christian Wildcats by a score of 42-21 in Week 3. TCU’s offense had a total of 490 yards, while its defense allowed 453 yards. Quarterback Josh Hoover threw for 337 yards and four touchdowns, while running back Kevorian Barnes led the team in rushing with 43 yards.

Up to $400+ to bet on SMU Mustangs - TCU Horned Frogs! 

Limited Offer. Currently at DraftKings

SMU Mustangs vs TCU Horned Frogs Form

Table

Teams % P W D L
6
SMU Mustangs
SMU Mustangs
0 0 0 0 0
11
TCU Horned Frogs
TCU Horned Frogs
0 0 0 0 0

SMU Mustangs and TCU Horned Frogs Latest Matches

SMU Mustangs
SMU Mustangs Latest matches
W L L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 13, 2025 - NCAA

SMU Mustangs
28 :  10
Missouri State Bears

Sep 6, 2025 - NCAA

Baylor Bears
48 :  45
SMU Mustangs

Aug 30, 2025 - NCAA

East Texas AM Lions
13 :  42
SMU Mustangs

Dec 21, 2024 - NCAA

SMU Mustangs
10 :  38
Penn State Nittany Lions

Dec 7, 2024 - NCAA

Clemson Tigers
34 :  31
SMU Mustangs

Nov 30, 2024 - NCAA

California Golden Bears
6 :  38
SMU Mustangs
W W W L W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 6, 2025 - NCAA

Baylor Bears
48 :  45
SMU Mustangs

Aug 30, 2025 - NCAA

East Texas AM Lions
13 :  42
SMU Mustangs

Dec 7, 2024 - NCAA

Clemson Tigers
34 :  31
SMU Mustangs

Nov 30, 2024 - NCAA

California Golden Bears
6 :  38
SMU Mustangs

Nov 16, 2024 - NCAA

Boston College Eagles
28 :  38
SMU Mustangs

Nov 2, 2024 - NCAA

Pittsburgh Panthers
25 :  48
SMU Mustangs
W W W W L W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 13, 2025 - NCAA

SMU Mustangs
28 :  10
Missouri State Bears

Dec 21, 2024 - NCAA

SMU Mustangs
10 :  38
Penn State Nittany Lions

Nov 23, 2024 - NCAA

SMU Mustangs
33 :  7
Virginia Cavaliers

Oct 26, 2024 - NCAA

SMU Mustangs
28 :  27
Duke Blue Devils

Oct 19, 2024 - NCAA

SMU Mustangs
40 :  10
Stanford Cardinal

Oct 5, 2024 - NCAA

SMU Mustangs
34 :  27
Louisville Cardinals
TCU Horned Frogs
TCU Horned Frogs Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 13, 2025 - NCAA

Abilene Christian Wildcats
21 :  42
TCU Horned Frogs

Sep 1, 2025 - NCAA

TCU Horned Frogs
48 :  14
North Carolina Tar Heels

Dec 28, 2024 - NCAA Division I, FBS, Playoffs

Louisiana-Lafayette Ragin Cajuns
3 :  34
TCU Horned Frogs

Nov 30, 2024 - NCAA

TCU Horned Frogs
20 :  13
Cincinnati Bearcats

Nov 23, 2024 - NCAA

Arizona Wildcats
28 :  49
TCU Horned Frogs

Nov 9, 2024 - NCAA

Oklahoma State Cowboys
13 :  38
TCU Horned Frogs
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 13, 2025 - NCAA

Abilene Christian Wildcats
21 :  42
TCU Horned Frogs

Dec 28, 2024 - NCAA Division I, FBS, Playoffs

Louisiana-Lafayette Ragin Cajuns
3 :  34
TCU Horned Frogs

Nov 23, 2024 - NCAA

Arizona Wildcats
28 :  49
TCU Horned Frogs

Nov 9, 2024 - NCAA

Oklahoma State Cowboys
13 :  38
TCU Horned Frogs

Oct 26, 2024 - NCAA

Texas Tech Red Raiders
34 :  35
TCU Horned Frogs

Oct 4, 2024 - NCAA

Houston Cougars
30 :  19
TCU Horned Frogs
L W W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 1, 2025 - NCAA

TCU Horned Frogs
48 :  14
North Carolina Tar Heels

Nov 30, 2024 - NCAA

TCU Horned Frogs
20 :  13
Cincinnati Bearcats

Nov 2, 2024 - NCAA

TCU Horned Frogs
34 :  37
Baylor Bears

Oct 19, 2024 - NCAA

TCU Horned Frogs
13 :  7
Utah Utes

Sep 28, 2024 - NCAA

TCU Horned Frogs
38 :  27
Kansas Jayhawks

Sep 21, 2024 - NCAA

TCU Horned Frogs
42 :  66
SMU Mustangs

SMU Mustangs against TCU Horned Frogs : Head to Head (H2H)

Sep 21, 2024 - NCAA

TCU Horned Frogs
42 :  66
SMU Mustangs

SMU Mustangs - TCU Horned Frogs Key Points

  1. TCU averages 45.0 points per game this season
  2. TCU allows an average of 17.5 points per game this season
  3. SMU averages 38.3 points per game this season
  4. SMU allows an average of 22.7 points per game this season
Up to $400+ to bet on SMU Mustangs - TCU Horned Frogs! 

Limited Offer. Currently at DraftKings

Our SMU Mustangs vs TCU Horned Frogs Prediction

TCU may have only played two games this season, but has won by at least three touchdowns in each game. Their offense has been electric this season, averaging 45.0 points per game, and while there might be some concern around their defense, having allowed 21 points to Abilene Christian, their offense more than makes up for this by being able to score points consistently. 

SMU, on the other hand, only has one loss this season, that being to Baylor in double overtime. The Mustangs were leading for most of the game, including with about six minutes left, but could not hang on back in Week 2. The Mustangs responded with an 18-point win against Missouri State in Week 3; however, this game against TCU will be a much tougher test.

The Mustangs have had moments this season of looking like a great team, but having already had trouble closing out a game, our SMU Mustangs vs TCU Horned Frogs prediction is: TCU Horned Frogs ML.

Prediction:

 

TCU ML

-250
$400+ offered for betting!

Jackpot Pools

DK Jackpot Pools

DraftKings's long-running promo Jackpot Pools gives bettors a chance to win a whopping $10,000 which grows with every entry! 

To win, you'll need to answer all 15 questions correctly and the pool is yours! If there are multiple winners, the pool will be split. If no one wins, however, the jackpot rolls over to the next pool, increasing the winnings. You can enter up to 10 times each pool to give yourself an even greater chance of winning. Once the event has completed, you can collect your winnings within 24 hours so keep an eye on the pool! Don't miss out on your chance to win big and make your picks today!

Get started today!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

SMU Mustangs vs TCU Horned Frogs Picks
Up to $400+ to bet on SMU Mustangs - TCU Horned Frogs! 

Limited Offer. Currently at DraftKings