South Florida Bulls vs Old Dominion Monarchs Prediction & Picks - NCAA Division I, FBS, Playoffs

USA - NCAA Division I, FBS, Playoffs

South Florida Bulls
12/17/25 17:00
Old Dominion Monarchs

Prediction:

 

Old Dominion ML

+140
$250 offered for betting!

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 by Travis Pulver | in Football Picks

The Old Dominion Monarchs (Sun Belt) will face off against the South Florida Bulls (American Athletic) in the StaffDNA Cure Bowl on Wednesday, December 17, at Camping World Stadium in Orlando, FL. Kickoff for this game is scheduled for 5 p.m. EST with coverage provided by ESPN.

After finishing 9-3 in the regular season, the Monarchs will try to match their best season record as an FBS team with a win over South Florida (10-3, 2016). The plan will likely be to do just what they did during the regular season—run, run, and run some more. Old Dominion had a top ten run game during the regular season with 236.9 ypg. Along with 223.8 ypg via the passing attack, they had the No. 15 offense in the country (total yards). They weren’t too shabby on defense, too, holding opponents to 331.4 ypg (total) and less than 20 points per game. As for South Florida, they became the darlings of the media after recording upsets over two ranked teams to start the season before Miami brought them back down to earth in Week 3. Like the Monarchs, they went on to finish their regular season with a 9-3 record. However, they had a more balanced and productive offense, No. 2 in total offense with 501.7 ypg and 43 ppg (No. 2 scoring).

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South Florida Bulls vs Old Dominion Monarchs Form

Table

Teams Pts P W L
14 Old Dominion Monarchs
1 1 1 0
119 South Florida Bulls
0 1 0 1

South Florida Bulls and Old Dominion Monarchs Latest Matches

South Florida Bulls
South Florida Bulls Latest matches
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 29, 2025 - NCAA

South Florida Bulls
52 :  3
Rice Owls

Nov 22, 2025 - NCAA

UAB Blazers
18 :  48
South Florida Bulls

Nov 15, 2025 - NCAA

Navy Midshipmen
41 :  38
South Florida Bulls

Nov 6, 2025 - NCAA

South Florida Bulls
55 :  23
UTSA Roadrunners

Oct 25, 2025 - NCAA

Memphis Tigers
34 :  31
South Florida Bulls

Oct 18, 2025 - NCAA

South Florida Bulls
48 :  13
Florida Atlantic Owls
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

South Florida Bulls
52 :  3
Rice Owls

Nov 6, 2025 - NCAA

South Florida Bulls
55 :  23
UTSA Roadrunners

Oct 18, 2025 - NCAA

South Florida Bulls
48 :  13
Florida Atlantic Owls

Oct 3, 2025 - NCAA

South Florida Bulls
54 :  26
Charlotte 49ers

Sep 20, 2025 - NCAA

South Florida Bulls
63 :  14
South Carolina State Bulldogs

Aug 28, 2025 - NCAA

South Florida Bulls
34 :  7
Boise State Broncos
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 22, 2025 - NCAA

UAB Blazers
18 :  48
South Florida Bulls

Nov 15, 2025 - NCAA

Navy Midshipmen
41 :  38
South Florida Bulls

Oct 25, 2025 - NCAA

Memphis Tigers
34 :  31
South Florida Bulls

Oct 10, 2025 - NCAA

North Texas Mean Green
36 :  63
South Florida Bulls

Sep 13, 2025 - NCAA

Miami Hurricanes
49 :  12
South Florida Bulls

Sep 6, 2025 - NCAA

Florida Gators
16 :  18
South Florida Bulls
Old Dominion Monarchs
Old Dominion Monarchs Latest matches
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 29, 2025 - NCAA

Old Dominion Monarchs
27 :  10
Georgia State Panthers

Nov 22, 2025 - NCAA

Georgia Southern Eagles
10 :  45
Old Dominion Monarchs

Nov 13, 2025 - NCAA

Old Dominion Monarchs
33 :  0
Troy Trojans

Nov 1, 2025 - NCAA

Louisiana-Monroe Warhawks
6 :  31
Old Dominion Monarchs

Oct 25, 2025 - NCAA

Old Dominion Monarchs
24 :  21
Appalachian State Mountaineers

Oct 18, 2025 - NCAA

James Madison Dukes
63 :  27
Old Dominion Monarchs
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Old Dominion Monarchs
27 :  10
Georgia State Panthers

Nov 13, 2025 - NCAA

Old Dominion Monarchs
33 :  0
Troy Trojans

Oct 25, 2025 - NCAA

Old Dominion Monarchs
24 :  21
Appalachian State Mountaineers

Oct 4, 2025 - NCAA

Old Dominion Monarchs
47 :  7
Coastal Carolina Chanticleers

Sep 27, 2025 - NCAA

Old Dominion Monarchs
21 :  7
Liberty Flames

Sep 6, 2025 - NCAA

Old Dominion Monarchs
54 :  6
North Carolina Central Eagles
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 22, 2025 - NCAA

Georgia Southern Eagles
10 :  45
Old Dominion Monarchs

Nov 1, 2025 - NCAA

Louisiana-Monroe Warhawks
6 :  31
Old Dominion Monarchs

Oct 18, 2025 - NCAA

James Madison Dukes
63 :  27
Old Dominion Monarchs

Oct 11, 2025 - NCAA

Marshall Herd
48 :  24
Old Dominion Monarchs

Sep 13, 2025 - NCAA

Virginia Tech Hokies
26 :  45
Old Dominion Monarchs

Aug 30, 2025 - NCAA

Indiana Hoosiers
27 :  14
Old Dominion Monarchs

South Florida Bulls - Old Dominion Monarchs Key Points

  1. This will be the first time Old Dominion and South Florida have faced off in a football game.
  2. While they had identical win-loss records, Old Dominion was 7-5 ATS and South Florida was 8-3-1.
  3. The OVER was 4-8 for Old Dominion and 7-5 for South Florida.
  4. Betting Public: 93% of moneyline tickets and 81% of the handle are on South Florida.
Up to $250 to bet on South Florida Bulls - Old Dominion Monarchs! 

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Our South Florida Bulls vs Old Dominion Monarchs Prediction

To complicate matters, we have to factor in two things for this game—neither team will have it’s starting quarterback available and USF has lost its head coach and many offensive assistants to Auburn. I’ve got more faith that Old Dominion’s Quinn Henicle (redshirt freshman) will be able to step up over South Florida’s Gaston Moore. Henicle led the Monarch’s to a 40-32 win over Arkansas State last season, running for 200+ yards in the process. Moore is a senior who has never started a game and his longest pass this season went for 13 yards.

Old Dominion has a better chance of overcoming the loss of its QB1 than South Florida. That gives Monarch’s ML a lot of value.

Our StaffDNA Cure Bowl Pick: Old Dominion ML

Prediction:

 

Old Dominion ML

+140
$250 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

South Florida Bulls vs Old Dominion Monarchs Picks