Missouri Tigers vs South Carolina Gamecocks Prediction & Picks - NCAA

USA - NCAA

Missouri Tigers
9/20/25 19:00
South Carolina Gamecocks

Prediction:

 

Missouri Tigers -9.5 Alternate Spread

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 by Matt Lowrimore | in NCAA Picks

The Saturday Week 4 slate in college football will feature a ton of exciting games, including an SEC matchup between the South Carolina Gamecocks and the 23rd-ranked Missouri Tigers. Let’s take a look at the match statistics and predictions for this game between the Gamecocks and Tigers.

South Carolina enters this game with a record of 2-1 and 0-1 in the SEC. The Gamecocks most recently lost to the Vanderbilt Commodores in Week 3 by a score of 31-7. South Carolina’s offense had a total of 328 yards, while its defense allowed 323 yards. Backup quarterback Luke Doty came in for injured quarterback LaNorris Sellors and threw for 148 yards and one interception, while running back Rahsul Faison led the team in rushing with 74 yards and one touchdown.

As for Missouri, they enter this game with a record of 3-0, and this will be their first game in the SEC this season. The Tigers most recently beat the Louisiana Ragin’ Cajuns in Week 3 by a score of 52-10. Missouri’s offense had a total of 606 yards, while its defense allowed 121 yards. Quarterback Beau Pribula threw for 174 yards, two touchdowns, and one interception, while running back Ahmad Hardy led the team in rushing with 250 yards and three touchdowns.

Missouri Tigers vs South Carolina Gamecocks Form

Table

Missouri Tigers and South Carolina Gamecocks Latest Matches

Missouri Tigers
Missouri Tigers Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 13, 2025 - NCAA

Missouri Tigers
52 :  10
Louisiana Ragin Cajuns

Sep 6, 2025 - NCAA

Missouri Tigers
42 :  31
Kansas Jayhawks

Aug 28, 2025 - NCAA

Missouri Tigers
61 :  6
Central Arkansas Bears

Oct 5, 2024 - NCAA

Texas AM Aggies
41 :  10
Missouri Tigers

Sep 21, 2024 - NCAA

Missouri Tigers
30 :  27
Vanderbilt Commodores

Sep 14, 2024 - NCAA

Missouri Tigers
27 :  21
Boston College Eagles
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 13, 2025 - NCAA

Missouri Tigers
52 :  10
Louisiana Ragin Cajuns

Sep 6, 2025 - NCAA

Missouri Tigers
42 :  31
Kansas Jayhawks

Aug 28, 2025 - NCAA

Missouri Tigers
61 :  6
Central Arkansas Bears

Sep 21, 2024 - NCAA

Missouri Tigers
30 :  27
Vanderbilt Commodores

Sep 14, 2024 - NCAA

Missouri Tigers
27 :  21
Boston College Eagles

Aug 29, 2024 - NCAA

Missouri Tigers
51 :  0
Murray State Racers
L
Victories

0/1 (0%)

Defeats

1/1 (100%)

Oct 5, 2024 - NCAA

Texas AM Aggies
41 :  10
Missouri Tigers
South Carolina Gamecocks
South Carolina Gamecocks Latest matches
L W W W L
Victories

3/5 (60%)

Defeats

2/5 (40%)

Sep 13, 2025 - NCAA

South Carolina Gamecocks
7 :  31
Vanderbilt Commodores

Sep 6, 2025 - NCAA

South Carolina Gamecocks
38 :  10
South Carolina State Bulldogs

Aug 31, 2025 - NCAA

South Carolina Gamecocks
24 :  11
Virginia Tech Hokies

Oct 19, 2024 - NCAA

Oklahoma Sooners
9 :  35
South Carolina Gamecocks

Sep 14, 2024 - NCAA

South Carolina Gamecocks
33 :  36
LSU Tigers
L W W L
Victories

2/4 (50%)

Defeats

2/4 (50%)

Sep 13, 2025 - NCAA

South Carolina Gamecocks
7 :  31
Vanderbilt Commodores

Sep 6, 2025 - NCAA

South Carolina Gamecocks
38 :  10
South Carolina State Bulldogs

Aug 31, 2025 - NCAA

South Carolina Gamecocks
24 :  11
Virginia Tech Hokies

Sep 14, 2024 - NCAA

South Carolina Gamecocks
33 :  36
LSU Tigers
W
Victories

1/1 (100%)

Defeats

0/1 (0%)

Oct 19, 2024 - NCAA

Oklahoma Sooners
9 :  35
South Carolina Gamecocks

Missouri Tigers - South Carolina Gamecocks Key Points

  1. Missouri is 3-0 ATS this season
  2. Missouri is averaging 51.7 points per game this season
  3. Missouri is allowing 15.7 points per game this season
  4. South Carolina’s LaNorris Sellors is questionable for this game

Our Missouri Tigers vs South Carolina Gamecocks Prediction

While Missouri has mostly played lower-level competition this season, they have still been one of the most impressive teams in the country. More specifically, their offense is averaging 51.7 points per game. Their defense has also allowed just 15.7 points per game, with the one blip against Kansas, where they allowed 31 points.

Further, the Tigers’ rushing offense has been lethal, averaging 302.3 points per game, while they are also averaging 284.7 passing yards per game. The biggest question mark in this game is the status of South Carolina quarterback LaNorris Sellors. Right now, he is status is uncertain, but even if he does play, Missouri is too balanced a team to let him beat them. For that reason, our South Carolina Gamecocks vs Missouri Tigers prediction is: Missouri Tigers -9.5 Alternate Spread.

Prediction:

 

Missouri Tigers -9.5 Alternate Spread

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Missouri Tigers vs South Carolina Gamecocks Picks